Place memory is intact in rats with perirhinal cortex lesions.

Two experiments compared the effects of bilateral lesions of the hippocampal formation (HPC) or perirhinal cortex (PRh) on rats' performance of an allocentric spatial working memory task--delayed matching-to-place (DMTP) in a water maze. DMTP trials consisted of paired swims, and the hidden platform was moved to a new location on each trial. Performance was assessed with intervals between the first and second swim (i.e., retention delays) of 4, 30, 120, and 300 s. The rats received extensive presurgery training in Experiment 1 and no presurgery training in Experiment 2. In both experiments, rats with HPC lesions displayed DMTP deficits at all delays, taking longer and swimming farther to find the platform on the second swims than did sham-operated controls. By contrast, rats with PRh lesions displayed normal DMTP acquisition and performance. The results suggest that, unlike the functions of HPC, those of PRh are not critical for allocentric spatial working memory.

[1]  L. Jarrard.  On the role of the hippocampus in learning and memory in the rat. , 1993, Behavioral and neural biology.

[2]  Elisabeth A. Murray,et al.  What have ablation studies told us about the neural substrates of stimulus memory , 1996 .

[3]  E. Wood,et al.  Object-recognition memory is only mildly impaired in rats with lesions of the hippocampus and amygdala , 1992, Psychobiology.

[4]  D. Amaral,et al.  Perirhinal and postrhinal cortices of the rat: A review of the neuroanatomical literature and comparison with findings from the monkey brain , 1995, Hippocampus.

[5]  M. Gallagher,et al.  Entorhinal-perirhinal lesions impair performance of rats on two versions of place learning in the Morris water maze. , 1995, Behavioral neuroscience.

[6]  D. Gaffan,et al.  Interaction of Perirhinal Cortex with the Fornix–Fimbria: Memory for Objects and “Object-in-Place” Memory , 1996, The Journal of Neuroscience.

[7]  H Eichenbaum,et al.  Afferent connections of the perirhinal cortex in the rat , 1983, The Journal of comparative neurology.

[8]  R. Morris.  Spatial Localization Does Not Require the Presence of Local Cues , 1981 .

[9]  L. F. Kromer,et al.  Object recognition memory in the rat: the role of the hippocampus , 1991, Behavioural Brain Research.

[10]  Wendy A Suzuki,et al.  The anatomy, physiology and functions of the perirhinal cortex , 1996, Current Opinion in Neurobiology.

[11]  E. Murray,et al.  Preserved Recognition Memory for Small Sets, and Impaired Stimulus Identification for Large Sets, Following Rhinal Cortex Ablations in Monkeys , 1994, The European journal of neuroscience.

[12]  G. V. Hoesen,et al.  A direct projection from the perirhinal cortex (area 35) to the subiculum in the rat , 1983, Brain Research.

[13]  D. Amaral,et al.  Cortical inputs to the CA1 field of the monkey hippocampus originate from the perirhinal and parahippocampal cortex but not from area TE , 1990, Neuroscience Letters.

[14]  R. Morris,et al.  Place navigation impaired in rats with hippocampal lesions , 1982, Nature.

[15]  D. Amaral,et al.  Perirhinal and postrhinal cortices of the rat: Interconnectivity and connections with the entorhinal cortex , 1998, The Journal of comparative neurology.

[16]  Seth J. Ramus,et al.  Severity of memory impairment in monkeys as a function of locus and extent of damage within the medial temporal lobe memory system , 1994, Hippocampus.

[17]  J. Bolhuis,et al.  Retrograde Amnesia and Memory Reactivation in Rats with Ibotenate Lesions to the Hippocampus or Subiculum , 1994, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[18]  M W Brown,et al.  Mapping visual recognition memory through expression of the immediate early gene c-fos. , 1996, Neuroreport.

[19]  J. Aggleton,et al.  Neurotoxic lesions of the perirhinal cortex do not mimic the behavioural effects of fornix transection in the rat , 1996, Behavioural Brain Research.

[20]  R. J. McDonald,et al.  Dissociation of the medial prefrontal, posterior parietal, and posterior temporal cortex for spatial navigation and recognition memory in the rat. , 1994, Cerebral cortex.

[21]  D. Mumby,et al.  Rhinal cortex lesions and object recognition in rats. , 1994, Behavioral neuroscience.

[22]  D. Amaral,et al.  Lesions of perirhinal and parahippocampal cortex that spare the amygdala and hippocampal formation produce severe memory impairment , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[23]  M. Mishkin,et al.  Stimulus recognition , 1994, Current Opinion in Neurobiology.

[24]  E. Murray,et al.  Monkeys (Macaca fascicularis) with rhinal cortex ablations succeed in object discrimination learning despite 24-hr intertrial intervals and fail at matching to sample despite double sample presentations. , 1992, Behavioral neuroscience.

[25]  L. Squire.  Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. , 1992, Psychological review.

[26]  M. Witter,et al.  Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region , 1989, Progress in Neurobiology.

[27]  M. W. Brown.  Neuronal responses and recognition memory , 1996 .

[28]  R. Passingham.  The hippocampus as a cognitive map J. O'Keefe & L. Nadel, Oxford University Press, Oxford (1978). 570 pp., £25.00 , 1979, Neuroscience.

[29]  R. Hirsh.  The hippocampus and contextual retrieval of information from memory: a theory. , 1974, Behavioral biology.

[30]  R. Sutherland,et al.  A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat , 1983, Behavioural Brain Research.

[31]  M Meunier,et al.  Effects of rhinal cortex lesions combined with hippocampectomy on visual recognition memory in rhesus monkeys. , 1996, Journal of neurophysiology.

[32]  D. Amaral,et al.  The entorhinal cortex of the monkey: II. Cortical afferents , 1987, The Journal of comparative neurology.

[33]  C. Barnes.  Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat , 1988, Trends in Neurosciences.

[34]  D. Bilkey,et al.  The effects of perirhinal cortical lesions on spatial reference memory in the rat , 1994, Behavioural Brain Research.

[35]  D. Stein,et al.  Sparing and recovery of spatial alternation performance after entorhinal cortex lesions in rats , 1984, Behavioural Brain Research.

[36]  H. Eichenbaum,et al.  Two functional components of the hippocampal memory system , 1994, Behavioral and Brain Sciences.

[37]  M. Mishkin,et al.  Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[38]  Tim Otto,et al.  Combined Lesions of Perirhinal and Entorhinal Cortex Impair Rats’ Performance in Two Versions of the Spatially Guided Radial-Arm Maze , 1997, Neurobiology of Learning and Memory.

[39]  Charles R. Goodlett,et al.  Long-term deficits in water maze spatial conditional alternation performance following retrohippocampal lesions in rats , 1989, Behavioural Brain Research.