Fibroblast adhesion results in the induction of a matrix remodeling gene expression program.

[1]  Yunliang Chen,et al.  Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. , 2007, Matrix biology : journal of the International Society for Matrix Biology.

[2]  Yunliang Chen,et al.  FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. , 2007, Molecular biology of the cell.

[3]  Yunliang Chen,et al.  CCN2 is necessary for the function of mouse embryonic fibroblasts. , 2007, Experimental cell research.

[4]  Andrew Leask,et al.  All in the CCN family: essential matricellular signaling modulators emerge from the bunker , 2006, Journal of Cell Science.

[5]  C. Gladson,et al.  New concepts regarding focal adhesion kinase promotion of cell migration and proliferation , 2006, Journal of cellular biochemistry.

[6]  R. D. du Bois,et al.  Constitutive ALK5-Independent c-Jun N-Terminal Kinase Activation Contributes to Endothelin-1 Overexpression in Pulmonary Fibrosis: Evidence of an Autocrine Endothelin Loop Operating through the Endothelin A and B Receptors , 2006, Molecular and Cellular Biology.

[7]  A. Leask Scar wars: is TGFβ the phantom menace in scleroderma? , 2006, Arthritis research & therapy.

[8]  Yunliang Chen,et al.  CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-β1 in Embryonic Fibroblasts* , 2006, Journal of Biological Chemistry.

[9]  Yunliang Chen,et al.  Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease. , 2005, The American journal of pathology.

[10]  M. Jinnin,et al.  Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts. , 2005, The Journal of investigative dermatology.

[11]  M. Clozel,et al.  Role of endothelin in fibrosis and anti‐fibrotic potential of bosentan , 2005, Annals of medicine.

[12]  Giulio Gabbiani,et al.  Perspective Article: Tissue repair, contraction, and the myofibroblast , 2005, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[13]  Yunliang Chen,et al.  CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. , 2004, Molecular biology of the cell.

[14]  M. Schaller FAK and paxillin , 2004, The Journal of cell biology.

[15]  Yunliang Chen,et al.  Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. , 2004, Molecular biology of the cell.

[16]  R. D. du Bois,et al.  Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK* , 2004, Journal of Biological Chemistry.

[17]  Andrew Leask,et al.  TGF‐β signaling and the fibrotic response , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  Giulio Gabbiani,et al.  Mechanisms of force generation and transmission by myofibroblasts. , 2003, Current opinion in biotechnology.

[19]  Y. Yoshioka,et al.  Focal adhesion kinase is required for endothelin‐induced cell cycle progression of cultured astrocytes , 2003, Glia.

[20]  J. Parsons,et al.  Focal adhesion kinase: the first ten years , 2003, Journal of Cell Science.

[21]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[22]  J. Strait,et al.  Endothelin-induced cardiac myocyte hypertrophy: role for focal adhesion kinase. , 2000, American journal of physiology. Heart and circulatory physiology.

[23]  R. Clark Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin. , 1990, The Journal of investigative dermatology.

[24]  E. Ruoslahti,et al.  Fibronectin and its integrin receptors in cancer. , 1999, Advances in cancer research.