Upper visual space neglect and motor deficits after section of the midbrain commissures in the cat

The neurological deficits following section of the midbrain commissures were studied in the cat. After a lesion of the commissures between the superior and inferior colliculi, with or without involvement of the posterior commissure, the animals showed a long lasting inattention for stimuli in the upper visual space, lack of exploratory head movements towards the neglected space, head ventroflexion and vertical paralysis of gaze. After a lesion of the commissure between the superior colliculi or of its rostral part only, the same symptomatology appeared, but it was short lasting. After a lesion of the posterior commissure, the head was kept dorsiflexed, the exploratory head movements towards the lower visual space were reduced and the stimuli presented in this space were often neglected. There was a paralysis of vertical eye movements. The findings are discussed in the frame of a premotor theory of neglect.

[1]  M. Paula-Barbosa,et al.  Auditory cortical projections to the superior colliculus in the cat. , 1973, Brain research.

[2]  E. W. Powell,et al.  Projections of the inferior colliculus in cat , 1969, The Journal of comparative neurology.

[3]  T. Powell,et al.  The projection of the auditory cortex upon the diencephalon and brain stem in the cat. , 1969, Brain research.

[4]  V. Henn,et al.  Vertical eye movement related unit activity in the rostral mesencephalic reticular formation of the alert monkey , 1977, Brain Research.

[5]  M. B. Bender,et al.  COMMENTS ON THE PHYSIOLOGY AND PATHOLOGY OF EYE MOVEMENTS IN THE VERTICAL PLANE , 1960, The Journal of nervous and mental disease.

[6]  S. Edwards.  Autoradiographic studies of the projections of the midbrain reticular formation: Descending projections of nucleus cuneiformis , 1975, The Journal of comparative neurology.

[7]  Skultety Fm.  Circus movements in cats following midbrain stimulation through chronically implanted electrodes. , 1962 .

[8]  C. Galletti,et al.  Contralateral tectal projections from single areas of the visual cortex in the cat. , 1981, Archives italiennes de biologie.

[9]  J. Büttner-Ennever,et al.  A cell group associated with vertical eye movements in the rostral mesencephalic reticular formation of the monkey , 1978, Brain Research.

[10]  M. B. Bender,et al.  The pretectal syndrome in monkeys. I. Disturbances of gaze and body posture. , 1969, Brain : a journal of neurology.

[11]  G. Rizzolatti,et al.  Deficits in attention and movement following the removal of postarcuate (area 6) and prearcuate (area 8) cortex in macaque monkeys. , 1983, Brain : a journal of neurology.

[12]  K M Heilman,et al.  Mechanisms underlying the unilateral neglect syndrome. , 1977, Advances in neurology.

[13]  P. Groves,et al.  Organization by sensory modality in the reticular formation of the rat. , 1973, Brain research.

[14]  J. Syka,et al.  Activation of superior colliculus neurons and motor responses after electrical stimulation of the inferior colliculus. , 1970, Experimental neurology.

[15]  R. Hassler.  Supranuclear structures regulating binocular eye and head movements. , 1972, Bibliotheca ophthalmologica : supplementa ad ophthalmologica.

[16]  M. Mesulam.  A cortical network for directed attention and unilateral neglect , 1981, Annals of neurology.

[17]  A. Cowey,et al.  Visual field defects after frontal eye-field lesions in monkeys. , 1971, Brain research.

[18]  A. Antonini,et al.  Indirect, across-the-midline retinotectal projections and representation of ipsilateral visual field in superior colliculus of the cat. , 1978, Journal of neurophysiology.

[19]  H. H. Magalha˜es-Castro,et al.  Horseradish peroxidase labeling of cat tectotectal cells , 1978, Brain Research.

[20]  S B Edwards,et al.  The commissural projection of the superior colliculus in the cat , 1977, The Journal of comparative neurology.

[21]  T H MEIKLE,et al.  THE ROLE OF THE SUPERIOR COLLICULUS IN VISUALLY GUIDED BEHAVIOR. , 1965, Experimental neurology.

[22]  J. Segundo,et al.  SENSORY PROPERTIES OF NEURONS IN THE MESENCEPHALIC RETICULAR FORMATION. , 1964, Journal of neurophysiology.

[23]  G. Rizzolatti.  Mechanisms of Selective Attention in Mammals , 1983 .

[24]  W. R. Hess,et al.  Motorische Funktion des Tektal- und Tegmentalgebietes; pp. 1–26 , 1946 .

[25]  C. Baleydier.  A bilateral cortical projection to the superior colliculus in the cat , 1977, Neuroscience Letters.

[26]  C. Yeo,et al.  The effects of unilateral frontal eye field lesions in the monkey: Visual-motor guidance and avoidance behaviour , 1981, Behavioural Brain Research.

[27]  R. Hill,et al.  Responsiveness to sensory stimulation of units in the superior colliculus and subjacent tectotegmental regions of the rabbit. , 1966, Experimental neurology.

[28]  J. Hyde,et al.  Brainsten-induced eye movements in cats. , 1957, The Journal of comparative neurology.

[29]  L R Harris,et al.  The superior colliculus and movements of the head and eyes in cats , 1980, The Journal of physiology.

[30]  T. Powell.  Bilateral cortico-tectal projection from the visual cortex in the cat , 1976, Nature.

[31]  J. Kaas,et al.  Visuotopic organization of the superior colliculus in normal and Siamese cats. , 1974, Brain research.

[32]  E. Spiegel,et al.  OCULAR DISTURBANCES ASSOCIATED WITH EXPERIMENTAL LESIONS OF THE MESENCEPHALIC CENTRAL GRAY MATTER: WITH SPECIAL REFERENCE TO VERTICAL OCULAR MOVEMENTS , 1937 .

[33]  G. Rizzolatti,et al.  The Role of the Superior Colliculus and Pretectum in Vision and Visually Guided Behavior , 1973 .

[34]  H. Buchtel,et al.  Successful interocular transfer of visual pattern discriminations in split-chiasm cats with section of the intertectal and posterior commissures , 1978, Physiology & Behavior.

[35]  J. Graham.  An autoradiographic study of the efferent connections of the superior colliculus in the cat , 1977, The Journal of comparative neurology.

[36]  W. Welker,et al.  ROLE OF AUDITORY CORTEX IN REFLEX HEAD ORIENTATION BY CATS TO AUDITORY STIMULI. , 1963, Journal of comparative and physiological psychology.

[37]  G. M. Gerken.  Electrical stimulation of the subcortical auditory system in behaving cat. , 1970, Brain research.