Ultrastructure of the Human Atrioventricular Node

Ultrastructure of the A-V node was studied in two human hearts. Fine details of intranodal cellular organization were then resynthesized on the basis of light microscopic examinations of over 250 human hearts. There are four different types of cells and no anatomic syncytium in the human A-V node: (1) a simple rounded cell identical to P cells of the sinus node, (2) a slender transitional cell which is by far the most numerous type in the A-V node, (3) Purkinie cells, and (4) ordinary working myocardium; both of the latter are almost exclusively at the nodal margins. The possible significance of these ultrastructural features relative to certain functions of the A-V node, such as pacemaking and delay of conduction, is discussed.

[1]  T. N. James,et al.  Anatomy of the sinus node, AV node and os cordis of the beef heart , 1965, The Anatomical record.

[2]  T. N. James,et al.  Comparative Ultrastructure of the Sinus Node in Man and Dog , 1966, Circulation.

[3]  E. Benson,et al.  ON THE STRUCTURAL CONTINUITIES OF THE TRANSVERSE TUBULAR SYSTEM OF RABBIT AND HUMAN MYOCARDIAL CELLS , 1963, The Journal of cell biology.

[4]  L. Horan,et al.  Study of Ventricular Response in Atrial Fibrillation , 1961, Circulation research.

[5]  C. Brooks,et al.  Physiology of Atrioventricular Transmission , 1961, Circulation.

[6]  R. Hibbs,et al.  Electron microscopy of post‐mortem changes in the rat myocardium , 1963, The Anatomical record.

[7]  T. N. James,et al.  A new look at some old questions in clinical electrocardiography. , 1966, Henry Ford Hospital medical journal.

[8]  E. Moore,et al.  Functional Properties of the Atrioventricular Conduction System , 1963, Circulation research.

[9]  N. Soderstrom.  What is the reason for the ventricular arrhythmia in cases of auricular fibrillation? , 1950, American heart journal.

[10]  K. Kawamura.  Electron microscope studies on the cardiac conduction system of the dog. II. The sinoatrial and atrioventricular nodes. , 1961, Japanese circulation journal.

[11]  T. N. James,et al.  Anatomy of the A–V node of the dog , 1964, The Anatomical record.

[12]  D. Fawcett,et al.  FINE STRUCTURE OF TURTLE ATRIUM ratus , and three Pseudomys elegans , 2003 .

[13]  T. N. James,et al.  THE CONNECTING PATHWAYS BETWEEN THE SINUS NODE AND A-V NODE AND BETWEEN THE RIGHT AND THE LEFT ATRIUM IN THE HUMAN HEART. , 1963, American heart journal.

[14]  F. O. Simpson,et al.  THE FINE STRUCTURE OF SHEEP MYOCARDIAL CELLS; SARCOLEMMAL INVAGINATIONS AND THE TRANSVERSE TUBULAR SYSTEM , 1962, The Journal of cell biology.

[15]  T. N. James,et al.  Morphology of the human atrioventricular node, with remarks pertinent to its electrophysiology. , 1961, American heart journal.

[16]  T. N. James,et al.  Anatomy of the Cardiac Conduction System in the Rabbit , 1967, Circulation research.

[17]  D. Fawcett,et al.  The Sarcoplasmic Reticulum of Skeletal and Cardiac Muscle , 1961, Circulation.

[18]  B. Hoffman,et al.  Electrical Activity of Single Fibers of the Atrioventricular Node , 1959, Circulation research.

[19]  H. Torii.  Electron Microscope Observations of the S.A and A.V Nodes and Purkinje Fibers of the Rabbit , 1962 .

[20]  R C Truex,et al.  Reconstruction of the human atrioventricular node , 1967, The Anatomical record.

[21]  D. Rayns,et al.  Transverse Tubule Apertures in Mammalian Myocardial Cells: Surface Array , 1967, Science.

[22]  D. Fawcett.  Physiologically Significant Specializations of the Cell Surface , 1962, Circulation.

[23]  L. Barr,et al.  Propagation of Action Potentials and the Structure of the Nexus in Cardiac Muscle , 1965, The Journal of general physiology.

[24]  K. Hayashi.  An electron microscope study on the conduction system of the cow heart. , 1962, Japanese circulation journal.