Artepillin C: A comprehensive review of its chemistry, bioavailability, and pharmacological properties.
暂无分享,去创建一个
[1] S. Tawata,et al. Chemical composition and pharmacological properties of Macaranga‐type Pacific propolis: A review , 2020, Phytotherapy research : PTR.
[2] P. H. Aoki,et al. Correlating Artepillin C cytotoxic activity on HEp-2 cells with bioinspired systems of plasma membranes. , 2020, Materials science & engineering. C, Materials for biological applications.
[3] H. Maruta,et al. Chemical evolution for taming the ‘pathogenic kinase’ PAK1 , 2020, Drug Discovery Today.
[4] H. Maruta,et al. PAK1-blockers: Potential Therapeutics against COVID-19 , 2020, Medicine in Drug Discovery.
[5] Halim Maaroufi. LxxIxE-like Motif in Spike Protein of SARS-CoV-2 that is Known to Recruit the Host PP2A-B56 Phosphatase Mimics Artepillin C, an Immunomodulator, of Brazilian Green Propolis , 2020, bioRxiv.
[6] M. Pineda,et al. A comparative study between Chinese propolis and Brazilian green propolis: metabolite profile and bioactivity. , 2020, Food & function.
[7] Xiangqian Guo,et al. Systemic analysis of the expression and prognostic significance of PAKs in breast cancer. , 2020, Genomics.
[8] R. Casoti,et al. Effect of light, oxygen and temperature on the stability of artepillin C and p-coumaric acid from Brazilian green propolis. , 2020, Journal of pharmaceutical and biomedical analysis.
[9] R. Tucker,et al. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling—Brief Report , 2019, Arteriosclerosis, thrombosis, and vascular biology.
[10] E. Martinez,et al. Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach. , 2019, Journal of ethnopharmacology.
[11] L. M. da Silva,et al. Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of Artepillin C , 2019, Inflammopharmacology.
[12] Y. Hirata,et al. Neuroprotective effects of Brazilian green propolis on oxytosis/ferroptosis in mouse hippocampal HT22 cells. , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[13] Takuya Suzuki,et al. Brazilian propolis extract reduces intestinal barrier defects and inflammation in a colitic mouse model. , 2019, Nutrition research.
[14] J. Sohng,et al. Biotechnological Advances in Resveratrol Production and its Chemical Diversity , 2019, Molecules.
[15] I. Voets,et al. Effects of artepillin C on model membranes displaying liquid immiscibility , 2019, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
[16] O. N. Oliveira,et al. Interaction of Artepillin C with model membranes: Effects of pH and ionic strength. , 2019, Biochimica et biophysica acta. Biomembranes.
[17] M. Bruschi,et al. Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines. , 2019, Anti-cancer agents in medicinal chemistry.
[18] F. A. R. Santos,et al. The presence of Fabaceae in the pollen profile of propolis produced in northeastern Brazil , 2018, Acta Botanica Brasilica.
[19] Ren Wang,et al. De Novo Biosynthesis of p-Coumaric Acid in E. coli with a trans-Cinnamic Acid 4-Hydroxylase from the Amaryllidaceae Plant Lycoris aurea , 2018, Molecules.
[20] T. Glumoff,et al. Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes , 2018, Journal of Physiology and Biochemistry.
[21] L. M. da Silva,et al. Artepillin C, drupanin, aromadendrin-4'-O-methyl-ether and kaempferide from Brazilian green propolis promote gastroprotective action by diversified mode of action. , 2018, Journal of ethnopharmacology.
[22] J. Koo,et al. Upregulation of P21-Activated Kinase 1 (PAK1)/CREB Axis in Squamous Non-Small Cell Lung Carcinoma , 2018, Cellular Physiology and Biochemistry.
[23] T. Tasca,et al. Brown propolis-metabolomic innovative approach to determine compounds capable of killing Staphylococcus aureus biofilm and Trichomonas vaginalis. , 2018, Food research international.
[24] K. Takeda,et al. A water-soluble derivative of propolis augments the cytotoxic activity of natural killer cells. , 2018, Journal of ethnopharmacology.
[25] S. Kaul,et al. Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action. , 2018, International journal of oncology.
[26] A. Ikari,et al. Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis. , 2018, Biochemical and biophysical research communications.
[27] T. Chino,et al. Artepillin C as a targeting survivin molecule in oral squamous cell carcinoma cells in vitro: A preliminary study , 2018, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
[28] J. Chung,et al. PUB072 Significance of PAK1/CREB Pathway in Lung Adenocarcinoma Oncogenesis , 2017 .
