Infectious complications of hepatic artery catheterization procedures in patients with cancer.

A total of 353 hepatic artery catheterization procedures were carried out in 211 patients with cancer over a 1-year period (January-December 1988). The procedures included 49 embolizations in 32 patients, 123 chemoembolizations in 73 patients, and 181 chemoinfusions in 106 patients. The overall infection rate was 3.4%. Infectious complications occurred in 3.1% of patients undergoing hepatic artery embolization alone, 1.9% of patients undergoing hepatic artery chemoinfusion, and 4.1% of patients undergoing hepatic artery embolization followed by chemoinfusion. Four patients had infectious complications that included four episodes each of cholangitis, liver abscess, and septicemia. One patient developed a subphrenic abscess in addition to a liver abscess. Enteric gram-negative bacilli (aerobic and anaerobic) were isolated from all four patients. None of the patients had received prophylactic antibiotics. All patients responded to antimicrobial therapy and percutaneous drainage of abscesses.

[1]  M. Sternlicht,et al.  Effect of antimicrobial protection on tolerance to hepatic chemoembolization with a fibrous collagen carrier. , 1989, Radiology.

[2]  D. Allison,et al.  Complications of embolization: analysis of 410 procedures. , 1988, Radiology.

[3]  Hiroshi Hasegawa,et al.  Combined peripheral and central chemoembolization of liver tumors. Experience with lipiodol‐doxorubicin and gelatin sponge (L‐TAE) , 1988, Cancer.

[4]  Z. Arlin,et al.  Hepatic abscess following hepatic arterial infusion chemotherapy with an implantable pump. , 1986, Cancer investigation.

[5]  D. Allison,et al.  THERAPEUTIC EMBOLISATION OF THE HEPATIC ARTERY: A REVIEW OF 75 PROCEDURES , 1985, The Lancet.

[6]  J. Niederhuber.  Surgical Aspects of Intrahepatic Artery Therapy , 1985 .

[7]  M. Clouse,et al.  Prolonged and continuous percutaneous intra‐arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary , 1979, Cancer.

[8]  I. Ariel,et al.  Treatment of asymptomatic metastatic cancer to the liver from primary colon and rectal cancer by the intraarterial administration of chemotherapy and radioactive isotopes , 1982, Journal of surgical oncology.

[9]  C. Charnsangavej,et al.  Therapeutic Ivalon embolization of hepatic tumors. , 1982, AJR. American journal of roentgenology.

[10]  S. Wallace,et al.  Hepatic artery infusion chemotherapy: gastroduodenal complications. , 1981, AJR. American journal of roentgenology.

[11]  S. Wallace,et al.  THE PALLIATIVE ROLE OF HEPATIC ARTERIAL INFUSION AND ARTERIAL OCCLUSION IN COLORECTAL CARCINOMA METASTATIC TO THE LIVER , 1981, The Lancet.

[12]  V. Vaitkevicius,et al.  The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: Ten‐year results of 124 patients in a prospective protocol , 1981, Cancer.

[13]  T. Hall,et al.  Transfemoral hepatic artery infusion for metastatic carcinoma , 1981, Journal of surgical oncology.

[14]  L. Rodrigo,et al.  Liver abscess complicating embolization of focal nodular hyperplasia. , 1979, AJR. American journal of roentgenology.

[15]  C. D'Orsi,et al.  Clostridial sepsis following hepatic arterial infusion chemotherapy. , 1979, The American journal of medicine.

[16]  J. Doppman,et al.  Proximal versus peripheral hepatic artery embolization experimental study in monkeys. , 1978, Radiology.

[17]  S. Shirazi,et al.  Iatrogenic liver abscesses. A complication of hepatic artery ligation for tumor. , 1978, Archives of surgery.

[18]  J. Rösch,et al.  Complications of indwelling chemotherapy catheters , 1975, Cancer.

[19]  R. Lucas,et al.  Hepatic Artery Occlusion Following Hepatic Artery Catheterization , 1971, Annals of surgery.