Treatment of low-grade oligodendroglial tumors without radiotherapy

The authors prospectively treated 18 consecutive patients with low-grade oligodendroglial tumors without postoperative radiotherapy. The treatment strategy was as follows: follow-up after total resection and chemotherapy after subtotal resection or biopsy. All patients were alive and 17 patients (94%) were progression-free after a median follow-up of 4.7 years. The results suggested that radiotherapy could be postponed until clinical progression in the treatment of low-grade oligodendroglial tumors.

[1]  G. Krol,et al.  Low-grade oligodendroglioma responds to chemotherapy , 1996, Neurology.

[2]  B. Scheithauer,et al.  Prospective randomized trial of low- versus high-dose radiation therapy in adults with supratentorial low-grade glioma: initial report of a North Central Cancer Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group study. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[3]  Philippe Cornu,et al.  Randomized trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: European Organization for Research and Treatment of Cancer Study 22845 with the Medical Research Council study BRO4: an interim analysis. , 2002, International journal of radiation oncology, biology, physics.

[4]  A. Fortuna,et al.  Cerebral oligodendroglioma: prognostic factors and life history. , 1994, Neurosurgery.

[5]  L. Deangelis,et al.  Long-term outcome of low-grade oligodendroglioma and mixed glioma , 2000, Neurology.

[6]  R. Hatlevoll,et al.  Statistical analysis of clinicopathological features, radiotherapy, and survival in 170 cases of oligodendroglioma. , 1987, Journal of neurosurgery.

[7]  C. Lui,et al.  Treatment outcomes and prognostic factors of patients with supratentorial low-grade oligodendroglioma. , 2002, International journal of radiation oncology, biology, physics.

[8]  A. Karim,et al.  A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) Study 22844. , 1996, International journal of radiation oncology, biology, physics.

[9]  B. Scheithauer,et al.  Oligodendrogliomas: the Mayo Clinic experience. , 1992, Journal of neurosurgery.

[10]  D. Louis,et al.  Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. , 1998, Journal of the National Cancer Institute.