Analysis of multi-channel microfluidics for serial dilution in lab-on-CMOS platforms

Lab-on-CMOS platforms provide a means to integrate microfluidics with biochips composed of various bioprobes immobilized on the surface of CMOS instrumentation chips. This paper outlines recent developments in lab-on-CMOS technologies and presents an analysis of the challenges to achieving accurate serial dilution of test samples over sensing elements in lab-on-CMOS platforms. Based on this analysis, sensing chambers, channel placements, mixers, and microchannel geometries were optimized to achieve rapid fluid exchange and well-controlled dilution ratios. Utilizing an analogous electric circuit model, the design of a four-channel microfluidic device is presented along with simulation results validating the capability of the device to achieve accurate serial dilution in four different sensing chambers. The resulting device enables simultaneous measurement of samples with different concentrations for rapid sensor or sample calibration in lab-on-CMOS applications.

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