Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway.

[1]  A. Thirupathi,et al.  Methotrexate normalized keratinocyte activation cycle by overturning abnormal keratins as well as deregulated inflammatory mediators in psoriatic patients. , 2015, Clinica chimica acta; international journal of clinical chemistry.

[2]  U. Sohn,et al.  SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8⁺ T cells in mice. , 2015, Cellular signalling.

[3]  Qiang Xu,et al.  Decrease of Functional Activated T and B Cells and Treatment of Glomerulonephitis in Lupus-Prone Mice Using a Natural Flavonoid Astilbin , 2015, PloS one.

[4]  J. Yeung,et al.  Interleukin-17 Antagonists in the Treatment of Psoriasis , 2015, Journal of cutaneous medicine and surgery.

[5]  Weizhen Zhang,et al.  Ghrelin Inhibits the Differentiation of T Helper 17 Cells through mTOR/STAT3 Signaling Pathway , 2015, PloS one.

[6]  Sarah L. Gaffen,et al.  The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing , 2014, Nature Reviews Immunology.

[7]  Thomas T. Y. Wang,et al.  Utility of hesperidinase for food function research: enzymatic digestion of botanical extracts alters cellular antioxidant capacities and anti-inflammatory properties. , 2014, Journal of agricultural and food chemistry.

[8]  Y. Poulin,et al.  Interleukin 17A: toward a new understanding of psoriasis pathogenesis. , 2014, Journal of the American Academy of Dermatology.

[9]  Tian-yu Chen,et al.  Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis , 2014, Molecular medicine reports.

[10]  Yanbing Ding,et al.  Induction of TGF-β and IL-10 production in dendritic cells using astilbin to inhibit dextran sulfate sodium-induced colitis. , 2014, Biochemical and biophysical research communications.

[11]  Mayte Suárez-Fariñas,et al.  Immunology of psoriasis. , 2014, Annual review of immunology.

[12]  Boyan Gao,et al.  Identification and quantification of phytochemical composition and anti-inflammatory, cellular antioxidant, and radical scavenging activities of 12 Plantago species. , 2013, Journal of agricultural and food chemistry.

[13]  C. Johansen,et al.  Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3‐Ser727 phosphorylation as a modulator of transcriptional activity , 2013, Experimental dermatology.

[14]  J. Harder,et al.  IL-17A and IFN-γ Synergistically Induce RNase 7 Expression via STAT3 in Primary Keratinocytes , 2013, PloS one.

[15]  Jinhua Xu,et al.  Transcriptional regulatory network for psoriasis , 2013, The Journal of dermatology.

[16]  W. Kong,et al.  Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro , 2012, PPAR research.

[17]  K. Vafeiadou,et al.  Neuroinflammation: modulation by flavonoids and mechanisms of action. , 2012, Molecular aspects of medicine.

[18]  L. Yu,et al.  Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana and their potential anti-inflammatory properties. , 2011, Journal of agricultural and food chemistry.

[19]  Xiao-yun Shen,et al.  Astilbin suppresses acute heart allograft rejection by inhibiting maturation and function of dendritic cells in mice. , 2010, Transplantation proceedings.

[20]  Frank O. Nestle,et al.  Mechanisms of Disease: Psoriasis. , 2009 .

[21]  Gui-Sheng Li1 *,et al.  Effect of Astilbin on Experimental Diabetic Nephropathy in vivo and in vitro , 2009, Planta medica.

[22]  L. Boon,et al.  Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis1 , 2009, The Journal of Immunology.

[23]  Graham M Lord,et al.  The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease , 2007, Clinical and experimental immunology.

[24]  A. Gottlieb,et al.  TNF Inhibition Rapidly Down-Regulates Multiple Proinflammatory Pathways in Psoriasis Plaques1 , 2005, The Journal of Immunology.

[25]  Qiang Xu,et al.  Astilbin suppresses delayed‐type hypersensitivity by inhibiting lymphocyte migration , 2003, The Journal of pharmacy and pharmacology.

[26]  Y. Cai,et al.  Astilbin suppresses collagen-induced arthritis via the dysfunction of lymphocytes , 2003, Inflammation Research.

[27]  Mark Lebwohl,et al.  Psoriasis , 1906, The Lancet.

[28]  Jennifer E Towne,et al.  The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings. , 2013, The Journal of investigative dermatology.