Genomic landscape of non-small-cell lung cancer in smokers and never-smokers

Whole-genome and transcriptome sequencing studies were performed on 17 tumour and adjacent normal tissue samples from smokers, former light smokers and never-smokers diagnosed with non-small-cell lung cancer. This sequencing-based study revealed a markedly distinct genomic landscape in smokers and never-smokers. Smokers had an average mutation frequency 10-fold higher than never-smokers and a significantly …