Integrins in cancer: biological implications and therapeutic opportunities
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[1] Robert A. Beckman,et al. Phase I Evaluation of a Fully Human Anti–αv Integrin Monoclonal Antibody (CNTO 95) in Patients with Advanced Solid Tumors , 2007, Clinical Cancer Research.
[2] J. Munger. The integrin αvβ6 binds and activates latent TGFβ1 : A mechanism for regulating pulmonary inflammation and fibrosis , 1999 .
[3] O. G. Ramprasad,et al. Lipopeptide with a RGDK tetrapeptide sequence can selectively target genes to proangiogenic alpha5beta1 integrin receptor and mouse tumor vasculature. , 2008, Journal of medicinal chemistry.
[4] K. Yoshimatsu,et al. α6β1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells , 2003, Oncogene.
[5] F. Aoudjit,et al. Matrix Attachment Regulates FAS-Induced Apoptosis in Endothelial Cells , 2001, The Journal of cell biology.
[6] C. Tacchetti,et al. Integrin-induced Epidermal Growth Factor (EGF) Receptor Activation Requires c-Src and p130Cas and Leads to Phosphorylation of Specific EGF Receptor Tyrosines* , 2002, The Journal of Biological Chemistry.
[7] M. Zöller. Tetraspanins: push and pull in suppressing and promoting metastasis , 2009, Nature Reviews Cancer.
[8] D. Cheresh,et al. Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. , 1991, The Journal of clinical investigation.
[9] F. Giancotti,et al. Integrin β4 signaling promotes tumor angiogenesis , 2004 .
[10] M. Kitajima,et al. The Relationship Between Bone Metastasis from Human Breast Cancer and Integrin αvβ3 Expression , 2005 .
[11] T. Byzova,et al. Prostate cancer specific integrin αvβ3 modulates bone metastatic growth and tissue remodeling , 2007, Oncogene.
[12] Jonathan R. Lindner,et al. Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to &agr;v-Integrins , 2003, Circulation.
[13] B. Escudier,et al. A Phase I Pharmacokinetic and Biological Correlative Study of IMP321, a Novel MHC Class II Agonist, in Patients with Advanced Renal Cell Carcinoma , 2009, Clinical Cancer Research.
[14] S. Santoro,et al. Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[15] A. Burgess,et al. Laminin-10 Mediates Basal and EGF-Stimulated Motility of Human Colon Carcinoma Cells via α3β1 and α6β4 Integrins , 2001 .
[16] Dai Fukumura,et al. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. , 2007, Microvascular research.
[17] Marie-Liesse Asselin-Labat,et al. Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation , 2007, Nature Cell Biology.
[18] J. Tímár,et al. Multiple Roles for Platelet GPIIb/IIIa and αvβ3 Integrins in Tumor Growth, Angiogenesis, and Metastasis , 2002 .
[19] X. Bu,et al. EFFECT OF THE ANGIOGENESIS INHIBITOR CILENGITIDE (EMD 121974) ON GLIOBLASTOMA GROWTH IN NUDE MICE , 2006, Neurosurgery.
[20] Sejeong Shin,et al. A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling. , 2006, Cancer research.
[21] Chih-Hsin Tang,et al. Osteoblasts‐derived TGF‐β1 enhance motility and integrin upregulation through Akt, ERK, and NF‐κB‐dependent pathway in human breast cancer cells , 2008 .
[22] W. Oyen,et al. Tumor Targeting with Radiolabeled v 3 Integrin Binding Peptides in a Nude Mouse Model , 2002 .
[23] J. Lindquist,et al. Cooperation between VEGF and beta3 integrin during cardiac vascular development. , 2007, Blood.
[24] David C. Smith,et al. Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: scientific rationale and study design. , 2006, Clinical genitourinary cancer.
[25] A. Fangberget,et al. Integrin receptor imaging of breast cancer: a proof-of-concept study to evaluate 99mTc-NC100692. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[26] William P Schiemann,et al. β3 Integrin and Src facilitate transforming growth factor-β mediated induction of epithelial-mesenchymal transition in mammary epithelial cells , 2006, Breast Cancer Research.
[27] Fan Wang,et al. Integrin αvβ3-Targeted Radioimmunotherapy of Glioblastoma Multiforme , 2008, Clinical Cancer Research.
[28] David A. Cheresh,et al. Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis , 2003, The Journal of cell biology.
