Comparative Mouse Genomics Centers Consortium: the Mouse Genotype Database.

The Comparative Mouse Genomics Centers Consortium (CMGCC) is a branch of the Environmental Genome Project sponsored by the National Institute of Environmental Health Sciences (NIEHS) focusing upon the identification of human single nucleotide polymorphisms (SNPs) that may confer disease susceptibility within the human population. The goal of the CMGCC (http://www.niehs.nih.gov/cmgcc/) is to make genetic mouse models for human SNPs within cell cycle control, DNA replication and DNA repair genes that may be associated with human pathologies. In order to facilitate information sharing and analysis within the consortium a set of informatics resources have been generated to support the mouse model development efforts. The primary entry point for information about the mouse models developed by the consortium is through the CMGCC Genotype Database (http://mrages.niehs.nih.gov/genotype/), which maintains both a consortium specific and public access display of the available and developing mouse models.

[1]  J. Thacker The RAD51 gene family, genetic instability and cancer. , 2005, Cancer letters.

[2]  A. Brookes The essence of SNPs. , 1999, Gene.

[3]  C. Carlson,et al.  Mapping complex disease loci in whole-genome association studies , 2004, Nature.

[4]  S L Shalat,et al.  The Environmental Genome Project. , 1998, Epidemiology.

[5]  J. Campisi Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors , 2005, Cell.

[6]  D. Clayton,et al.  Genome-wide association studies: theoretical and practical concerns , 2005, Nature Reviews Genetics.

[7]  P. Brennan,et al.  Gene-environment interaction and aetiology of cancer: what does it mean and how can we measure it? , 2002, Carcinogenesis.

[8]  Muin J Khoury,et al.  The role of genetic polymorphisms in environmental health. , 2003, Environmental health perspectives.

[9]  R. Dumitrescu,et al.  Understanding breast cancer risk ‐ where do we stand in 2005? , 2005, Journal of cellular and molecular medicine.

[10]  A. Clark,et al.  The role of haplotypes in candidate gene studies , 2004, Genetic epidemiology.

[11]  C. Ulrich,et al.  Polymorphisms in DNA repair genes and associations with cancer risk. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[12]  F. Guengerich The Environmental Genome Project: functional analysis of polymorphisms. , 1998, Environmental health perspectives.

[13]  Samuel H. Wilson,et al.  The Environmental Genome Project: phase I and beyond. , 2004, Molecular interventions.

[14]  R. Sharp,et al.  The Environmental Genome Project and Bioethics , 1999, Kennedy Institute of Ethics journal.