Blockchains for Secure Digitized Medicine

Blockchain as an emerging technology has been gaining in popularity, with more possible applications to utilize the technology in the near future. With the offer of a decentralized, distributed environment without the need for a third trusted party (TTP), blockchains are being used to solve issues in systems that are susceptible to cyberattacks. One possible field that could benefit from blockchains that researchers have been focusing on is healthcare. Current healthcare information systems face several challenges, such as fragmented patient data, centralized systems which are viewed as single points of attacks, and the lack of patient-oriented services. In this paper, we investigate and analyze recent literature related to the use of blockchains to tackle issues found in modern healthcare information systems. This is done to understand issues that researchers commonly focus on, to discover remaining areas of concern in any proposed solution, and to understand the possible directions of the integration of blockchains in healthcare and personalized medicine. Background information regarding blockchains and existing healthcare information systems is reviewed, followed by the methodology used in the preparation of this review, where the research questions to consider are stated. Afterwards, an analysis of the results is provided, concluding with a discussion of the remaining issues that need to be focused on, and how blockchains could benefit the healthcare sector and empower personalized medicine.

[1]  David Brindley,et al.  Design Choices and Trade-Offs in Health Care Blockchain Implementations: Systematic Review , 2019, Journal of medical Internet research.

[2]  Kim-Kwang Raymond Choo,et al.  Healthcare-Related Data in the Cloud: Challenges and Opportunities , 2016, IEEE Cloud Computing.

[3]  Chi-Ren Shyu,et al.  Applying Blockchain Technology for Health Information Exchange and Persistent Monitoring for Clinical Trials , 2018, AMIA.

[4]  Qun Jin,et al.  i-Blockchain: A Blockchain-Empowered Individual-Centric Framework for Privacy-Preserved Use of Personal Health Data , 2018, 2018 9th International Conference on Information Technology in Medicine and Education (ITME).

[5]  B. Larijani,et al.  Ethical Issues Surrounding Personalized Medicine: A Literature Review. , 2017, Acta medica Iranica.

[6]  Andrew Lippman,et al.  MedRec: Using Blockchain for Medical Data Access and Permission Management , 2016, 2016 2nd International Conference on Open and Big Data (OBD).

[7]  Thaier Hayajneh,et al.  Healthcare Blockchain System Using Smart Contracts for Secure Automated Remote Patient Monitoring , 2018, Journal of Medical Systems.

[8]  Wei Jiang,et al.  Healthcare Data Gateways: Found Healthcare Intelligence on Blockchain with Novel Privacy Risk Control , 2016, Journal of Medical Systems.

[9]  M. A. Engelhardt,et al.  Hitching Healthcare to the Chain: An Introduction to Blockchain Technology in the Healthcare Sector , 2017 .

[10]  N. Agoulmine,et al.  Towards using blockchain technology for eHealth data access management , 2017, 2017 Fourth International Conference on Advances in Biomedical Engineering (ICABME).

[11]  Rui Guo,et al.  Secure Attribute-Based Signature Scheme With Multiple Authorities for Blockchain in Electronic Health Records Systems , 2018, IEEE Access.

[12]  Michael L. Martini,et al.  Emerging Blockchain Technology Solutions for Modern Healthcare Infrastructure , 2019, Journal of Scientific Innovation in Medicine.

[13]  Kelechi G. Eze,et al.  Block chain Technology in Healthcare , 2018 .

[14]  Fusheng Wang,et al.  Data Management and Analytics for Medicine and Healthcare , 2016, Lecture Notes in Computer Science.

[15]  Douglas C. Schmidt,et al.  Metrics for assessing blockchain-based healthcare decentralized apps , 2017, 2017 IEEE 19th International Conference on e-Health Networking, Applications and Services (Healthcom).

[16]  Md. Zakirul Alam Bhuiyan,et al.  Privacy-friendly platform for healthcare data in cloud based on blockchain environment , 2019, Future Gener. Comput. Syst..

[17]  Abdul Wahab,et al.  Survey of Consensus Protocols , 2018, ArXiv.

[18]  P. Aggarwal,et al.  Ethical issues in electronic health records: A general overview , 2015, Perspectives in clinical research.

[19]  Burkhard Stiller,et al.  Blockchains everywhere - a use-case of blockchains in the pharma supply-chain , 2017, 2017 IFIP/IEEE Symposium on Integrated Network and Service Management (IM).

[20]  Ricardo Cruz-Correia,et al.  Personalised medicine challenges: quality of data , 2018, International Journal of Data Science and Analytics.

