Speciation genes.

Until recently, the genes that cause reproductive isolation remained black boxes. Consequently, evolutionary biologists were unable to answer several questions about the identities and characteristics of "speciation genes". Over the past few years, however, evolutionary geneticists have finally succeeded in isolating several such genes, providing our first glimpse at factors that are thought to be representative of those underlying the origin of species. Evolutionary analysis of these genes suggests that speciation results from positive Darwinian selection within species. Molecular evolutionary study of the genes causing reproductive isolation may represent an important new phase in the study of speciation.

[1]  N. Daigle,et al.  An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells , 2001, The Journal of cell biology.

[2]  D. Hartl,et al.  Anomalies in the expression profile of interspecific hybrids of Drosophila melanogaster and Drosophila simulans. , 2004, Genome research.

[3]  Chung-I Wu,et al.  Genetic complexity underlying hybrid male sterility in Drosophila. , 2004, Genetics.

[4]  M. Schartl,et al.  Evolutionary origin and molecular biology of the melanoma-inducing oncogene of Xiphophorus. , 1994, Pigment cell research.

[5]  B. Charlesworth,et al.  Location of an X-linked factor causing sterility in male hybrids of Drosophila simulans and D. mauritiana , 1986, Heredity.

[6]  Chung-I Wu,et al.  Haldane's rule and its legacy: Why are there so many sterile males? , 1996, Trends in ecology & evolution.

[7]  M. Noor,et al.  Little qualitative RNA misexpression in sterile male F1 hybrids of Drosophila pseudoobscura and D. persimilis , 2002, BMC Evolutionary Biology.

[8]  Chung-I Wu,et al.  Further characterization of the Odysseus locus of hybrid sterility in Drosophila: one gene is not enough. , 1995, Genetics.

[9]  J. True,et al.  A genome-wide survey of hybrid incompatibility factors by the introgression of marked segments of Drosophila mauritiana chromosomes into Drosophila simulans. , 1996, Genetics.

[10]  Chung-I Wu,et al.  A rapidly evolving homeobox at the site of a hybrid sterility gene. , 1998, Science.

[11]  D. Presgraves,et al.  A fine-scale genetic analysis of hybrid incompatibilities in Drosophila. , 2003, Genetics.

[12]  Pawel Michalak,et al.  Genome-wide patterns of expression in Drosophila pure species and hybrid males. , 2003, Molecular biology and evolution.

[13]  H. A. Orr,et al.  The population genetics of speciation: the evolution of hybrid incompatibilities. , 1995, Genetics.

[14]  L. Hurst,et al.  Causes of sex ratio bias may account for unisexual sterility in hybrids: a new explanation of Haldane's rule and related phenomena. , 1991, Genetics.

[15]  J. Parsch,et al.  Molecular evolution of sex-biased genes in Drosophila. , 2004, Molecular biology and evolution.

[16]  D. Hartl,et al.  Sex-ratio segregation distortion associated with reproductive isolation in Drosophila , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[17]  M. Sasa,et al.  PATTERNS OF POSTZYGOTIC ISOLATION IN FROGS , 1998, Evolution; international journal of organic evolution.

[18]  Ueli Aebi,et al.  Structure and Assembly of the Nup84p Complex , 2000, The Journal of cell biology.

[19]  S. Frank.  DIVERGENCE OF MEIOTIC DRIVE‐SUPPRESSION SYSTEMS AS AN EXPLANATION FOR SEX‐BIASED HYBRID STERILITY AND INVIABILITY , 1991, Evolution; international journal of organic evolution.

[20]  SEXUAL ISOLATION EVOLVES FASTER THAN HYBRID INVIABILITY IN A DIVERSE AND SEXUALLY DIMORPHIC GENUS OF FISH (PERCIDAE: ETHEOSTOMA) , 2003, Evolution; international journal of organic evolution.

[21]  T. Price,et al.  THE EVOLUTION OF F1 POSTZYGOTIC INCOMPATIBILITIES IN BIRDS , 2002, Evolution; international journal of organic evolution.

[22]  M. Schartl,et al.  Tumor suppression in Xiphophorus by an accidentally acquired promoter. , 1993, Science.

