Reappraisal of clinical data supports double IUI for improved pregnancy outcomes

Optimising pregnancy and live birth outcomes for fertility procedures is highly desirable and involves disentangling numerous potentially contributing factors. In IUI procedures would double inseminations within a cycle be beneficial? Despite mistaken belief amongst the fertility practitioners the available evidence including Cochrane review has suggested, there would be beneficial effects of utilising double IUI within a cycle. Here we examine new evidence attempting to clarify the role of double versus single IUI.

[1]  B. Fauser,et al.  Response from the Editors: time-lapse systems for ART - meta-analyses and the issue of bias. , 2017, Reproductive biomedicine online.

[2]  A. Tanghe,et al.  Cost-effectiveness of ovarian stimulation with gonadotrophin and clomiphene citrate in an intrauterine insemination programme for subfertile couples. , 2017, Reproductive biomedicine online.

[3]  Julie Brown,et al.  Intrauterine insemination with ovarian stimulation versus expectant management for unexplained infertility (TUI): a pragmatic, open-label, randomised, controlled, two-centre trial , 2017, The Lancet.

[4]  W. Ombelet.  The revival of intrauterine insemination: evidence-based data have changed the picture , 2017, Facts, views & vision in ObGyn.

[5]  R. Homburg,et al.  A New Dawn for Intrauterine Insemination: Efficient and Prudent Practice will Benefit Patients, the Fertility Industry and the Healthcare Bodies , 2017, The Journal of Obstetrics and Gynecology of India.

[6]  A. Muneer,et al.  Pitfalls of NICE recommendations on fertility treatment , 2017, British Medical Journal.

[7]  D. Nunan,et al.  Lack of evidence for interventions offered in UK fertility centres , 2016, British Medical Journal.

[8]  A. Muneer,et al.  First line fertility treatment strategies regarding IUI and IVF require clinical evidence. , 2016, Human reproduction.

[9]  Mohamad Hassan,et al.  The effects of timing of intrauterine insemination in relation to ovulation and the number of inseminations on cycle pregnancy rate in common infertility etiologies. , 2011, Human reproduction.

[10]  B. Haydardedeoglu,et al.  Single versus double intrauterine insemination in multi-follicular ovarian hyperstimulation cycles: a randomized trial. , 2010, Human reproduction.

[11]  P. Gantt,et al.  Double vs. single intrauterine insemination per cycle: use in gonadotropin cycles and in diagnostic categories of ovulatory dysfunction and male factor infertility. , 2008, The Journal of reproductive medicine.

[12]  Wei Liu,et al.  Comparing the pregnancy rates of one versus two intrauterine inseminations (IUIs) in male factor and idiopathic infertility , 2006, Journal of Assisted Reproduction and Genetics.

[13]  R. Matorras,et al.  One versus two inseminations per cycle in intrauterine insemination with sperm from patients' husbands: a systematic review of the literature. , 2004, Fertility and sterility.

[14]  M. Heineman,et al.  Single versus double intrauterine insemination in stimulated cycles for subfertile couples: a systematic review based on a Cochrane review. , 2003, Human reproduction.

[15]  M. Heineman,et al.  Single versus double intrauterine insemination (IUI) in stimulated cycles for subfertile couples. , 2003, The Cochrane database of systematic reviews.

[16]  G. Cope.  A new dawn , 2007 .