Movement preparation in self-initiated versus externally triggered movements: an event-related fMRI-study

In the present study, we used fMRI to investigate whether event-related preparatory processes of self-initiated and externally triggered movements differ. Twenty subjects were examined with 1000 T2*-weighted images in two consecutive sessions. During the first session subjects performed self-initiated abductions of the right index finger. For the second session subjects were instructed to perform the movements in response to visual cues. Number and timing of movements were matched between conditions. For statistical inference on multisubject level, random effects analyses were performed. Significantly enhanced activity during self-initiated compared to externally triggered movements was found within the left SMA, the left pre- and sensorimotor cortex, the right putamen, the left anterior cingulate gyrus, and the left inferior parietal lobe. The significantly increased activity during self-initiated in comparison to externally triggered movements might represent differential demands of the two conditions on the neuronal motor net during movement preparation, reflecting utilization of precise knowledge when to move in self-initiated movements. Our results emphasize a possible role of the primary motor cortex for movement preparation as observed in electrophysiological studies, but do not support a specific involvement of the dorsolateral prefrontal cortex as suggested by former block design studies.

[1]  Albert Gjedde,et al.  Origin of Human Motor Readiness Field Linked to Left Middle Frontal Gyrus by MEG and PET , 1998, NeuroImage.

[2]  Ivan Rektor,et al.  Scalp-recorded Bereitschaftspotential is the result of the activity of cortical and subcortical generators – a hypothesis , 2002, Clinical Neurophysiology.

[3]  D. Stuss,et al.  Principles of frontal lobe function , 2002 .

[4]  H. Lüders,et al.  Movement-related potentials recorded from supplementary motor area and primary motor area. Role of supplementary motor area in voluntary movements. , 1992, Brain : a journal of neurology.

[5]  C. Marsden,et al.  Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects. , 1995, Brain : a journal of neurology.

[6]  Karl J. Friston,et al.  How Many Subjects Constitute a Study? , 1999, NeuroImage.

[7]  Karl J. Friston,et al.  Statistical parametric maps in functional imaging: A general linear approach , 1994 .

[8]  Ewald Moser,et al.  The preparation and readiness for voluntary movement: a high-field event-related fMRI study of the Bereitschafts-BOLD response , 2003, NeuroImage.

[9]  B Conrad,et al.  Time-resolved fMRI of activation patterns in M1 and SMA during complex voluntary movement. , 2001, Journal of neurophysiology.

[10]  J. Assad,et al.  Putaminal activity for simple reactions or self-timed movements. , 2003, Journal of neurophysiology.

[11]  G. Lindinger,et al.  Supplementary Motor Area Activation Preceding Voluntary Movement Is Detectable with a Whole-Scalp Magnetoencephalography System , 2000, NeuroImage.

[12]  M. Hallett,et al.  Comparison of Auditory, Somatosensory, and Visually Instructed and Internally Generated Finger Movements: A PET Study , 2001, NeuroImage.

[13]  Michael Erb,et al.  Sequential activation of supplementary motor area and primary motor cortex during self-paced finger movement in human evaluated by functional MRI , 1997, Neuroscience Letters.

[14]  M Hallett,et al.  Self-paced versus metronome-paced finger movements. A positron emission tomography study. , 1997, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[15]  M. Honda,et al.  Both primary motor cortex and supplementary motor area play an important role in complex finger movement. , 1993, Brain : a journal of neurology.

[16]  L. Deecke,et al.  The Preparation and Execution of Self-Initiated and Externally-Triggered Movement: A Study of Event-Related fMRI , 2002, NeuroImage.

[17]  G. Thickbroom,et al.  Cerebral potentials accompanying visually triggered finger movement in man. , 1985, Electroencephalography and clinical neurophysiology.

[18]  David Badre,et al.  Temporal Sensitivity of Event-Related fMRI , 2002, NeuroImage.

[19]  H. Diener,et al.  Impaired movement-related potentials in acute frontal traumatic brain injury , 2004, Clinical Neurophysiology.

[20]  B. Feige,et al.  The Role of Higher-Order Motor Areas in Voluntary Movement as Revealed by High-Resolution EEG and fMRI , 1999, NeuroImage.

[21]  H. Kornhuber,et al.  Hirnpotentialänderungen bei Willkürbewegungen und passiven Bewegungen des Menschen: Bereitschaftspotential und reafferente Potentiale , 1965, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[22]  R. Passingham,et al.  Self-initiated versus externally triggered movements. II. The effect of movement predictability on regional cerebral blood flow. , 2000, Brain : a journal of neurology.

[23]  Karl J. Friston,et al.  A Study of Analysis Parameters That Influence the Sensitivity of Event-Related fMRI Analyses , 2000, NeuroImage.

[24]  M. D’Esposito,et al.  The Organization of Working Memory Function in Lateral Prefrontal Cortex: Evidence from Event-Related Functional MRI , 2002 .

[25]  W G Tatton,et al.  Contributions of the mesial frontal cortex to the premovement potentials associated with intermittent hand movements in humans , 1996, Human brain mapping.

[26]  E. Rolls,et al.  Neuronal activity of the supplementary motor area (SMA) during internally and externally triggered wrist movements , 1988, Neuroscience Letters.

[27]  L. Deecke,et al.  Neuroimage of Voluntary Movement: Topography of the Bereitschaftspotential, a 64-Channel DC Current Source Density Study , 1999, NeuroImage.

[28]  J. Tanji,et al.  Neuronal activities in the primate motor fields of the agranular frontal cortex preceding visually triggered and self-paced movement , 2004, Experimental Brain Research.

[29]  R. Turner,et al.  Detecting Latency Differences in Event-Related BOLD Responses: Application to Words versus Nonwords and Initial versus Repeated Face Presentations , 2002, NeuroImage.

[30]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[31]  O Josephs,et al.  Event-related functional magnetic resonance imaging: modelling, inference and optimization. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[32]  M. Hallett,et al.  Mesial motor areas in self-initiated versus externally triggered movements examined with fMRI: effect of movement type and rate. , 1999, Journal of neurophysiology.

[33]  I Rektor,et al.  Intracerebral recording of movement related readiness potentials: an exploration in epileptic patients. , 1994, Electroencephalography and clinical neurophysiology.

[34]  W. Schultz,et al.  Neuronal activity preceding self-initiated or externally timed arm movements in area 6 of monkey cortex , 2004, Experimental Brain Research.

[35]  A. Gordon,et al.  Functional magnetic resonance imaging of motor, sensory, and posterior parietal cortical areas during performance of sequential typing movements , 1998, Experimental Brain Research.