Susceptibility to a Dexamethasone Intraocular Implant with and Without Concomitant Oral Steroid Intake: A Case Report

Introduction: This case report addresses the possible and controversial influence of a concomitant oral steroid intake on the efficacy of a dexamethasone intravitreal implant (Ozurdex) in treating macular edema (ME), mostly when related to inflammatory ocular diseases. Case Presentation: A 34-year-old Caucasian male with Behcet's disease (BD) presented with central retinal vein occlusion (CRVO), first in one eye and then in the other. The eye affected first showed a favorable course. The eye next affected, instead, developed chronic ME poorly responsive to systemic and local treatments. In this eye, two Ozurdex implants were finally performed with a 6-month interval. During the uneventful follow up to the first injection, an episode of central serous chorioretinopathy occurred in the fellow non-implanted eye. This caused the end of the long-lasting oral steroidal regimen, due to the well known negative effect of steroids on

[1]  P. Mitchell,et al.  Effect of the duration of macular edema on clinical outcomes in retinal vein occlusion treated with dexamethasone intravitreal implant. , 2012, Ophthalmology.

[2]  F. Bandello,et al.  Dexamethasone Intravitreal Implant In Patients With Refractory Diabetic Macular Edema , 2012 .

[3]  M. Blumenkranz,et al.  Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results. , 2011, Ophthalmology.

[4]  S. Siddique,et al.  Road to remission: a comprehensive review of therapy in uveitis , 2011, Expert opinion on investigational drugs.

[5]  C. Lowder,et al.  Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. , 2011, Archives of ophthalmology.

[6]  Jane S. Myung,et al.  Treatment of noninfectious posterior uveitis with dexamethasone intravitreal implant , 2010, Clinical ophthalmology.

[7]  M. Blumenkranz,et al.  Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. , 2010, Ophthalmology.

[8]  George A. Williams,et al.  Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema. , 2010, Archives of ophthalmology.

[9]  George A. Williams,et al.  Dexamethasone posterior-segment drug delivery system in the treatment of macular edema resulting from uveitis or Irvine-Gass syndrome. , 2009, American journal of ophthalmology.