Efficient Delivery of Therapeutic miRNA Nanocapsules for Tumor Suppression

miRNA nanocapsules are synthesized with enhanced stability for miRNA delivery with high transduction efficiency, offering a novel class of miRNA vectors for cancer therapy.

[1]  Yang Li,et al.  Cationic microRNA-delivering nanovectors with bifunctional peptides for efficient treatment of PANC-1 xenograft model. , 2013, Biomaterials.

[2]  Stefano Piccolo,et al.  MicroRNA control of signal transduction , 2010, Nature Reviews Molecular Cell Biology.

[3]  M. Wood,et al.  Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA , 2012, Molecular Therapy - Nucleic Acids.

[4]  C. Kang,et al.  Aspirin‐/TMZ‐coloaded Microspheres Exert Synergistic Antiglioma Efficacy via Inhibition of β‐catenin Transactivation , 2013, CNS neuroscience & therapeutics.

[5]  S. Oh,et al.  A highly effective and long-lasting inhibition of miRNAs with PNA-based antisense oligonucleotides , 2009, Molecules and cells.

[6]  Colette McDonagh,et al.  Inhibition of Neuroblastoma Tumor Growth by Targeted Delivery of MicroRNA-34a Using Anti-Disialoganglioside GD2 Coated Nanoparticles , 2012, PloS one.

[7]  D. M. Pereira,et al.  Delivering the promise of miRNA cancer therapeutics. , 2013, Drug discovery today.

[8]  C. Burge,et al.  Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets , 2005, Cell.

[9]  R. David,et al.  Innovative Strategy for MicroRNA Delivery in Human Mesenchymal Stem Cells via Magnetic Nanoparticles , 2013, International journal of molecular sciences.

[10]  Mei Mei,et al.  Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status , 2010, Laboratory Investigation.

[11]  John J. Rossi,et al.  The promises and pitfalls of RNA-interference-based therapeutics , 2009, Nature.

[12]  R. Hartmann,et al.  MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. , 2011, Cancer research.

[13]  B. Cullen,et al.  Sequence requirements for micro RNA processing and function in human cells. , 2003, RNA.

[14]  K. Kosik,et al.  MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. , 2005, Cancer research.

[15]  L. Lyon,et al.  Multifunctional nanogels for siRNA delivery. , 2012, Accounts of chemical research.

[16]  B. Jiang,et al.  MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression , 2011, PloS one.

[17]  N. Sarvetnick,et al.  Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[18]  D. Bartel MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[19]  W. Filipowicz,et al.  Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? , 2008, Nature Reviews Genetics.

[20]  Ming Yan,et al.  Protein nanocapsule weaved with enzymatically degradable polymeric network. , 2009, Nano letters.

[21]  Zhen Gu,et al.  A novel intracellular protein delivery platform based on single-protein nanocapsules. , 2010, Nature nanotechnology.

[22]  Kathryn A. O’Donnell,et al.  Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model , 2009, Cell.

[23]  Ming-Yu Yang,et al.  Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas. , 2014, Cancer letters.

[24]  J. Kurreck RNA Interference: From Basic Research to Therapeutic Applications , 2009, Angewandte Chemie.

[25]  J. Sheng,et al.  Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma. , 2014, Biomaterials.

[26]  Y. Negishi,et al.  Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia , 2014, Scientific Reports.

[27]  F. Slack,et al.  Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[28]  W. H. Blackburn,et al.  Peptide-functionalized nanogels for targeted siRNA delivery. , 2009, Bioconjugate chemistry.

[29]  P. Gunaratne,et al.  A gold nanoparticle platform for the delivery of functional microRNAs into cancer cells. , 2013, Biomaterials.

[30]  D. Bartel MicroRNAs: Target Recognition and Regulatory Functions , 2009, Cell.

[31]  B. Liu,et al.  Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[32]  T. Karlsen,et al.  Liposome delivery of microRNA-145 to mesenchymal stem cells leads to immunological off-target effects mediated by RIG-I. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

[33]  Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial. , 2013, ACS nano.

[34]  H. Horvitz,et al.  MicroRNA expression profiles classify human cancers , 2005, Nature.

[35]  J. Datta,et al.  Lipid-based nanoparticle delivery of Pre-miR-107 inhibits the tumorigenicity of head and neck squamous cell carcinoma. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[36]  Mark A. Kay,et al.  Progress and problems with the use of viral vectors for gene therapy , 2003, Nature Reviews Genetics.

[37]  W. F. Anderson Assessment of adenoviral vector safety and toxicity: Report of the National Institutes of Health Recombinant DNA Advisory Committee , 2002 .