[29] R. Soldi,et al. Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor‐2 , 1999, The EMBO journal.
[30] D. Stupack,et al. A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature. , 2006, The Journal of clinical investigation.
[31] S. Caruthers,et al. Minute dosages of ανβ3‐targeted fumagillin nanoparticles impair Vx‐2 tumor angiogenesis and development in rabbits , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[32] J. Qin,et al. VEGF-integrin interplay controls tumor growth and vascularization. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[33] L. Trusolino,et al. β4 integrin activates a Shp2–Src signaling pathway that sustains HGF-induced anchorage-independent growth , 2006, The Journal of cell biology.
[34] M. Berger,et al. Integrin beta3 overexpression suppresses tumor growth in a human model of gliomagenesis: implications for the role of beta3 overexpression in glioblastoma multiforme. , 2004, Cancer research.
[35] G. Thomas,et al. alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. , 2008, Cancer research.
[36] R. Timpl,et al. Conformation/activity studies of rationally designed potent anti-adhesive RGD peptides. , 1992, European journal of biochemistry.
[37] I. Jurisica,et al. Integrin α11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells , 2007, Proceedings of the National Academy of Sciences.
[38] Fadlo R Khuri,et al. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. , 2006, Cancer research.
[39] T. N. Campbell,et al. Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[40] F. Sarkar,et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. , 1995, The Journal of clinical investigation.
[41] Alessia Pica,et al. Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[42] S. Frisch,et al. Anoikis mechanisms. , 2001, Current opinion in cell biology.
[43] Zaverio M. Ruggeri,et al. Role of 3 Integrins in Melanoma Cell Adhesion to Activated Platelets under Flow (*) , 1996, The Journal of Biological Chemistry.
[44] J. Lindsey,et al. HGF and ligation of αvβ5 integrin induce a novel, cancer cell-specific gene expression required for cell scattering , 2004 .
[45] P. Houghton,et al. Potentiation of neuroblastoma metastasis by loss of caspase-8 , 2006, Nature.
[46] S. Hanks,et al. Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. , 2009, Cancer research.
[47] D. Cheresh,et al. Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin. , 1992, The Journal of clinical investigation.
[48] M. Chellaiah,et al. Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells. , 2006, Experimental cell research.
[49] Wenjie Bao,et al. Integrin αv-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen , 2004, The Journal of cell biology.
[50] R. Baron,et al. Tumor αvβ3 Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases , 2007 .
[51] M. Bouvet,et al. Integrin-mediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells. , 2007, Surgery.
[52] David A. Cheresh,et al. Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging , 1998, Nature Medicine.
[53] Yan Ning,et al. Down-regulation of integrin alpha2 surface expression by mutant epidermal growth factor receptor (EGFRvIII) induces aberrant cell spreading and focal adhesion formation. , 2005, Cancer research.
[54] N. Kaminski,et al. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. , 1999, Cell.
[55] W. Oyen,et al. αvβ3 Integrin‐targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide , 2007 .
[56] Luzhe Sun,et al. Control of Type II Transforming Growth Factor-β Receptor Expression by Integrin Ligation* , 1999, The Journal of Biological Chemistry.
[57] J Engel,et al. Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins. , 1994, The Journal of biological chemistry.
[58] M. Trikha,et al. CNTO 95, a fully human monoclonal antibody that inhibits αv integrins, has antitumor and antiangiogenic activity in vivo , 2004, International journal of cancer.
[59] Andrew J. Lindsay,et al. Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments , 2008, The Journal of cell biology.
[60] B. Saville,et al. Absence of Adverse Effects in Cynomolgus Macaques Treated with CNTO 95, a Fully Human Anti-αv Integrin Monoclonal Antibody, Despite Widespread Tissue Binding , 2005, Clinical Cancer Research.
[61] R. Klemke,et al. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. , 1997, The Journal of clinical investigation.
[62] D. Taverna,et al. Increased primary tumor growth in mice null for β3- or β3/β5-integrins or selectins , 2004 .
[63] D. Jonas,et al. CXCR4 Chemokine Receptor Mediates Prostate Tumor Cell Adhesion through α5 and β3 Integrins , 2006 .
[64] D. Shaw,et al. Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours , 2006, British Journal of Cancer.
[65] Horst Kessler,et al. N-methylated cyclic RGD peptides as highly active and selective αvβ3 integrin antagonists , 1999 .
