Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction

[1]  Arthur W. Toga,et al.  Neuroanatomical morphometric characterization of sex differences in youth using statistical learning , 2018, NeuroImage.

[2]  F. Liu,et al.  Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents , 2018, Neuron.

[3]  C. Jack,et al.  NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease , 2018, Alzheimer's & Dementia.

[4]  Koji Ando,et al.  A molecular atlas of cell types and zonation in the brain vasculature , 2018, Nature.

[5]  Berislav V. Zlokovic,et al.  Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders , 2018, Nature Reviews Neurology.

[6]  Tim Clark,et al.  Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease , 2018, Proceedings of the National Academy of Sciences.

[7]  B. Zlokovic,et al.  Alzheimer’s disease: A matter of blood–brain barrier dysfunction? , 2017, The Journal of experimental medicine.

[8]  C. Iadecola The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease , 2017, Neuron.

[9]  Axel Montagne,et al.  Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease , 2017, Nature Reviews Neuroscience.

[10]  A. Rahmim,et al.  Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition , 2017, JAMA.

[11]  K. Blennow,et al.  Tau oligomers in cerebrospinal fluid in Alzheimer's disease , 2017, Annals of clinical and translational neurology.

[12]  Adam J. Woods,et al.  Cognitive Aging and the Hippocampus in Older Adults , 2016, Front. Aging Neurosci..

[13]  Brian A. Gordon,et al.  Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology. , 2016, JAMA neurology.

[14]  Walter H. Backes,et al.  Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging , 2016, Neurobiology of Aging.

[15]  Norbert Schuff,et al.  Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis , 2016, Nature Communications.

[16]  David A. Bennett,et al.  Relation of Cerebral Vessel Disease to Alzheimer’s Disease Dementia and Cognitive Function in Older Persons: A Cross-sectional Study , 2016, The Lancet Neurology.

[17]  Walter H Backes,et al.  Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease. , 2016, Radiology.

[18]  Knut Waterloo,et al.  Neuroanatomical correlates of verbal fluency in early Alzheimer’s disease and normal aging , 2016, Brain and Language.

[19]  P. Wolf,et al.  Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study , 2016, Journal of the International Neuropsychological Society.

[20]  Herbert A. Reitsamer,et al.  Brain and Retinal Pericytes: Origin, Function and Role , 2016, Front. Cell. Neurosci..

[21]  B. Zlokovic,et al.  Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes , 2015, Neuroscience Letters.

[22]  O. Monchi,et al.  Neuroimaging studies of the striatum in cognition Part I: healthy individuals , 2015, Front. Syst. Neurosci..

[23]  Russell E. Jacobs,et al.  ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies , 2015, BMC Medical Imaging.

[24]  J. Schneider,et al.  Vascular contributions to cognitive impairment and dementia including Alzheimer's disease , 2015, Alzheimer's & Dementia.

[25]  B. Zlokovic,et al.  Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[26]  D. Salmon,et al.  Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease , 2015, Alzheimer's & Dementia.

[27]  Stefano Fusi,et al.  Hippocampal-prefrontal input supports spatial encoding in working memory , 2015, Nature.

[28]  T. Hendler,et al.  Distinct functional connectivity of the hippocampus during semantic and phonemic fluency , 2015, Neuropsychologia.

[29]  C. Dickey,et al.  Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy , 2015, Acta neuropathologica communications.

[30]  Arthur W. Toga,et al.  Blood-Brain Barrier Breakdown in the Aging Human Hippocampus , 2015, Neuron.

[31]  T. Montine,et al.  Diagnostic Values of Cerebrospinal Fluid T-Tau and Aβ₄₂ using Meso Scale Discovery Assays for Alzheimer's Disease. , 2015, Journal of Alzheimer's disease : JAD.

[32]  Mark R Schultz,et al.  False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies. , 2014, Journal of clinical epidemiology.

[33]  D. Drachman The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease , 2014, Alzheimer's & Dementia.

[34]  D. Salmon,et al.  Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates. , 2014, Journal of Alzheimer's disease : JAD.

[35]  Andrei G. Vlassenko,et al.  Quantitative Analysis of PiB-PET with FreeSurfer ROIs , 2013, PloS one.

[36]  J. Trojanowski,et al.  Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. , 2013, Brain : a journal of neurology.

[37]  Nick C Fox,et al.  Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration , 2013, The Lancet Neurology.

[38]  K. Blennow,et al.  Evaluating Amyloid-β Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer’s Disease , 2013, PloS one.

[39]  A. Fagan,et al.  Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later , 2013, Alzheimer's & Dementia.

[40]  Bruce Fischl,et al.  FreeSurfer , 2012, NeuroImage.

[41]  D. Salmon,et al.  Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer's disease. , 2012, Journal of Alzheimer's disease : JAD.

[42]  B. Zlokovic Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders , 2011, Nature Reviews Neuroscience.

[43]  B. Barres,et al.  Pericytes are required for blood–brain barrier integrity during embryogenesis , 2010, Nature.

[44]  Bengt R. Johansson,et al.  Pericytes regulate the blood–brain barrier , 2010, Nature.

[45]  Berislav V. Zlokovic,et al.  Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging , 2010, Neuron.

[46]  D. Stott Parker,et al.  Neuroimaging Study Designs, Computational Analyses and Data Provenance Using the LONI Pipeline , 2010, PloS one.

[47]  B. Zlokovic,et al.  Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling , 2010, Molecular Neurodegeneration.

[48]  C. Blobel,et al.  Stimulation of Platelet-derived Growth Factor Receptor β (PDGFRβ) Activates ADAM17 and Promotes Metalloproteinase-dependent Cross-talk between the PDGFRβ and Epidermal Growth Factor Receptor (EGFR) Signaling Pathways* , 2010, The Journal of Biological Chemistry.

[49]  D. Delis,et al.  Quantification of five neuropsychological approaches to defining mild cognitive impairment. , 2009, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[50]  Jessica A. Grahn,et al.  The cognitive functions of the caudate nucleus , 2008, Progress in Neurobiology.

[51]  Pedagógia,et al.  Cross Sectional Study , 2019 .

[52]  Anders M. Dale,et al.  An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest , 2006, NeuroImage.

[53]  Timothy Edward John Behrens,et al.  Quantitative Investigation of Connections of the Prefrontal Cortex in the Human and Macaque using Probabilistic Diffusion Tractography , 2005, The Journal of Neuroscience.

[54]  A. Dale,et al.  Whole Brain Segmentation Automated Labeling of Neuroanatomical Structures in the Human Brain , 2002, Neuron.

[55]  A M Dale,et al.  Measuring the thickness of the human cerebral cortex from magnetic resonance images. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[56]  K. Blennow,et al.  Cerebrospinal fluid markers of pathogenetic processes in vascular dementia, with special reference to the subcortical subtype. , 1999, Alzheimer disease and associated disorders.

[57]  A. Dale,et al.  High‐resolution intersubject averaging and a coordinate system for the cortical surface , 1999, Human brain mapping.

[58]  B R Johansson,et al.  Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. , 1997, Science.

[59]  P. Wesseling,et al.  Induction of alpha-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-beta 1. , 1994, The American journal of pathology.

[60]  D. Delis,et al.  The California verbal learning test , 2016 .

[61]  C. Patlak,et al.  Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[62]  C S Patlak,et al.  Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.