Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.

[1]  A. Shiratsuchi,et al.  Evidence for Phagocytosis of Influenza Virus-Infected, Apoptotic Cells by Neutrophils and Macrophages in Mice1 , 2007, The Journal of Immunology.

[2]  Hubertus Hochrein,et al.  Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells. , 2007, Blood.

[3]  Y. Nagai,et al.  Importance of the Anti-Interferon Capacity of Sendai Virus C Protein for Pathogenicity in Mice , 2007, Journal of Virology.

[4]  Gunther Hartmann,et al.  5'-Triphosphate RNA Is the Ligand for RIG-I , 2006, Science.

[5]  A. Pichlmair,et al.  RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates , 2006, Science.

[6]  S. Akira,et al.  Cutting Edge: Role of TANK-Binding Kinase 1 and Inducible IκB Kinase in IFN Responses against Viruses in Innate Immune Cells1 , 2006, The Journal of Immunology.

[7]  K. Honda,et al.  Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors , 2006 .

[8]  Jennifer Louten,et al.  Type 1 IFN Deficiency in the Absence of Normal Splenic Architecture during Lymphocytic Choriomeningitis Virus Infection1 , 2006, The Journal of Immunology.

[9]  R. Medzhitov,et al.  Type I interferons in host defense. , 2006, Immunity.

[10]  V. Pascual,et al.  Type I interferon in systemic lupus erythematosus and other autoimmune diseases. , 2006, Immunity.

[11]  C. Coban,et al.  Essential role of IPS-1 in innate immune responses against RNA viruses , 2006, The Journal of experimental medicine.

[12]  K. Ishii,et al.  Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses , 2006, Nature.

[13]  Hong-Hsing Liu,et al.  The specific and essential role of MAVS in antiviral innate immune responses. , 2006, Immunity.

[14]  S. Akira,et al.  IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9 , 2006, Nature.

[15]  S. Akira,et al.  Pathogen Recognition and Innate Immunity , 2006, Cell.

[16]  Shizuo Akira,et al.  Innate immune recognition of viral infection , 2006, Nature Immunology.

[17]  P. Opolon,et al.  A novel dendritic cell subset involved in tumor immunosurveillance , 2006, Nature Medicine.

[18]  L. Lanier,et al.  Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity , 2006, Nature Medicine.

[19]  Ralf Bartenschlager,et al.  Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus , 2005, Nature.

[20]  Osamu Takeuchi,et al.  IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction , 2005, Nature Immunology.

[21]  Z. Zhai,et al.  VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling , 2005 .

[22]  Zhijian J. Chen,et al.  Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 , 2005, Cell.

[23]  K. Matsushima,et al.  Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs , 2005, The Journal of experimental medicine.

[24]  Osamu Takeuchi,et al.  Cell type-specific involvement of RIG-I in antiviral response. , 2005, Immunity.

[25]  D. Levy,et al.  Tissue-specific Positive Feedback Requirements for Production of Type I Interferon following Virus Infection* , 2005, Journal of Biological Chemistry.

[26]  Hideo Negishi,et al.  IRF-7 is the master regulator of type-I interferon-dependent immune responses , 2005, Nature.

[27]  G. Trinchieri,et al.  Type I interferon dependence of plasmacytoid dendritic cell activation and migration , 2005, The Journal of experimental medicine.

[28]  C. Coban,et al.  Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction , 2005, The Journal of experimental medicine.

[29]  K. Honda,et al.  Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[30]  C. Coban,et al.  Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 , 2004, Nature Immunology.

[31]  H. Hammad,et al.  Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen , 2004, The Journal of experimental medicine.

[32]  M. Peters-Golden.  The alveolar macrophage: the forgotten cell in asthma. , 2004, American journal of respiratory cell and molecular biology.

[33]  Shizuo Akira,et al.  The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses , 2004, Nature Immunology.

[34]  Persephone Borrow,et al.  Viral infection switches non-plasmacytoid dendritic cells into high interferon producers , 2003, Nature.

[35]  G. Trinchieri,et al.  Interferon / and Interleukin 12 Responses to Viral Infections: Pathways Regulating Dendritic Cell Cytokine Expression In Vivo , 2002 .

[36]  M. Colonna,et al.  Virus-induced Interferon α Production by a Dendritic Cell Subset in the Absence of Feedback Signaling In Vivo , 2002, The Journal of experimental medicine.

[37]  S. Akira,et al.  Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway , 2002, Nature Immunology.

[38]  P Björck,et al.  Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. , 2001, Blood.

[39]  Marc Dalod,et al.  Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology , 2001, Nature Immunology.

[40]  M. Gunn,et al.  Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells , 2001, The Journal of experimental medicine.

[41]  D. Woodland,et al.  Cellular immunity and memory to respiratory virus infections , 2001, Immunologic research.

[42]  D. Jarrossay,et al.  Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon , 1999, Nature Medicine.

[43]  N. Kadowaki,et al.  The nature of the principal type 1 interferon-producing cells in human blood. , 1999, Science.

[44]  S. Akira,et al.  Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. , 1998, Immunity.

[45]  N. Van Rooijen,et al.  Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice , 1989, The Journal of experimental medicine.