STIM1 is required for attenuation of PMCA‐mediated Ca2+ clearance during T‐cell activation

T‐cell activation involves a complex signalling cascade uniquely dependent on elevated cytosolic Ca2+ levels. Further, the spatiotemporal characteristics of this Ca2+ signal play a critical role in this process via selective activation of transcription factors. In T cells, store‐operated Ca2+ entry (SOCe) is the primary Ca2+ influx pathway; however, cytosolic Ca2+ concentration depends upon the balance between Ca2+ influx and extrusion. The plasma membrane Ca2+ ATPase (PMCA) has previously been identified as a critical player in Ca2+ clearance in T cells. Here, we provide data revealing both functional and physical links between the activation of stromal interacting molecule 1 (STIM1) and PMCA‐mediated Ca2+ clearance. Due to the ubiquitous expression of both STIM1 and PMCA, these findings have wide‐ranging implications for Ca2+ signalling in multiple cell types.