[66] Wolfhard Semmler,et al. Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner. , 2007, Cancer research.
[67] L. Liotta,et al. Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells , 1990, The Journal of cell biology.
[68] S. Teitelbaum,et al. Unoccupied αvβ3 Integrin Regulates Osteoclast Apoptosis by Transmitting a Positive Death Signal , 2005 .
[69] Jan G. Hengstler,et al. ERBB2-Mediated Transcriptional Up-regulation of the α5β1 Integrin Fibronectin Receptor Promotes Tumor Cell Survival Under Adverse Conditions , 2006 .
[70] M. Bednarski,et al. Tumor Regression by Targeted Gene Delivery to the Neovasculature , 2002, Science.
[71] M. Wicha,et al. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. , 2009, Cancer research.
[72] Michele Pagano,et al. Role of the F-Box Protein Skp2 in Adhesion-Dependent Cell Cycle Progression , 2001, The Journal of cell biology.
[73] Milind Rajopadhye,et al. Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model. , 2002, Cancer research.
[74] A. Tolcher,et al. Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds α5β1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study , 2008, Clinical Cancer Research.
[75] R. Dubridge,et al. Volociximab, a chimeric integrin alpha5beta1 antibody, inhibits the growth of VX2 tumors in rabbits , 2008, Investigational New Drugs.
[76] Christopher D. Manning,et al. αv Integrin-Targeted Immunoconjugates Regress Established Human Tumors in Xenograft Models , 2007, Clinical Cancer Research.
[77] A. Mercurio,et al. The Met Receptor and α6β4 Integrin Can Function Independently to Promote Carcinoma Invasion* , 2004, Journal of Biological Chemistry.
[78] G. Christofori,et al. Increased tumor cell dissemination and cellular senescence in the absence of β1‐integrin function , 2007, The EMBO journal.
[79] T. MacDonald,et al. Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[80] J. Menéndez,et al. αVβ3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer , 2005, Oncogene.
[81] R. Assoian,et al. Growth control by intracellular tension and extracellular stiffness. , 2008, Trends in cell biology.
[82] W. Gerald,et al. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. , 2009, The Journal of clinical investigation.
[83] B. Garmy-Susini,et al. Integrin α4β1 Promotes Monocyte Trafficking and Angiogenesis in Tumors , 2006 .
[84] Milan Makale,et al. Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis , 2008, Proceedings of the National Academy of Sciences.
[85] J. Sosman,et al. A phase II, randomized, open-label study evaluating the antitumor activity of MEDI-522, a humanized monoclonal antibody directed against the human alpha v beta 3 (avb3) integrin, {+/-} dacarbazine (DTIC) in patients with metastatic melanoma (MM) , 2005 .
[86] D. Ribatti. The contribution of Harold F. Dvorak to the study of tumor angiogenesis and stroma generation mechanisms. , 2007, Endothelium : journal of endothelial cell research.
[87] F. Giancotti,et al. Elevated levels of the α 5 β 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells , 1990, Cell.
[88] G. Inghirami,et al. β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis , 2006, Cell.
[89] S. Lim,et al. Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motility , 2008, Oncogene.
[90] J. Massagué,et al. Cell adhesion protein receptors as targets for transforming growth factor-β action , 1987, Cell.
[91] L. Trusolino,et al. Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis. , 2005, Cancer research.
[92] E. Danen,et al. Emergence of α5β1 fibronectin‐ and αvβ3 vitronectin‐receptor expression in melanocytic tumour progression , 1994 .
[93] Hiroyuki Shimada,et al. Preferential Susceptibility of Brain Tumors to the Antiangiogenic Effects of an &agr;v Integrin Antagonist , 2001, Neurosurgery.
[94] Masahiro Inoue,et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. , 2009, Cancer cell.
[95] A. Sonnenberg,et al. Integrin αvβ3 Controls Activity and Oncogenic Potential of Primed c-Src , 2007 .
[96] F. Ross,et al. Superactivation of integrin alphavbeta3 by low antagonist concentrations. , 2001, Journal of cell science.
[97] D. McDonald,et al. Cellular abnormalities of blood vessels as targets in cancer. , 2005, Current opinion in genetics & development.
[98] D. Aebersold,et al. Correlation between the tumoral expression of β3-integrin and outcome in cervical cancer patients who had undergone radiotherapy , 2004, British Journal of Cancer.
