The Distribution of HLA B27 in Patients with Ankylosing Spondylitis in Eastern Anatolia

Ankilozan spondilit (AS) etyolojisi bilinmeyen kronik enflamatuvar bir hastaliktir. Patogenezde genetik ve cevresel faktorlerin onemli rol oynadigi bilinmektedir. AS gelisimi ile HLA B27 arasinda guclu bir birliktelik saptanmistir. Bu calisma ile daha onceki literatur bilgileri isiginda bolgemizdeki HLA B27-AS iliskisi karsilastirildi. Bu calismada, modifiye New York kritelerine gore siniflandirilmis AS’li hasta ve saglikli kontroller uzerinde HLA B27 frekansi arastirilmistir. Calismaya birbirleri ile akraba olmayan 84 AS’li hasta ile 73 gonullu kemik iligi donoru dahil edildi. HLA B27 tiplendirilmesi PCR-SSP yontemi ile belirlendi. Elde edilen bulgulara gore calismaya alinan AS’li hastalarin yas ortalamasi 31±11yil olarak bulundu. Ayni grupta erkeklerde (%39.3) HLA B27 frekansi kadinlardan (%19.0) cok daha yuksekti. Ankilozan spondilitli hastalar (%58,3) ile kontrol grubu (%4.3) karsilastirildiginda hasta grubunda HLA B27 pozitifli ginin yuksek oldu u goruldu (p<0.05). Sonuc olarak AS hastalarinda HLA B27 frekansinin saglikli bireylerden daha yuksek oldugu gorulmektedir. Dogu Anadolu Bolgesinin hasta populasyonunda HLA B27 pozitifligi, literaturde verilen diger oranlardan daha dusuk olabilir. Bu durumu inceleyecek yeni klinik calismalarin yapilmasi faydali olacaktir.

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