Effortful information processing in a spontaneous spatial situation by rats with medial prefrontal lesions

Previous research has suggested that the rat prefrontal cortex might play a role in spatial information processing and in divided attention. More recent work showed that the effect of prefrontal lesions is more important when the task involves response selection in complex situations. The first aim of the present study was to test the effect of lesions of the prelimbic area of the rat prefrontal cortex in spatial exploration, a situation involving the processing of spatial and non-spatial information, but requiring no response selection. The second aim was to manipulate the degree of cognitive effort required by the task. The latter effect was tested by manipulating the number of items to explore. Rats explored either a simple (3 objects) or a complex (6 objects) situation. We reasoned that acquiring spatial information so as to react adequately to spatial or non spatial changes involved more effortful processing in the complex situation than in the simpler one. The results suggest that the medial prefrontal cortex is not crucially involved in effortful processing when the task requires no response selection.

[1]  Bryan Kolb,et al.  Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat , 1982, Neuroscience Letters.

[2]  Bryan Kolb,et al.  Functions of the frontal cortex of the rat: A comparative review , 1984, Brain Research Reviews.

[3]  D. Olton,et al.  Object discrimination by rats: The role of frontal and hippocampal systems in retention and reversal , 1980, Physiology & Behavior.

[4]  H. Rouanet,et al.  COMPARISON BETWEEN TREATMENTS IN A REPEATED‐MEASUREMENT DESIGN: ANOVA AND MULTIVARIATE METHODS , 1970 .

[5]  C. Thinus-Blanc,et al.  A Study of Spatial Parameters Encoded During Exploration in Hamsters , 1987 .

[6]  G. N. Brito,et al.  Septohippocampal system and the prelimbic sector of frontal cortex: A neuropsychological battery analysis in the rat , 1990, Behavioural Brain Research.

[7]  B. Kolb,et al.  The Cerebral cortex of the rat , 1990 .

[8]  B. Poucet.  Object exploration, habituation, and response to a spatial change in rats following septal or medial frontal cortical damage. , 1989, Behavioral neuroscience.

[9]  C. Thinus-Blanc,et al.  A study of exploratory behavior as an index of spatial knowledge in hamsters , 1986 .

[10]  T. Robbins,et al.  Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man , 1991, Neuropsychologia.

[11]  T. Robbins,et al.  Response-related deficits following unilateral lesions of the medial agranular cortex of the rat. , 1991, Behavioral neuroscience.

[12]  N. V. Poll,et al.  Delayed spatial response alternation: Effects of delay-interval duration and lesions of the medial prefrontal cortex on response accuracy of male and female Wistar rats , 1985, Behavioural Brain Research.

[13]  J. Fuster.  Prefrontal Cortex , 2018 .

[14]  B. Poucet,et al.  A further characterization of the spatial problem-solving deficit induced by lesions of the medial frontal cortex in the rat , 1990, Behavioural Brain Research.

[15]  E Save,et al.  Object exploration and reactions to spatial and nonspatial changes in hooded rats following damage to parietal cortex or hippocampal formation. , 1992, Behavioral neuroscience.

[16]  R. Sutherland,et al.  A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats. , 1983, Behavioral neuroscience.

[17]  M. J. Renner.  Neglected aspects of exploratory and investigatory behavior , 1990, Psychobiology.

[18]  Thom Herrmann,et al.  Septum and medial frontal cortex contribution to spatial problem-solving , 1990, Behavioural Brain Research.

[19]  D. Olton,et al.  Neuroanatomical bases of spatial memory , 1980, Brain Research.

[20]  D. Crowne,et al.  Parietal and frontal eye field neglect in the rat , 1986, Behavioural Brain Research.

[21]  R. Church,et al.  Attention and the frontal cortex as examined by simultaneous temporal processing , 1988, Neuropsychologia.

[22]  C. Legg.  Spatial contrast and flicker sensitivity following medial thalamic or visual cortex lesions in hooded rats , 1986, Behavioural Brain Research.

[23]  J. Muir,et al.  The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task. , 1996, Cerebral cortex.

[24]  J. M. Warren,et al.  THE FRONTAL GRANULAR CORTEX AND BEHAVIOR , 1964 .

[25]  Bruno Poucet,et al.  Working memory, response selection, and effortful processing in rats with medial prefrontal lesions , 1994 .

[26]  B Poucet,et al.  Medial prefrontal lesions in the rat and spatial navigation: evidence for impaired planning. , 1995, Behavioral neuroscience.