Thorax perfusion CT in non-small cell lung cancer

OBJECTIVES We aimed to determine the perfusion differences according to the histological type, stage, volume and prognoses in the non-small cell carcinoma by thorax perfusion CT. MATERIALS AND METHODS Twenty-four non-small cell carcinoma patients were included in the study. Thorax perfusion CT was done to evaluate the tumors in terms of perfusion parameters: blood flow (BF) and time to peak (TTP) values. RESULTS The total blood flow of the tumor in squamous cell carcinoma was significantly higher than adenocarcinoma (p=0.031). There was no statistical difference between the perfusion parameters and other parameters. CONCLUSIONS Perfusion CT may help us in evaluating non-small cell carcinomas.

[1]  M Buyse,et al.  Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis. , 1997, The American journal of pathology.

[2]  S. Diederich,et al.  Solitary pulmonary nodule: detection and management , 2006, Cancer imaging : the official publication of the International Cancer Imaging Society.

[3]  K. Miles,et al.  Perfusion CT: a worthwhile enhancement? , 2003, The British journal of radiology.

[4]  M. Prokop,et al.  New imaging techniques in the treatment guidelines for lung cancer , 2002, European Respiratory Journal.

[5]  M. Brundage,et al.  Prognostic factors in non-small cell lung cancer: a decade of progress. , 2002, Chest.

[6]  Fabian Kiessling,et al.  Perfusion CT in patients with advanced bronchial carcinomas: a novel chance for characterization and treatment monitoring? , 2004, European Radiology.

[7]  Ernst Klotz,et al.  Lung cancer perfusion at multi-detector row CT: reproducibility of whole tumor quantitative measurements. , 2006, Radiology.

[8]  C. Calli,et al.  Perfusion and diffusion MR imaging in enhancing malignant cerebral tumors. , 2006, European journal of radiology.

[9]  E. Raaymakers,et al.  Brain metastases and non-small cell lung cancer. Prognostic factors and correlation with survival after irradiation. , 2001, Lung cancer.

[10]  E. Fishman,et al.  Application of CT in the investigation of angiogenesis in oncology. , 2000, Academic radiology.

[11]  M. Chung,et al.  Solid or partly solid solitary pulmonary nodules: their characterization using contrast wash-in and morphologic features at helical CT. , 2007, Chest.

[12]  A. Alavi,et al.  Recent advances in pulmonary imaging. , 1999, Chest.

[13]  A. Giatromanolaki,et al.  Assessment of vascular maturation in non-small cell lung cancer using a novel basement membrane component, LH39: correlation with p53 and angiogenic factor expression. , 1999, Cancer research.