[99] J W Smith,et al. Integrin activation controls metastasis in human breast cancer. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[100] Massimo Cristofanilli,et al. β4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer , 2005, Modern Pathology.
[101] W. Cai,et al. In vitro and In vivo Characterization of 64Cu-Labeled AbegrinTM, a Humanized Monoclonal Antibody against Integrin αvβ3 , 2006 .
[102] Z. Hua,et al. Enhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature , 2008, Molecular Cancer Therapeutics.
[103] K. Yamada,et al. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors , 1996, The Journal of cell biology.
[104] K. Legate,et al. ILK, PINCH and parvin: the tIPP of integrin signalling , 2006, Nature Reviews Molecular Cell Biology.
[105] S. Dixon,et al. Effects of Vitaxin®, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro , 2007, Journal of cellular biochemistry.
[106] G. Krissansen,et al. Antisense integrin αV and β3 gene therapy suppresses subcutaneously implanted hepatocellular carcinomas , 2007 .
[107] Peter S. Conti,et al. MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide , 2004, European Journal of Nuclear Medicine and Molecular Imaging.
[108] P. del Vecchio,et al. Fibronectin fragments released from phorbol ester-stimulated pulmonary artery endothelial cell monolayers promote neutrophil chemotaxis. , 1991, Immunology.
[109] R. Stupp,et al. Phase I/IIa trial of cilengitide (EMD121974) and temozolomide with concomitant radiotherapy, followed by temozolomide and cilengitide maintenance therapy in patients (pts) with newly diagnosed glioblastoma (GBM) , 2007 .
[110] John M L Ebos,et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. , 2009, Cancer cell.
[111] E. Ruoslahti,et al. Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor , 1985, Cell.
[112] A. Oberg,et al. Intravascularly administered RGD-displaying measles viruses bind to and infect neovessel endothelial cells in vivo. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.
[113] E. Ruoslahti,et al. αvβ3 integrin associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF , 1997 .
[114] E. Danen,et al. Integrin beta 3 cDNA transfection into a highly metastatic alpha v beta 3-negative human melanoma cell line inhibits invasion and experimental metastasis. , 1996, Biochemical and biophysical research communications.
[115] David A. Cheresh,et al. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins , 2001, The Journal of cell biology.
[116] M. Tomasson,et al. Platelet and osteoclast β3 integrins are critical for bone metastasis , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[117] Ryan Park,et al. MicroPET imaging of breast cancer alphav-integrin expression with 64Cu-labeled dimeric RGD peptides. , 2004, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.
[118] D. Griggs,et al. A small molecule antagonist of the αvβ3 integrin suppresses MDA-MB-435 skeletal metastasis , 2004, Clinical & Experimental Metastasis.
[119] D. Cheresh. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[120] T. Byzova,et al. The angiogenic response is dictated by β3 integrin on bone marrow–derived cells , 2008, The Journal of cell biology.
[121] Horst Kessler,et al. Noninvasive Visualization of the Activated αvβ3 Integrin in Cancer Patients by Positron Emission Tomography and [18F]Galacto-RGD , 2005, PLoS medicine.
[122] N. Fausto,et al. NF-κB Mediates αvβ3 Integrin-induced Endothelial Cell Survival , 1998, The Journal of cell biology.
[123] George E. Davis,et al. Affinity of integrins for damaged extracellular matrix: αvβ3 binds to denatured collagen type I through RGD sites , 1992 .
[124] J. Visvader,et al. The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. , 2008, Cancer research.
[125] K. Friedrichs,et al. High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival. , 1995, Cancer research.
[126] David A. Cheresh,et al. Definition of Two Angiogenic Pathways by Distinct αv Integrins , 1995, Science.
[127] L. Trusolino,et al. A Signaling Adapter Function for α6β4 Integrin in the Control of HGF-Dependent Invasive Growth , 2001, Cell.
[128] D. Elder,et al. Integrin Distribution in Malignant Melanoma : Association of the ß 3 Subunit with Tumor Progression 1 , 2006 .
[129] C. Miranti,et al. Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases , 2006, Oncogene.
[130] J. Burger,et al. CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells , 2005, Oncogene.
[131] J. Iredale,et al. The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via αv Integrin Ligation , 2008, Clinical Cancer Research.
