Evaluation of yield of currently available diagnostics by sample type to optimize detection of respiratory pathogens in patients with a community-acquired pneumonia

For the detection of respiratory pathogens, the sampling strategy may influence the diagnostic yield. Ideally, samples from the lower respiratory tract are collected, but they are difficult to obtain.

[1]  M. Kochen,et al.  Antibiotics for community-acquired pneumonia in adult outpatients. , 2014, The Cochrane database of systematic reviews.

[2]  D. Murdoch,et al.  Association between pneumococcal load and disease severity in adults with pneumonia. , 2012, Journal of medical microbiology.

[3]  S. Madhi,et al.  Use of a rapid test of pneumococcal colonization density to diagnose pneumococcal pneumonia. , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  A. Torres,et al.  Community-acquired pneumonia in outpatients: aetiology and outcomes , 2012, European Respiratory Journal.

[5]  E. Walsh,et al.  Yield of Sputum for Viral Detection by Reverse Transcriptase PCR in Adults Hospitalized with Respiratory Illness , 2011, Journal of Clinical Microbiology.

[6]  E. Walsh,et al.  Respiratory Syncytial Virus Infection in Adults , 2011, Seminars in respiratory and critical care medicine.

[7]  B. Kullberg,et al.  Q fever in the Netherlands from 2007 to 2010. , 2010, The Netherlands journal of medicine.

[8]  Y. Shemer-Avni,et al.  Respiratory Viruses in Adults With Community-Acquired Pneumonia , 2010, Chest.

[9]  W. Melchers,et al.  Interlaboratory Evaluation of Different Extraction and Real-Time PCR Methods for Detection of Coxiella burnetii DNA in Serum , 2010, Journal of Clinical Microbiology.

[10]  V. Ortiz de la Tabla,et al.  Comparison of Combined Nose-Throat Swabs with Nasopharyngeal Aspirates for Detection of Pandemic Influenza A/H1N1 2009 Virus by Real-Time Reverse Transcriptase PCR , 2010, Journal of Clinical Microbiology.

[11]  J. Hedlund,et al.  Etiology of Community-Acquired Pneumonia: Increased Microbiological Yield with New Diagnostic Methods , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  J. Blomberg,et al.  Is quantitative PCR for the pneumolysin (ply) gene useful for detection of pneumococcal lower respiratory tract infection? , 2009, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[13]  J. Rossen,et al.  Human Bocavirus and KI/WU Polyomaviruses in Pediatric Intensive Care Patients , 2009, Emerging infectious diseases.

[14]  R. Silbergleit,et al.  Blood cultures for community-acquired pneumonia: are they worthy of two quality measures? A systematic review. , 2009, Journal of hospital medicine.

[15]  J. Fox,et al.  Viral Infection in Adults Hospitalized With Community-Acquired Pneumonia , 2008, Chest.

[16]  G. Waterer,et al.  The etiology of community-acquired pneumonia in Australia: why penicillin plus doxycycline or a macrolide is the most appropriate therapy. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[17]  J. Hedlund,et al.  Quantitative detection of Streptococcus pneumoniae from sputum samples with real-time quantitative polymerase chain reaction for etiologic diagnosis of community-acquired pneumonia. , 2008, Diagnostic microbiology and infectious disease.

[18]  H. Leufkens,et al.  Eur J Clin Pharmacol (2008) 64:405–410 DOI 10.1007/s00228-007-0407-0 PHARMACOEPIDEMIOLOGY AND PRESCRIPTION , 2022 .

[19]  C. Vandenbroucke-Grauls,et al.  Utility of Real-Time PCR for Diagnosis of Legionnaires’ Disease in Routine Clinical Practice , 2007, Journal of Clinical Microbiology.

[20]  B. Diederen,et al.  Are Oropharyngeal Swabs Suitable as Samples for Legionella-Specific PCR Testing? , 2007, Journal of Clinical Microbiology.

[21]  D. Murdoch,et al.  Incidence and characteristics of viral community-acquired pneumonia in adults , 2007, Thorax.

[22]  J. Rossen,et al.  Increased Detection of Respiratory Syncytial Virus, Influenza Viruses, Parainfluenza Viruses, and Adenoviruses with Real-Time PCR in Samples from Patients with Respiratory Symptoms , 2007, Journal of Clinical Microbiology.

[23]  P. Palange,et al.  From the authors , 2007, European Respiratory Journal.

[24]  A. Ortqvist,et al.  Quantitative detection of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in lower respiratory tract samples by real-time PCR. , 2006, Diagnostic microbiology and infectious disease.

[25]  B. Wever,et al.  Development of an internally controlled real-time PCR assay for detection of Chlamydophila psittaci in the LightCycler 2.0 system. , 2006, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[26]  J. Rossen,et al.  Diagnostic value of real-time polymerase chain reaction to detect viruses in young children admitted to the paediatric intensive care unit with lower respiratory tract infection , 2006, Critical care.

[27]  A. Bartelds,et al.  A Case-Control Study of Acute Respiratory Tract Infection in General Practice Patients in The Netherlands , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[28]  E. Claas,et al.  Improved Diagnosis of the Etiology of Community-Acquired Pneumonia with Real-Time Polymerase Chain Reaction , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[29]  T. Pumarola,et al.  The Role of Viruses in the Aetiology of Community-Acquired Pneumonia in Adults , 2005, Antiviral therapy.

[30]  C. Font,et al.  Assessment of the usefulness of sputum culture for diagnosis of community-acquired pneumonia using the PORT predictive scoring system. , 2004, Archives of internal medicine.

[31]  T. File Streptococcus pneumoniae and community-acquired pneumonia: A cause for concern , 2004, The American Journal of Medicine Supplements.

[32]  R. de Groot,et al.  Streptococcus pneumoniae colonisation: the key to pneumococcal disease. , 2004, The Lancet. Infectious diseases.

[33]  韩旭东,et al.  Viral pneumonia , 2004 .

[34]  T. File Community-acquired pneumonia , 2003, The Lancet.

[35]  D. Murdoch,et al.  Evaluation of a PCR Assay for Detection of Streptococcus pneumoniae in Respiratory and Nonrespiratory Samples from Adults with Community-Acquired Pneumonia , 2003, Journal of Clinical Microbiology.

[36]  M. Niederman,et al.  Applying sputum as a diagnostic tool in pneumonia: limited yield, minimal impact on treatment decisions. , 2002, Chest.

[37]  L. Burman,et al.  Limited Value of Routine Microbiological Diagnostics in Patients Hospitalized for Community-acquired Pneumonia , 2002, Scandinavian journal of infectious diseases.

[38]  D. Nadal,et al.  Quantitative Detection of Streptococcus pneumoniae in Nasopharyngeal Secretions by Real-Time PCR , 2001, Journal of Clinical Microbiology.

[39]  J. Dorca,et al.  Prospective study of the usefulness of sputum Gram stain in the initial approach to community-acquired pneumonia requiring hospitalization. , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[40]  Sheldon P Stone,et al.  Community-acquired pneumonia , 1998, The Lancet.

[41]  H. Zanen,et al.  Q fever in the Netherlands. , 1958, Tropical and geographical medicine.

[42]  Mina Kim,et al.  Comparison of sputum and nasopharyngeal swab specimens for molecular diagnosis of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. , 2012, Annals of laboratory medicine.

[43]  S. Osajima [VIRAL PNEUMONIA]. , 1963, Naika. Internal medicine.