Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity
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Manuel Vlach | Nicolas Quesnot | Hélène Dubois-Pot-Schneider | Catherine Ribault | Yann Verres | Kilian Petitjean | Claudine Rauch | Fabrice Morel | Marie-Anne Robin | Anne Corlu | Pascal Loyer | P. Loyer | Nicolas Quesnot | C. Rauch | F. Morel | M. Robin | A. Corlu | Hélène Dubois-Pot-Schneider | C. Ribault | Kilian Petitjean | Manuel Vlach | Yann Verres
[1] S. Langouet,et al. Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.
[2] W. Suter. Predictive value of in vitro safety studies. , 2006, Current opinion in chemical biology.
[3] J. Pascussi,et al. Zearalenone activates pregnane X receptor, constitutive androstane receptor and aryl hydrocarbon receptor and corresponding phase I target genes mRNA in primary cultures of human hepatocytes. , 2011, Environmental toxicology and pharmacology.
[4] A. Guillouzo,et al. Optimization of the HepaRG cell model for drug metabolism and toxicity studies. , 2012, Toxicology in vitro : an international journal published in association with BIBRA.
[5] R. Rose,et al. Endosulfan‐α Induces CYP2B6 and CYP3A4 by Activating the Pregnane X Receptor , 2010, Toxicology and applied pharmacology.
[6] B. Drénou,et al. Transdifferentiation of hepatocyte‐like cells from the human hepatoma HepaRG cell line through bipotent progenitor , 2007, Hepatology.
[7] C. Guguen-Guillouzo,et al. Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye. , 2011, Toxicology and applied pharmacology.
[8] Olivier Fardel,et al. Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells. , 2013, Toxicology in vitro : an international journal published in association with BIBRA.
[9] S. Wolfe,et al. Timing of new black box warnings and withdrawals for prescription medications. , 2002, JAMA.
[10] D. Lagadic-Gossmann,et al. Liver Protection from Apoptosis Requires Both Blockage of Initiator Caspase Activities and Inhibition of ASK1/JNK Pathway via Glutathione S-Transferase Regulation* , 2002, The Journal of Biological Chemistry.
[11] P. Staňková,et al. The toxic effect of thioacetamide on rat liver in vitro. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.
[12] André Guillouzo,et al. EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS , 2006, Drug Metabolism and Disposition.
[13] Frank Stahl,et al. Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[14] Tsuneo Hashizume,et al. Advantages of human hepatocyte-derived transformants expressing a series of human cytochrome p450 isoforms for genotoxicity examination. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.
[15] K. Boudjema,et al. Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression. , 2009, European journal of cancer.
[16] D. Zalko,et al. Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines. , 2010, Toxicology letters.
[17] D. Glaise,et al. Inflammatory cytokines promote the retrodifferentiation of tumor‐derived hepatocyte‐like cells to progenitor cells , 2014, Hepatology.
[18] A. Guillouzo,et al. Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells , 2012, Drug Metabolism and Disposition.
[19] M. Filipič,et al. A cell-based biosensor system HepG2CDKN1A-DsRed for rapid and simple detection of genotoxic agents. , 2014, Biosensors & bioelectronics.
[20] L. Corcos,et al. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. , 1993, Molecular pharmacology.
[21] Christian Trepo,et al. Infection of a human hepatoma cell line by hepatitis B virus , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[22] L. Corcos,et al. Up-regulation of glutathione S-transferases alpha by interleukin 4 in human hepatocytes in primary culture. , 1995, Biochemical and biophysical research communications.
[23] M. Vinken,et al. Characterization of hepatocyte-based in vitro systems for reliable toxicity testing , 2018, Archives of Toxicology.
[24] J. Castell,et al. Re‐expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells , 1998 .
[25] A. Guillouzo,et al. Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. , 2010, Toxicology and applied pharmacology.
[26] Mitsuo Oshimura,et al. Dual-Color Fluorescence Imaging to Monitor CYP3A4 and CYP3A7 Expression in Human Hepatic Carcinoma HepG2 and HepaRG Cells , 2014, PloS one.
[27] A. Puisieux,et al. Cell cycle gene regulation in reversibly differentiated new human hepatoma cell lines. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[28] Marlon J. A. Jetten,et al. Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes. , 2013, Toxicology in vitro : an international journal published in association with BIBRA.
[29] M. Lamberti,et al. Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model. , 2016, Toxicology letters.
[30] P. Loyer,et al. Efficient transfection of Xenobiotic Responsive Element-biosensor plasmid using diether lipid and phosphatidylcholine liposomes in differentiated HepaRG cells. , 2017, International journal of pharmaceutics.
[31] G. Hatch,et al. Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells. , 2016, Biochimica et biophysica acta.
[32] R. Hanzlik,et al. Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes. , 2012, Chemical research in toxicology.
[33] Valérie Fessard,et al. Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies , 2008, Drug Metabolism and Disposition.
[34] P. Loyer,et al. Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes , 2018, Archives of Toxicology.
[35] P. Loyer,et al. Evaluation of genotoxicity using automated detection of γH2AX in metabolically competent HepaRG cells. , 2015, Mutagenesis.
[36] Tommy B Andersson,et al. Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies , 2008, Drug Metabolism and Disposition.
[37] André Guillouzo,et al. Evolving concepts in liver tissue modeling and implications for in vitro toxicology , 2008, Expert opinion on drug metabolism & toxicology.