[23]  P. Awadalla,et al.  Functional Divergence Caused by Ancient Positive Selection of a Drosophila Hybrid Incompatibility Locus , 2004, PLoS biology.

[24]  T. Dobzhansky.  Genetics and the Origin of Species , 1937 .

[25]  M. Schartl,et al.  Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus , 1989, Nature.

[26]  L. Silver,et al.  An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers , 2000, Mammalian Genome.

[27]  M. Schartl,et al.  Melanoma formation in xiphophorus: A model system for the role of receptor tyrosine kinases in tumorigenesis , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[28]  D. Barbash,et al.  A rapidly evolving MYB-related protein causes species isolation in Drosophila , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. Ashburner,et al.  The Drosophila melanogaster hybrid male rescue gene causes inviability in male and female species hybrids. , 2000, Genetics.

[30]  H. A. Orr,et al.  Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila , 2003, Nature.

[31]  PATTERNS OF POSTZYGOTIC ISOLATION IN LEPIDOPTERA , 2002, Evolution; international journal of organic evolution.

[32]  C. Wu,et al.  The genetics of reproductive isolation in the Drosophila simulans clade: X vs. autosomal effects and male vs. female effects. , 1996, Genetics.

[33]  C. Wu,et al.  Genetic analysis of speciation by means of introgression into Drosophila melanogaster. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[34]  M. Schartl,et al.  The macromelanophore locus and the melanoma oncogene Xmrk are separate genetic entities in the genome of Xiphophorus. , 1998, Genetics.

[35]  Andrew W. Davis.  Evolution of Postmating Reproductive Isolation: The Composite Nature of Haldane's Rule and Its Genetic Bases , 1993, The American Naturalist.

[36]  D. Hartl,et al.  Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. II. Mapping hybrid male sterility loci on the third chromosome. , 2003, Genetics.

[37]  D. Hartl,et al.  GENETIC DISSECTION OF HYBRID INCOMPATIBILITIES BETWEEN DROSOPHILA SIMULANS AND D. MAURITIANA.: III. HETEROGENEOUS ACCUMULATION OF HYBRID INCOMPATIBILITIES, DEGREE OF DOMINANCE, AND IMPLICATIONS FOR HALDANE—RULE , 2003, Evolution; international journal of organic evolution.

[38]  Colin D. Meiklejohn,et al.  Sex-Dependent Gene Expression and Evolution of the Drosophila Transcriptome , 2003, Science.

[39]  H. A. Orr,et al.  Genetic analysis of the hybrid male rescue locus of Drosophila. , 2000, Genetics.

[40]  M. Ashburner,et al.  A novel system of fertility rescue in Drosophila hybrids reveals a link between hybrid lethality and female sterility. , 2003, Genetics.

[41]  H. A. Orr,et al.  PATTERNS OF SPECIATION IN DROSOPHILA , 1989, Evolution; international journal of organic evolution.

[42]  Chau-Ti Ting,et al.  Genes and speciation , 2001, Nature Reviews Genetics.

[43]  P. Tiffin,et al.  PATTERNS OF REPRODUCTIVE ISOLATION IN THREE ANGIOSPERM GENERA , 2004, Evolution; international journal of organic evolution.

[44]  Lauren M McIntyre,et al.  Common pattern of evolution of gene expression level and protein sequence in Drosophila. , 2004, Molecular biology and evolution.

[45]  M. Noor,et al.  Association of Misexpression with Sterility in Hybrids of Drosophila simulansand D. mauritiana , 2004, Journal of Molecular Evolution.

[46]  S. Henikoff,et al.  The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA , 2001, Science.

[47]  E. Griffis,et al.  Distinct functional domains within nucleoporins Nup153 and Nup98 mediate transcription-dependent mobility. , 2004, Molecular biology of the cell.

[48]  W. Swanson,et al.  The rapid evolution of reproductive proteins , 2002, Nature Reviews Genetics.

[49]  H. Orr.  Mapping and characterization of a 'speciation gene' in Drosophila. , 1992, Genetical research.

[50]  S. J. Arnold,et al.  Correspondence between sexual isolation and allozyme differentiation: a test in the salamander Desmognathus ochrophaeus. , 1990, Proceedings of the National Academy of Sciences of the United States of America.