Transfectable and Transplantable Postmitotic Human Neurons: A Potential “Platform” for Gene Therapy of Nervous System Diseases
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J. Trojanowski | V. Lee | S. Kesari | S. Kleppner | R. Hartley | M. Miyazono | N. Fraser
[1] P. Nowell,et al. Long‐term integration and neuronal differentiation of human embryonal carcinoma cells (NT era‐2) transplanted into the caudoputamen of nude mice , 1996, The Journal of comparative neurology.
[2] J. Trojanowski,et al. Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[3] Nobuhiro Suzuki,et al. Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation (*) , 1996, The Journal of Biological Chemistry.
[4] J. Trojanowski,et al. Human fetal hippocampal development: II. The neuronal cytoskeleton , 1996, The Journal of comparative neurology.
[5] V. Lee,et al. Site-specific Dephosphorylation of Tau Protein at Ser/Thr in Response to Microtubule Depolymerization in Cultured Human Neurons Involves Protein Phosphatase 2A (*) , 1996, The Journal of Biological Chemistry.
[6] C. Svendsen,et al. Neurones from stem cells? , 1995, Trends in Neurosciences.
[7] J. Trojanowski,et al. Therapy of experimental human brain tumors using a neuroattenuated herpes simplex virus mutant. , 1995, Laboratory investigation; a journal of technical methods and pathology.
[8] V. Lee,et al. Proliferation, cell death, and neuronal differentiation in transplanted human embryonal carcinoma (NTera2) cells depend on the graft site in nude and severe combined immunodeficient mice. , 1995, Laboratory investigation; a journal of technical methods and pathology.
[9] J. Trojanowski,et al. Transplanted human neurons derived from a teratocarcinoma cell line (NTera‐2) mature, integrate, and survive for over 1 year in the nude mouse brain , 1995, The Journal of comparative neurology.
[10] B. Wolf,et al. Muscarinic Regulation of Alzheimer's Disease Amyloid Precursor Protein Secretion and Amyloid β-Protein Production in Human Neuronal NT2N Cells (*) , 1995, The Journal of Biological Chemistry.
[11] J. Trojanowski,et al. Human neurons that constitutively secrete Aβ do not induce Alzheimer's disease pathology following transplantation and long-term survival in the rodent brain , 1995, Brain Research.
[12] F. Gage,et al. Isolation, characterization, and use of stem cells from the CNS. , 1995, Annual review of neuroscience.
[13] G. B. Pierce,et al. Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers. , 1994, Laboratory investigation; a journal of technical methods and pathology.
[14] F. Gage,et al. Gene therapy for neurologic disease. , 1993, Archives of neurology.
[15] J. Trojanowski,et al. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[16] J. Trojanowski,et al. Expression of neuronal and glial polypeptides during histogenesis of the human cerebellar cortex including observations on the dentate nucleus , 1993, The Journal of comparative neurology.
[17] Virginia M. Y. Lee,et al. NTera 2 Cells: A human cell line which displays characteristics expected of a human committed neuronal progenitor cell , 1993, Journal of neuroscience research.
[18] J. Trojanowski,et al. Neurons Derived from a Human Teratocarcinoma Cell Line Establish Molecular and Structural Polarity Following Transplantation into the Rodent Brain , 1993, Experimental Neurology.
[19] J. Trojanowski,et al. Tau Proteins Are Abnormally Expressed in Olfactory Epithelium of Alzheimer Patients and Developmentally Regulated in Human Fetal Spinal Cord , 1993, Experimental Neurology.
[20] V. Lee,et al. Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[21] Scott T. Grafton,et al. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. , 1992, The New England journal of medicine.
[22] V M Lee,et al. Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[23] J. Trojanowski,et al. Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. , 1992, Laboratory investigation; a journal of technical methods and pathology.
[24] J. Trojanowski,et al. Molecular milestones that signal axonal maturation and the commitment of human spinal cord precursor cells to the neuronal or glial phenotype in development , 1991, The Journal of comparative neurology.
[25] J Q Trojanowski,et al. Human olfactory epithelium in normal aging, alzheimer's disease, and other neurodegenerative disorders , 1991, The Journal of comparative neurology.
[26] J. Trojanowski,et al. Early fetal acquisition of the chromaffin and neuronal immunophenotype by human adrenal medullary cells. An immunohistological study using monoclonal antibodies to chromogranin A, synaptophysin, tyrosine hydroxylase, and neuronal cytoskeletal proteins , 1990, Experimental Neurology.
[27] J. Craig,et al. Differentiation and maturation of embryonal carcinoma-derived neurons in cell culture , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[28] J. Trojanowski,et al. Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[29] P. Andrews,et al. Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[30] P. Andrews. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. , 1984, Developmental biology.
[31] N C Dracopoli,et al. Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. , 1984, Laboratory investigation; a journal of technical methods and pathology.
[32] M. Darmon,et al. Control by the extracellular environment of differentiation pathways in 1003 embryonal carcinoma cells: study at the level of specific intermediate filaments. , 1982, The EMBO journal.
[33] M. McBurney,et al. Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells , 1982, The Journal of cell biology.