Long term vagal stimulation in patients with advanced heart failure First experience in man

Experimentally, vagal stimulation (VS) is protective in chronic heart failure (HF). In man, VS is used in refractory epilepsy but has never been used in cardiovascular diseases. Increased sympathetic and reduced vagal activity predict increased mortality in HF.

[1]  Masaru Sugimachi,et al.  Vagal Nerve Stimulation Markedly Improves Long-Term Survival After Chronic Heart Failure in Rats , 2003, Circulation.

[2]  Mustafa M. Husain,et al.  Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial , 2005, Biological Psychiatry.

[3]  P. Schwartz,et al.  Vagal activity and ventricular fibrillation , 1994 .

[4]  A. Cohn.  ON THE DIFFERENCES IN THE EFFECTS OF STIMULATION OF THE TWO VAGUS NERVES ON RATE AND CONDUCTION OF THE DOG'S HEART , 1912, The Journal of experimental medicine.

[5]  P. Schwartz,et al.  Exercise-Induced Increase in Baroreflex Sensitivity Predicts Improved Prognosis After Myocardial Infarction , 2002, Circulation.

[6]  B. Uthman,et al.  Effectiveness of vagus nerve stimulation in epilepsy patients , 2004, Neurology.

[7]  H. Sabbah,et al.  509 Therapy with Vagus nerve electrical stimulation combined with beta‐blockade improves left ventricular systolic function in dogs with heart failure beyond that seen with beta‐blockade alone , 2007 .

[8]  M. Dunlap,et al.  Ganglionic mechanisms contribute to diminished vagal control in heart failure. , 1999, Circulation.

[9]  H. L. Stone,et al.  The effects of daily exercise on susceptibility to sudden cardiac death. , 1984, Circulation.

[10]  P. Schwartz,et al.  Pharmacologic modulation of the autonomic nervous system in the prevention of sudden cardiac death. A study with propranolol, methacholine and oxotremorine in conscious dogs with a healed myocardial infarction. , 1993, Journal of the American College of Cardiology.

[11]  M. Dunlap,et al.  Prevention of diminished parasympathetic control of the heart in experimental heart failure. , 2004, American journal of physiology. Heart and circulatory physiology.

[12]  G D Pinna,et al.  Arterial baroreflex modulation of heart rate in chronic heart failure: clinical and hemodynamic correlates and prognostic implications. , 1997, Circulation.

[13]  M. N. Levy,et al.  Vagal Control of the Heart: Experimental Basis and Clinical Implications , 1994 .

[14]  W. Abraham,et al.  Continuous Autonomic Assessment in Patients With Symptomatic Heart Failure: Prognostic Value of Heart Rate Variability Measured by an Implanted Cardiac Resynchronization Device , 2004, Circulation.

[15]  Kevin J. Tracey,et al.  The inflammatory reflex , 2002, Nature.

[16]  Steven C Schachter,et al.  Vagus nerve stimulation therapy summary: Five years after FDA approval , 2002, Neurology.

[17]  P. Schwartz,et al.  Baroreflex sensitivity predicts long-term cardiovascular mortality after myocardial infarction even in patients with preserved left ventricular function. , 2007, Journal of the American College of Cardiology.

[18]  Alan Frazer,et al.  VNS Therapy in Treatment-Resistant Depression: Clinical Evidence and Putative Neurobiological Mechanisms , 2006, Neuropsychopharmacology.

[19]  M. Shuchman.  Approving the vagus-nerve stimulator for depression. , 2007, The New England journal of medicine.

[20]  M T La Rovere,et al.  [Baroreflex sensitivity]. , 2001, Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology.

[21]  J. Bigger,et al.  Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction , 1998, The Lancet.

[22]  C. Jf,et al.  [Diabetic autonomic neuropathy]. , 1989, Atencion primaria.

[23]  E. Ben-Menachem,et al.  Vagus Nerve Stimulation, Side Effects, and Long-Term Safety , 2001, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[24]  M Pagani,et al.  Heart rate variability and autonomic diabetic neuropathy. , 2000, Diabetes, nutrition & metabolism.

[25]  P. Schwartz,et al.  Autonomic mechanisms and sudden death. New insights from analysis of baroreceptor reflexes in conscious dogs with and without a myocardial infarction. , 1988, Circulation.

[26]  J. Jalife,et al.  Cardiac Electrophysiology: From Cell to Bedside , 1990 .

[27]  S. S. Hull,et al.  Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction. , 1991, Circulation research.