TDP‐43 pathology and functional deficits in wild‐type and ALS/FTD mutant cyclin F mouse models

Amyotrophic lateral sclerosis (ALS) is characterised by a progressive loss of upper and lower motor neurons leading to muscle weakness and eventually death. Frontotemporal dementia (FTD) presents clinically with significant behavioural decline. Approximately 10% of cases have a known family history, and disease‐linked mutations in multiple genes have been identified in FTD and ALS. More recently, ALS and FTD‐linked variants have been identified in the CCNF gene, which accounts for an estimated 0.6% to over 3% of familial ALS cases.

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