[132] A. Pozzi,et al. Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. , 2009, Cancer research.
[133] R. Dubridge,et al. A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo , 2007, Journal of Translational Medicine.
[134] D. Griggs,et al. Anti-metastatic properties of RGD-peptidomimetic agents S137 and S247 , 2004, Clinical & Experimental Metastasis.
[135] J. Uhm,et al. Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[136] L. Hudson,et al. Activated Epidermal Growth Factor Receptor Induces Integrin α2 Internalization via Caveolae/Raft-dependent Endocytic Pathway* , 2007, Journal of Biological Chemistry.
[137] A. Skretting,et al. Integrin scintimammography using a dedicated breast imaging, solid‐state γ‐camera and 99mTc‐labelled NC100692 , 2008, Clinical physiology and functional imaging.
[138] B. Garmy-Susini,et al. Integrins in angiogenesis and lymphangiogenesis , 2008, Nature Reviews Cancer.
[139] A. Gorter,et al. Overexpression of the αvβ6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival , 2007 .
[140] Joe W Gray,et al. Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. , 2006, Cancer research.
[141] D. Cheresh,et al. Requirement of vascular integrin alpha v beta 3 for angiogenesis. , 1994, Science.
[142] G. Giannelli,et al. Targeting transforming growth factor (TGF)‐βRI inhibits activation of β1 integrin and blocks vascular invasion in hepatocellular carcinoma , 2009, Hepatology.
[143] W. Muller,et al. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. , 2004, Cancer cell.
[144] Christopher S. Chen,et al. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion , 2008, Journal of Cell Science.
[145] E. Wayner,et al. Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface , 1991, The Journal of cell biology.
[146] D. Schlaepfer,et al. Integrin-regulated FAK-Src signaling in normal and cancer cells. , 2006, Current opinion in cell biology.
[147] P. Oettgen,et al. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. , 2005, The Journal of clinical investigation.
[148] T. Mikkelsen,et al. Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[149] Jianhua Huang,et al. A Role for VEGF as a Negative Regulator of Pericyte Function and Vessel Maturation , 2008, Nature.
[150] A. Sonnenberg,et al. Integrins Uncouple Src-induced Morphological and Oncogenic Transformation* , 2008, Journal of Biological Chemistry.
[151] F. Mitjans,et al. Integrin αVβ3 Promotes M21 Melanoma Growth in Human Skin by Regulating Tumor Cell Survival , 1999 .
[152] N. Kohno,et al. Significance of Integrin α5 Gene Expression as a Prognostic Factor in Node-negative Non-Small Cell Lung Cancer , 2000 .
[153] J. Norman,et al. αvβ3 and α5β1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration , 2007, The Journal of cell biology.
[154] D. Hicklin,et al. Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in β3-Integrin–Deficient Mice , 2004, Cancer Research.
[155] Robin L. Anderson,et al. Tumor-specific expression of αvβ3 integrin promotes spontaneous metastasis of breast cancer to bone , 2006, Breast Cancer Research.
[156] Jens Eickhoff,et al. Phase I Trial of a Monoclonal Antibody Specific for αvβ3 Integrin (MEDI-522) in Patients with Advanced Malignancies, Including an Assessment of Effect on Tumor Perfusion , 2005, Clinical Cancer Research.
[157] D. Tarin,et al. Integrin αvβ3/c-src “Oncogenic Unit” Promotes Anchorage-independence and Tumor Progression , 2009, Nature Medicine.
[158] D. Cheresh,et al. Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. , 1990, The Journal of biological chemistry.
[159] F. Ross,et al. Superactivation of integrin (α)v(β)3 by low antagonist concentrations , 2001 .
[160] C. Giachelli,et al. Src Kinase Activity Is Required for Integrin αVβ3-Mediated Activation of Nuclear Factor-κB* , 2005, Journal of Biological Chemistry.
[161] F. McCabe,et al. CNTO 95, a fully human anti αv integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells , 2007, Clinical & Experimental Metastasis.
[162] T. Byzova,et al. Mechanisms of Integrin–Vascular Endothelial Growth Factor Receptor Cross-Activation in Angiogenesis , 2007, Circulation research.
[163] R. Timpl,et al. Arg‐Gly‐Asp constrained within cyclic pentapoptides Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1 , 1991, FEBS letters.
[164] R. Hwang,et al. Integrin α4β1–VCAM-1–mediated adhesion between endothelial and mural cells is required for blood vessel maturation , 2005 .
