Prevalence of Hyper- and Hypoglycemia Among Inpatients With Diabetes

The recent demonstration (1–3) of the benefits of intensive glycemic control in hospitalized patients has renewed interest in inpatient management of diabetes. Poor glycemic control is a marker for poor quality of hospital care (4), as well as an important safety issue: insulin is one of five medications most associated with inpatient medication errors (5,6). Moreover, many hospitals continue to solely rely on insulin “sliding scales” despite the limitations of this approach (7,8). To gain a broader understanding of the current quality of inpatient diabetes management, we analyzed the prevalence and management of hyper- and hypoglycemia among 999 patients with known diabetes treated in 44 hospitals across the U.S. Data were derived from two sources: the University Health System Consortium (UHC) Diabetes Benchmarking Project and VHA, Inc. The UHC project collected inpatient and outpatient data in 2003 by standardized chart review of 274 patients aged ≥18 years with type 1 and type 2 diabetes (diagnosed by their outpatient physicians), who were admitted as inpatients to 1 of 29 academic medical centers located in 20 states. Chart reviewers identified the highest and lowest glucose values during hospital admissions and recorded the highest and lowest glucose results for the 2 days preceding and following the peak and nadir. In 2003–2004, 15 member hospitals of VHA, Inc, an alliance that serves ∼1,400 not-for-profit U.S. hospitals, performed baseline chart reviews on 725 general medical and surgical patients aged >18 …

[1]  S. Inzucchi,et al.  Inpatient management of diabetes mellitus. , 2002, The American journal of medicine.

[2]  S. Braithwaite,et al.  Hospital hypoglycemia: not only treatment but also prevention. , 2004, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[3]  S. Crawford,et al.  Survey of hospital systems and common serious medication errors. , 1998, Journal of healthcare risk management : the journal of the American Society for Healthcare Risk Management.

[4]  M Schetz,et al.  Intensive insulin therapy in critically ill patients. , 2001, The New England journal of medicine.

[5]  J. Duncan,et al.  Efficacy of sliding-scale insulin therapy: a comparison with prospective regimens. , 1994, Family practice research journal.

[6]  H Wedel,et al.  Infarction : Long-Term Results From the Diabetes and Insulin-Glucose Infusion Conventionally Treated Patients With Diabetes Mellitus and Acute Myocardial Glycometabolic State at Admission : Important Risk Marker of Mortality in , 1999 .

[7]  Richard Segal,et al.  Identifying clinically significant preventable adverse drug events through a hospital's database of adverse drug reaction reports. , 2002, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[8]  I. Hirsch,et al.  Hospital management of diabetes. , 2005, Endocrinology and metabolism clinics of North America.

[9]  A. Garber American College of Endocrinology and American Diabetes Association consensus statement on inpatient diabetes and glycemic control. , 2006, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[10]  B. Bistrian,et al.  Intensive insulin therapy in critically ill patients. , 2002, The New England journal of medicine.

[11]  R. Zimmerman,et al.  Diabetes care in the hospital: is there clinical inertia? , 2006, Journal of hospital medicine.

[12]  R. Mcnutt,et al.  Eliminating inpatient sliding-scale insulin: a reeducation project with medical house staff. , 2005, Diabetes care.

[13]  G. Umpierrez,et al.  Glycemic chaos (not glycemic control) still the rule for inpatient care: how do we stop the insanity? , 2006, Journal of hospital medicine.

[14]  Eliminating inpatient sliding-scale insulin: a reeducation project with medical house staff. , 2005, Diabetes care.

[15]  K. Jablonski,et al.  Unrecognized Diabetes Among Hospitalized Patients , 1998, Diabetes Care.

[16]  I. Hirsch,et al.  American College of Endocrinology position statement on inpatient diabetes and metabolic control. , 2004, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[17]  K. Malmberg Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus , 1997, BMJ.

[18]  Irl B Hirsch,et al.  Management of diabetes and hyperglycemia in hospitals. , 2004, Diabetes care.

[19]  Silvio E. Inzucchi,et al.  Management of Hyperglycemia in the Hospital Setting , 2006 .

[20]  L. Poretsky,et al.  Effects of an Intervention by a Diabetes Team in Hospitalized Patients With Diabetes , 1997, Diabetes Care.

[21]  G. Grunkemeier,et al.  Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. , 2003, The Journal of thoracic and cardiovascular surgery.

[22]  Inpatient management of diabetes and hyperglycemia among general medicine patients at a large teaching hospital. , 2006, Journal of hospital medicine.

[23]  James Stephen Krinsley,et al.  Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. , 2003, Mayo Clinic proceedings.

[24]  C. Levetan,et al.  Impact of endocrine and diabetes team consultation on hospital length of stay for patients with diabetes. , 1995, The American journal of medicine.

[25]  F. Brancati,et al.  Glycemic control and sliding scale insulin use in medical inpatients with diabetes mellitus. , 1997, Archives of internal medicine.

[26]  H. Chueh,et al.  Clinical inertia in the management of Type 2 diabetes metabolic risk factors , 2004, Diabetic medicine : a journal of the British Diabetic Association.