pH‐Stimulated DNA Hydrogels Exhibiting Shape‐Memory Properties

Nucleic acid-functionalized polyacrylamide chains that are cooperatively cross-linked by i-motif and nucleic acid duplex units yield, at pH 5.0, DNA hydrogels exhibiting shape-memory properties. Separation of the i-motif units at pH 8.0 dissolves the hydrogel into a quasi-liquid phase. The residual duplex units provide, however, a memory code in the quasi-liquid allowing the regeneration of the hydrogel shape at pH 5.0.

[1]  Wei Wang,et al.  Zinc ion-triggered two-way macro-/microscopic shape changing and memory effects in high strength hydrogels with pre-programmed unilateral patterned surfaces , 2012 .

[2]  From cells to DNA materials , 2012 .

[3]  H. Meng,et al.  A review of stimuli-responsive shape memory polymer composites , 2013 .

[4]  M. Maskos,et al.  Switchable information carriers based on shape memory polymer , 2012 .

[5]  W. M. Huang,et al.  Shaping tissue with shape memory materials. , 2013, Advanced drug delivery reviews.

[6]  Melodie F Metzger,et al.  Photothermal properties of shape memory polymer micro‐actuators for treating stroke * , 2002, Lasers in surgery and medicine.

[7]  Jong Bum Lee,et al.  Engineering DNA-based functional materials. , 2011, Chemical Society reviews.

[8]  D. Luo,et al.  A mechanical metamaterial made from a DNA hydrogel. , 2012, Nature nanotechnology.

[9]  Robert Langer,et al.  From Advanced Biomedical Coatings to Multi‐Functionalized Biomaterials , 2006 .

[10]  John M. Hoffman,et al.  Rewritable and shape-memory soft matter with dynamically tunable microchannel geometry in a biological temperature range , 2013 .

[11]  Patrick T. Mather,et al.  Review of progress in shape-memory polymers , 2007 .

[12]  Itamar Willner,et al.  Switchable catalytic acrylamide hydrogels cross-linked by hemin/G-quadruplexes. , 2013, Nano letters.

[13]  R. Langer,et al.  Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications , 2002, Science.

[14]  Juewen Liu.  Oligonucleotide-functionalized hydrogels as stimuli responsive materials and biosensors , 2011 .

[15]  Tao Zhang,et al.  Self‐Assembled DNA Hydrogels with Designable Thermal and Enzymatic Responsiveness , 2011, Advanced materials.

[16]  R. Langer,et al.  Light-induced shape-memory polymers , 2005, Nature.

[17]  Chaoyong James Yang,et al.  DNAzyme crosslinked hydrogel: a new platform for visual detection of metal ions. , 2011, Chemical communications.

[18]  S. Smoukov,et al.  Electro-mechanical actuator with muscle memory , 2014 .

[19]  Dongsheng Liu,et al.  A pH-triggered, fast-responding DNA hydrogel. , 2009, Angewandte Chemie.

[20]  Soong Ho Um,et al.  Enzyme-catalysed assembly of DNA hydrogel , 2006, Nature materials.

[21]  Bryan Wei,et al.  Aptamer based reversible DNA induced hydrogel system for molecular recognition and separation. , 2010, Chemical communications.

[22]  G. Manzini,et al.  Evidence for intramolecularly folded i-DNA structures in biologically relevant CCC-repeat sequences. , 1994, Nucleic acids research.

[23]  Melanie Ecker,et al.  Multifunctional poly(ester urethane) laminates with encoded information , 2014 .

[24]  Juewen Liu,et al.  Electrostatically directed visual fluorescence response of DNA-functionalized monolithic hydrogels for highly sensitive Hg²+ detection. , 2011, ACS applied materials & interfaces.

[25]  Nam Seo Goo,et al.  Development and application of conducting shape memory polyurethane actuators , 2006 .

[26]  Martin L. Dunn,et al.  Thermomechanical behavior of a two-way shape memory composite actuator , 2013 .

[27]  A. Lendlein,et al.  Initiation of shape-memory effect by inductive heating of magnetic nanoparticles in thermoplastic polymers. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[28]  R. Vaia,et al.  Remotely actuated polymer nanocomposites—stress-recovery of carbon-nanotube-filled thermoplastic elastomers , 2004, Nature materials.

[29]  Marc Behl,et al.  Recent Trends in the Chemistry of Shape‐Memory Polymers , 2013 .

[30]  Marc Behl,et al.  Shape-Memory Polymers and Shape-Changing Polymers , 2009 .

[31]  Christoph Weder,et al.  Shape memory polymers with built-in threshold temperature sensors , 2008 .

[32]  M. Guéron,et al.  A tetrameric DNA structure with protonated cytosine-cytosine base pairs , 1993, Nature.

[33]  Kinam Park,et al.  Environment-sensitive hydrogels for drug delivery , 2001 .

[34]  Yong Wang,et al.  Aptamer-functionalized in situ injectable hydrogel for controlled protein release. , 2010, Biomacromolecules.

[35]  F. Simmel,et al.  Controlled trapping and release of quantum dots in a DNA-switchable hydrogel. , 2007, Small.

[36]  Andreas Herrmann,et al.  Nucleic acid/organic polymer hybrid materials: synthesis, superstructures, and applications. , 2010, Angewandte Chemie.

[37]  Cuichen Wu,et al.  Responsive DNA-based hydrogels and their applications. , 2013, Macromolecular rapid communications.