[165] A. Shilkaitis,et al. Molecular prognostic markers in intermediate‐thickness cutaneous malignant melanoma , 1999, Cancer.
[166] L. Ellis,et al. Inhibition of integrin α5β1 function with a small peptide (ATN‐161) plus continuous 5‐FU infusion reduces colorectal liver metastases and improves survival in mice , 2003, International journal of cancer.
[167] E. Ruoslahti,et al. Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain* , 2000, The Journal of Biological Chemistry.
[168] M. Conaway,et al. Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. , 2009, Cancer research.
[169] T. Mikkelsen,et al. Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[170] D. Taverna,et al. A Direct Test of Potential Roles for β3 and β5 Integrins in Growth and Metastasis of Murine Mammary Carcinomas , 2005 .
[171] W. Schiemann,et al. Src phosphorylates Tyr284 in tgf-β type II receptor and regulates TGF-β stimulation of p38 MAPK during breast cancer cell proliferation and invasion , 2007 .
[172] S. Kuwada. Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody. , 2007, Current opinion in molecular therapeutics.
[173] A. Gown,et al. Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. , 2008, Cancer research.
[174] M. Imamura,et al. Expression of integrin alphaVbeta3 in pancreatic carcinoma: relation to MMP-2 activation and lymph node metastasis. , 2002, Pancreas.
[175] E. Ruoslahti,et al. A Signaling Pathway from the α5β1 and αvβ3 Integrins That Elevatesbcl-2 Transcription* , 2001, The Journal of Biological Chemistry.
[176] D. Stupack,et al. Role of Raf in Vascular Protection from Distinct Apoptotic Stimuli , 2003, Science.
[177] Kenneth M. Yamada,et al. Cell–matrix adhesion , 2007, Journal of cellular physiology.
[178] P. Black,et al. αvβ3 and αvβ5 Integrin Expression in Glioma Periphery , 2001 .
[179] S. Kitazawa,et al. Integrin αvβ3 Expression by Bone‐residing Breast Cancer Metastases , 1996 .
[180] D. Cheresh,et al. Integrin α v β 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels , 1994, Cell.
[181] L. Ellis,et al. αvβ3 Integrin Antagonist S247 Decreases Colon Cancer Metastasis and Angiogenesis and Improves Survival in Mice , 2003 .
[182] Wenjun Guo,et al. Integrin signalling during tumour progression , 2004, Nature Reviews Molecular Cell Biology.
[183] S. Barry,et al. The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3. , 2003, The Biochemical journal.
[184] F. Aoudjit,et al. Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells , 2001, Oncogene.
[185] R. Juliano,et al. Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. , 1995, Molecular biology of the cell.
[186] Liz Y. Han,et al. Tumor-selective response to antibody-mediated targeting of αvβ3 integrin in ovarian cancer , 2008 .
[187] L. Silengo,et al. Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion‐dependent cell survival , 1998, The EMBO journal.
[188] R. Cardiff,et al. Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression , 2007, Proceedings of the National Academy of Sciences.
[189] D. Taverna,et al. Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins , 2002, Nature Medicine.
[190] N. Watanabe,et al. Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3 , 2006, Current Biology.
[191] R. Klemke,et al. Receptor Tyrosine Kinase Signaling Required for Integrin c v/35-directed Cell Motility but Not Adhesion on Vitronectin , 1994 .
[192] P. Kiener,et al. Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, Abegrin™ , 2006, Molecular Cancer Therapeutics.
[193] D. Elder,et al. Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression. , 1990, Cancer research.
[194] D. Shaw,et al. A non–RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo , 2006, Molecular Cancer Therapeutics.
[195] T. Byzova,et al. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. , 2000, Molecular cell.
[196] D. Elder,et al. Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma. , 1998, The American journal of pathology.
[197] K. Pienta,et al. Expression and activation of αvβ3 integrins by SDF‐1/CXC12 increases the aggressiveness of prostate cancer cells , 2007 .
[198] E. Raymond,et al. Phase I and pharmacokinetic study of etaracizumab (Abegrin™), a humanized monoclonal antibody against αvβ3 integrin receptor, in patients with advanced solid tumors , 2008, Investigational New Drugs.
[199] R. Klemke,et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5- directed cell motility but not adhesion on vitronectin , 1994, The Journal of cell biology.