[21]  Charlotte A. Weaver,et al.  Enhancing patient safety and quality of care by improving the usability of electronic health record systems: recommendations from AMIA. , 2013, Journal of the American Medical Informatics Association : JAMIA.

[22]  Satoshi Nakamoto Bitcoin : A Peer-to-Peer Electronic Cash System , 2009 .

[23]  Jong Soo Choi,et al.  Cost-Benefit Analysis of Electronic Medical Record System at a Tertiary Care Hospital , 2013, Healthcare informatics research.

[24]  E. G. Cortes,et al.  Hospital information systems: a study of electronic patient records , 2011 .

[25]  Sergey P. Novikov,et al.  Blockchain and Smart Contracts in a Decentralized Health Infrastructure , 2018, 2018 IEEE International Conference "Quality Management, Transport and Information Security, Information Technologies" (IT&QM&IS).

[26]  Rune Hylsberg Jacobsen,et al.  Identity and Access Management with Blockchain in Electronic Healthcare Records , 2018, 2018 21st Euromicro Conference on Digital System Design (DSD).

[27]  Sunny King,et al.  PPCoin: Peer-to-Peer Crypto-Currency with Proof-of-Stake , 2012 .

[28]  Bitcoin Proof of Stake: A Peer-to-Peer Electronic Cash System , 2020 .

[29]  Badeia Jawhari,et al.  Barriers and facilitators to Electronic Medical Record (EMR) use in an urban slum , 2016, Int. J. Medical Informatics.

[30]  Badeia Jawhari,et al.  Benefits and challenges of EMR implementations in low resource settings: a state-of-the-art review , 2016, BMC Medical Informatics and Decision Making.

[31]  Fusheng Wang,et al.  How Blockchain Could Empower eHealth: An Application for Radiation Oncology - (Extended Abstract) , 2017, DMAH@VLDB.

[32]  N. Menachemi,et al.  Benefits and drawbacks of electronic health record systems , 2011 .

[33]  Chrissa McFarlane,et al.  Patientory : A Healthcare Peer-to-Peer EMR Storage Network v 1 . 1 , 2017 .

[34]  Qi Xia,et al.  A Blockchain-based Architecture Framework for Secure Sharing of Personal Health Data , 2018, 2018 IEEE 20th International Conference on e-Health Networking, Applications and Services (Healthcom).

[35]  Emad Rahim,et al.  Challenges in Healthcare Post-EMR Adoption , 2018 .

[36]  U. Krieger,et al.  Advanced block-chain architecture for e-health systems , 2017, 2017 IEEE 19th International Conference on e-Health Networking, Applications and Services (Healthcom).

[37]  Emad Abd-Elrahman,et al.  Multi-tier Blockchain Framework for IoT-EHRs Systems , 2018, EUSPN/ICTH.

[38]  Giovanni Schmid,et al.  Beyond Bitcoin: A Critical Look at Blockchain-Based Systems , 2017, Cryptogr..

[39]  Michael Devetsikiotis,et al.  Blockchains and Smart Contracts for the Internet of Things , 2016, IEEE Access.

[40]  Robert Likić,et al.  Opportunities for Use of Blockchain Technology in Medicine , 2018, Applied Health Economics and Health Policy.

[41]  Marko Hölbl,et al.  A Systematic Review of the Use of Blockchain in Healthcare , 2018, Symmetry.

[42]  Aisha Zahid Junejo,et al.  Applications of Blockchain Technology in Medicine and Healthcare: Challenges and Future Perspectives , 2019, Cryptogr..

[43]  Fusheng Wang,et al.  Secure and Trustable Electronic Medical Records Sharing using Blockchain , 2017, AMIA.

[44]  Josip Car,et al.  Blockchain Implementation in Health Care: Protocol for a Systematic Review , 2019, JMIR research protocols.

[45]  David Brindley,et al.  Implementing Blockchains for Efficient Health Care: Systematic Review , 2019, Journal of medical Internet research.

[46]  D. Dimitrov,et al.  Blockchain Applications for Healthcare Data Management , 2019, Healthcare informatics research.

[47]  Zibin Zheng,et al.  An Overview of Blockchain Technology: Architecture, Consensus, and Future Trends , 2017, 2017 IEEE International Congress on Big Data (BigData Congress).

[48]  Kim-Kwang Raymond Choo,et al.  Blockchain: A Panacea for Healthcare Cloud-Based Data Security and Privacy? , 2018, IEEE Cloud Computing.