[29] G. Baldwin,et al. Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis , 2017, BMC Cancer.
[30] Q. Liao,et al. Overexpression of PAK1 Correlates with Aberrant Expression of EMT Markers and Poor Prognosis in Non-Small Cell Lung Cancer , 2017, Journal of Cancer.
[31] Xia-sen Jiang,et al. Identification of Free Radical Scavengers from Brazilian Green Propolis Using Off-Line HPLC-DPPH Assay and LC-MS. , 2017, Journal of food science.
[32] Y. Uto,et al. 1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability. , 2017, Drug discoveries & therapeutics.
[33] M. C. Marcucci,et al. Artepillin C and phenolic compounds responsible for antimicrobial and antioxidant activity of green propolis and Baccharis dracunculifolia DC , 2017, Journal of applied microbiology.
[34] I. Ferreira,et al. Hydroxycinnamic Acids and Their Derivatives: Cosmeceutical Significance, Challenges and Future Perspectives, a Review , 2017, Molecules.
[35] V. Bolzani,et al. In Vitro Metabolism of Artepillin C by Rat and Human Liver Microsomes , 2017, Planta Medica.
[36] I. Voets,et al. Interaction of Artepillin C with model membranes , 2017, European Biophysics Journal.
[37] S. Kumazawa,et al. Artepillin C, a Typical Brazilian Propolis-Derived Component, Induces Brown-Like Adipocyte Formation in C3H10T1/2 Cells, Primary Inguinal White Adipose Tissue-Derived Adipocytes, and Mice , 2016, PloS one.
[38] Samantha Serra Costa,et al. Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil , 2016, PloS one.
[39] H. Maruta,et al. Artepillin C and Other Herbal PAK1‐blockers: Effects on Hair Cell Proliferation and Related PAK1‐dependent Biological Function in Cell Culture , 2016, Phytotherapy research : PTR.
[40] S. Fischer,et al. Deletion of cyclooxygenase-2 inhibits K-ras–induced lung carcinogenesis , 2015, Oncotarget.
[41] J. Ruiz-Fuentes,et al. Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial‐mediated pathway , 2015, The Journal of pharmacy and pharmacology.
[42] F. Tamanoi,et al. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis , 2015, BMC Cancer.
[43] H. Kumura,et al. Stimulatory effect of Brazilian propolis on hair growth through proliferation of keratinocytes in mice. , 2014, Journal of agricultural and food chemistry.
[44] George Q. Li,et al. Recent Advances in the Chemical Composition of Propolis , 2014, Molecules.
[45] K. Seong,et al. PAK1 tyrosine phosphorylation is required to induce epithelial-mesenchymal transition and radioresistance in lung cancer cells. , 2014, Cancer research.
[46] Y. Akao,et al. Propolis cinnamic acid derivatives induce apoptosis through both extrinsic and intrinsic apoptosis signaling pathways and modulate of miRNA expression. , 2014, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[47] H. Yoshida,et al. In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis (AF-08) , 2014 .
[48] X. Chen,et al. A systematic review on biological activities of prenylated flavonoids , 2014, Pharmaceutical biology.
[49] D. Tavares,et al. Comparative Evaluation of Antiproliferative Effects of Brazilian Green Propolis, Its Main Source Baccharis dracunculifolia, and Their Major Constituents Artepillin C and Baccharin , 2014, Planta Medica.
[50] D. Tavares,et al. Evaluation of Genotoxicity and Antigenotoxicity of Artepillin C in V79 Cells by the Comet and Micronucleus Assays , 2013, Nutrition and cancer.
[51] H. Ashida,et al. Propolis extract promotes translocation of glucose transporter 4 and glucose uptake through both PI3K- and AMPK-dependent pathways in skeletal muscle. , 2013, BioFactors.
[52] W. Krol,et al. Inhibition of Inflammatory Response by Artepillin C in Activated RAW264.7 Macrophages , 2013, Evidence-based complementary and alternative medicine : eCAM.
[53] A. Stepan,et al. Metabolism-guided drug design , 2013 .
[54] G. C. Chan,et al. The Immunomodulatory and Anticancer Properties of Propolis , 2013, Clinical Reviews in Allergy & Immunology.
[55] T. Misaka,et al. Artepillin C, a Major Ingredient of Brazilian Propolis, Induces a Pungent Taste by Activating TRPA1 Channels , 2012, PloS one.
