Anorexigenic effects of adrenaline, amphetamine, and FMS 1A.

Adrenaline 0.15 mg/kg, amphetamine 2 mg/kg, and urinary anorexigen (FMS 1A) 60 mg/kg, administered by intraperitoneal injection (i.p.), produced approximately the same average decrease in the food intake of rats fed for 1 h daily. Noradrenaline 0.15 mg/kg produced a much smaller decrease in food intake, and isotonic saline produced no significant change. Repetition of injections of adrenaline and amphetamine every second day revealed some variation of the anorexigenic effect, but no extinction of it was apparent during 10 injections. No conditioning of the anorexia to a saline injection was observed either. In rats fed ad libitum, only FMS 1A had a prolonged anorexigenic effect which was still apparent after 48 h. Adrenaline and amphetamine had only a small effect on the 24-h food consumption, but adrenaline injected just before the beginning of the dark period reduced by 90% the food consumption of the following hour although the intake for the next 23 h was approximately normal. This indicates that the ...