Bridging the gap between basic science and clinical practice: The role of organizations in addressing clinician barriers

BackgroundNew National Institutes of Health policies call for expansion of practice-based research to improve the clinical research enterprise and facilitate dissemination of evidence-based medicine.ObjectiveThis paper describes organizational strategies that influence clinicians' decisions to participate in clinical research.DesignWe reviewed the literature and interviewed over 200 clinicians and stakeholders.ResultsThe most common barriers to community clinician participation in clinical research relate to beliefs that clinical research is too burdensome and has little benefit for the participating clinician or patient. We identified a number of approaches healthcare organizations can use to encourage clinicians to participate in research, including an outreach campaign to promote the benefits of clinical research; selection of study topics of interest to clinicians; establishment and enforcement of a set of research principles valuing the clinician and patient; development of a transparent schedule of reimbursement for research tasks; provision of technological and technical assistance to practices as needed; and promotion of a sense of community among clinicians involved in practice-based research.ConclusionsMany types of existing healthcare organizations could provide the technical and intellectual assistance community clinicians need to participate in clinical research. Multiple approaches are possible.

[1]  Kevin A Peterson,et al.  Primary Care Practice-Based Research Networks: Working at the Interface Between Research and Quality Improvement , 2005, The Annals of Family Medicine.

[2]  G. Woody,et al.  MET meets the real world: design issues and clinical strategies in the Clinical Trials Network. , 2002, Journal of substance abuse treatment.

[3]  A. Rademaker,et al.  Oncologists' reluctance to accrue patients onto clinical trials: an Illinois Cancer Center study. , 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  A. Mainous,et al.  Characteristics of community-based primary care physicians participating in research. , 1995, The Journal of family practice.

[5]  L. Siu,et al.  Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  D. Stryer,et al.  Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. , 2003, JAMA.

[7]  Strategies to improve diabetes care. , 2003, American family physician.

[8]  J E Heffner,et al.  Altering physician behavior to improve clinical performance. , 2001, Topics in health information management.

[9]  Stephen B. Johnson,et al.  Central challenges facing the national clinical research enterprise. , 2003, JAMA.

[10]  J. Prochaska,et al.  Stages and processes of self-change of smoking: toward an integrative model of change. , 1983, Journal of consulting and clinical psychology.

[11]  R. Hornung,et al.  Effect of a clinical trial alert system on physician participation in trial recruitment. , 2005, Archives of internal medicine.

[12]  M. Lahey,et al.  Increasing the Involvement of Specialist Physicians in Chronic Disease Management , 2008, Journal of health services research & policy.

[13]  D Blumenthal,et al.  Status of clinical research in academic health centers: views from the research leadership. , 2001, JAMA.

[14]  K. Kahn,et al.  Bridging the gap between basic science and clinical practice: a role for community clinicians , 2011, Implementation science : IS.

[15]  K. Hofman,et al.  Implementation Science , 2007, Science.

[16]  C. van Weel,et al.  Longitudinal Research and Data Collection in Primary Care , 2005, The Annals of Family Medicine.

[17]  B. Worrall,et al.  Practice-based clinical research and ethical decision making--Part I: deciding whether to incorporate practice-based research into your clinical practice. , 2006, Seminars in neurology.

[18]  B. Cassileth Clinical trials: time for action. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[19]  J. E. Beach Clinical trials integrity: A CRO perspective , 2001, Accountability in research.

[20]  K. Peterson,et al.  Strategies to improve diabetes care delivery. , 1998, The Journal of family practice.

[21]  E. Zerhouni The NIH Roadmap , 2003, Science.

[22]  D. Korn,et al.  Promoting Translational and Clinical Science: The Critical Role of Medical Schools and Teaching Hospitals , 2006, PLoS medicine.

[23]  In search of evidence: is there the will and a way? , 2005, Archives of internal medicine.

[24]  R. Prescott,et al.  Barriers to participation in randomised controlled trials: a systematic review. , 1999, Journal of clinical epidemiology.

[25]  E. Zerhouni US biomedical research: basic, translational, and clinical sciences. , 2005, JAMA.

[26]  W. McCaskill-Stevens,et al.  Physician perspectives on increasing minorities in cancer clinical trials: an Eastern Cooperative Oncology Group (ECOG) Initiative. , 2000, Annals of epidemiology.

[27]  D. Gandara,et al.  Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[28]  Neeli Bendapudi,et al.  Strong leadership and teamwork drive culture and performance change: Ohio State University Medical Center 2000-2006. , 2008, Academic medicine : journal of the Association of American Medical Colleges.

[29]  Heffner Je Altering physician behavior to improve clinical performance. , 2001 .

[30]  Inder M. Verma,et al.  The NIH Roadmap , 2004 .

[31]  B. Delaney,et al.  General practice Randomised controlled trials in primary care : case study , 2022 .

[32]  P. Nutting,et al.  Practice-based research networks answer primary care questions. , 1999, JAMA.