[56] H. Ishikawa,et al. A Pilot, Randomized, Placebo-Controlled, Double-Blind Phase 0/Biomarker Study on Effect of Artepillin C–Rich Extract of Brazilian Propolis in Frequent Colorectal Adenoma Polyp Patients , 2012, Journal of the American College of Nutrition.
[57] W. Krol,et al. Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis , 2012, International journal of oncology.
[58] F. A. Resende,et al. Comparative Studies of the (Anti) Mutagenicity of Baccharis dracunculifolia and Artepillin C by the Bacterial Reverse Mutation Test , 2012, Molecules.
[59] P. Fasinu,et al. Liver-based in vitro technologies for drug biotransformation studies - a review. , 2012, Current drug metabolism.
[60] Yong-Kun Park,et al. Comparison of Effects of the Ethanolic Extracts of Brazilian Propolis on Human Leukemic Cells As Assessed with the MTT Assay , 2011, Evidence-based complementary and alternative medicine : eCAM.
[61] H. Maruta. Effective neurofibromatosis therapeutics blocking the oncogenic kinase PAK1. , 2011, Drug discoveries & therapeutics.
[62] R. Deng,et al. Brazilian green propolis and its constituent, Artepillin C inhibits allogeneic activated human CD4 T cells expansion and activation. , 2011, Journal of ethnopharmacology.
[63] D. Tavares,et al. Antigenotoxicity of artepillin C in vivo evaluated by the micronucleus and comet assays , 2011, Journal of applied toxicology : JAT.
[64] W. Krol,et al. The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells. , 2011, International journal of oncology.
[65] N. Yamaotsu,et al. Brazilian propolis-derived components inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. , 2011, Biochimica et biophysica acta.
[66] C. Voelkel-Johnson. TRAIL-mediated signaling in prostate, bladder and renal cancer , 2011, Nature Reviews Urology.
[67] B. Cha,et al. Artepillin C, as a PPARγ ligand, enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. , 2011, Biochemical pharmacology.
[68] W. Krol,et al. Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis. , 2011, International journal of oncology.
[69] M. C. Marcucci,et al. Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines. , 2010, Memorias do Instituto Oswaldo Cruz.
[70] Hung-Yi Wu,et al. Upregulation of the Chemokine (C-C Motif) Ligand 2 via a Severe Acute Respiratory Syndrome Coronavirus Spike-ACE2 Signaling Pathway , 2010, Journal of Virology.
[71] M. Vidyavathi,et al. Role of Human Liver Microsomes in In Vitro Metabolism of Drugs—A Review , 2010, Applied biochemistry and biotechnology.
[72] Shunya Takahashi,et al. Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes. , 2010, Bioorganic & medicinal chemistry.
[73] H. Hara,et al. Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen‐glucose deprivation Stress, with a gene‐expression analysis , 2009, Phytotherapy research : PTR.
[74] Kanako Sasaki,et al. Prenylation of aromatic compounds, a key diversification of plant secondary metabolites. , 2009, Phytochemistry.
[75] S. Hsu,et al. Precipitation of sub-micron particles of 3,5-diprenyl-4-hydroxycinnamic acid in Brazilian propolis from supercritical carbon dioxide anti-solvent solutions , 2009 .
[76] H. Nagasawa,et al. Correlation between antiangiogenic activity and antioxidant activity of various components from propolis. , 2009, Molecular nutrition & food research.
[77] H. Matsushime,et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells , 2009, Proceedings of the National Academy of Sciences.
[78] Chiehming J. Chang,et al. Supercritical fluids extraction of cinnamic acid derivatives from Brazilian propolis and the effect on growth inhibition of colon cancer cells , 2009 .
[79] V. Mautner,et al. Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice , 2009, Phytotherapy research : PTR.
[80] Isaac Turner,et al. Overexpression of cyclin D1 mRNA in colorectal carcinomas and relationship to clinicopathological features: Anin situ hybridization analysis , 2009, Pathology Oncology Research.
[81] A. Vollmar,et al. Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis. , 2008, European journal of pharmacology.
[82] Y. Kano,et al. Artepillin C Derived from Propolis Induces Neurite Outgrowth in PC12m3 Cells via ERK and p38 MAPK Pathways , 2008, Neurochemical Research.
[83] K. Ohkubo,et al. Enhanced radical-scavenging activity of naturally-oriented artepillin C derivatives. , 2008, Chemical communications.
[84] H. Nagasawa,et al. Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. , 2007, Cancer letters.
[85] H. Hara,et al. Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions. , 2007, Life sciences.
[86] M. Baba,et al. Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon. , 2006, Cancer letters.
[87] H. Nagasawa,et al. Artepillin C isoprenomics: design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity. , 2006, Bioorganic & medicinal chemistry.
[88] M. Ushio-Fukai. Redox signaling in angiogenesis: role of NADPH oxidase. , 2006, Cardiovascular research.
[89] Y. Konishi,et al. Absorption and bioavailability of artepillin C in rats after oral administration. , 2005, Journal of agricultural and food chemistry.
[90] Tatsushi Yoshida,et al. Artepillin C in Brazilian propolis induces G0/G1 arrest via stimulation of Cip1/p21 expression in human colon cancer cells , 2005, Molecular carcinogenesis.
[91] K. Heidenreich,et al. Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity. , 2005, Endocrinology.
[92] Y. Konishi. Transepithelial transport of artepillin C in intestinal Caco-2 cell monolayers. , 2005, Biochimica et biophysica acta.
[93] E. Rozengurt,et al. Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. , 2005, Cancer research.
[94] Kazuma Yoshizumi,et al. [Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats]. , 2005, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
[95] G. Schmeda-Hirschmann,et al. Free radical scavengers and antioxidants from Baccharis grisebachii. , 2004, Journal of ethnopharmacology.
[96] H. Ashida,et al. Antioxidative bioavailability of artepillin C in Brazilian propolis. , 2004, Archives of biochemistry and biophysics.
[97] J. Testa,et al. A Clue to the Therapy of Neurofibromatosis Type 2: NF2/Merlin Is a PAK1 Inhibitor , 2004, Cancer journal.
[98] Á. Ravelo,et al. Constituents of the Argentinian medicinal plant Baccharis grisebachii and their antimicrobial activity. , 2003, Journal of ethnopharmacology.
[99] J. Terao,et al. Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. , 2003, Archives of biochemistry and biophysics.
[100] Y. Akao,et al. Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines. , 2003, Biological & pharmaceutical bulletin.
[101] H. Yamada,et al. Inhibitory effects of propolis granular A P C on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. , 2003, Cancer letters.
[102] K. Ohkubo,et al. Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism. , 2003, Organic & biomolecular chemistry.
[103] H. Nagasawa,et al. First total synthesis of artepillin C established by o,o'-diprenylation of p-halophenols in water. , 2002, The Journal of organic chemistry.
[104] A. Gasbarrini,et al. Severe imbalance of cell proliferation and apoptosis in the left colon and in the rectosigmoid tract in subjects with a history of large adenomas , 2001, Gut.
[105] M. Micallef,et al. Apoptosis of human leukemia cells induced by Artepillin C, an active ingredient of Brazilian propolis. , 2001, Anticancer research.
[106] S. Kadota,et al. Hepatoprotective and anti-Helicobacter pylori activities of constituents from Brazilian propolis. , 2001, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[107] M. Micallef,et al. Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C , 2001, Virchows Archiv.
[108] M. Micallef,et al. Renal carcinogenesis induced by ferric nitrilotriacetate in mice, and protection from it by Brazilian propolis and Artepillin C , 2000, Pathology international.
[109] D. Sorescu,et al. NAD(P)H oxidase: role in cardiovascular biology and disease. , 2000, Circulation research.
[110] S. Toyokuni,et al. Persistent oxidative stress in human colorectal carcinoma, but not in adenoma. , 1999, Free radical biology & medicine.
[111] S. Moss,et al. Human right and left colon differ in epithelial cell apoptosis and in expression of Bak, a pro-apoptotic Bcl-2 homologue , 1999, Gut.
[112] T. Miyase,et al. Studies on the Constituents of Brazilian Propolis. , 1998 .
[113] J. Rutkowski,et al. A role for Pak protein kinases in Schwann cell transformation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[114] M. Micallef,et al. Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis. , 1998, Cancer detection and prevention.
[115] P. L. Rosalen,et al. Antimicrobial Activity of Propolis on Oral Microorganisms , 1998, Current Microbiology.
[116] P. Grambsch,et al. Methodological findings and considerations in measuring colorectal epithelial cell proliferation in humans. , 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[117] T. Matsuno,et al. Preferential cytotoxicity to tumor cells of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C) isolated from propolis. , 1997, Anticancer research.
[118] M. Kurimoto,et al. Isolation and identification of antimicrobial compounds in Brazilian propolis , 1994 .
[119] A. Grollman,et al. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG , 1991, Nature.