Chapter 33 – Toxicometabolomics: Technology and Applications

[1]  A. D’Alessandro,et al.  A mass spectrometry-based targeted metabolomics strategy of human blastocoele fluid: a promising tool in fertility research. , 2012, Molecular bioSystems.

[2]  Richard D. Smith.  Mass spectrometry in biomarker applications: from untargeted discovery to targeted verification, and implications for platform convergence and clinical application. , 2012, Clinical chemistry.

[3]  P. Bruheim,et al.  Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders. , 2012, Journal of chromatography. A.

[4]  Vladimir N. Uversky,et al.  Analyzing and Mapping Sweat Metabolomics by High-Resolution NMR Spectroscopy , 2011, PloS one.

[5]  M. Sarwal,et al.  Recent advances in biomarker discovery in solid organ transplant by proteomics , 2011, Expert review of proteomics.

[6]  Deborah I. Bunin,et al.  Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[7]  M. Hsu,et al.  Liquid chromatography-tandem mass spectrometry screening method for the simultaneous detection of stimulants and diuretics in urine. , 2011, Journal of analytical toxicology.

[8]  C. Enke.  Analytical Chemistry, a great success despite the unfortunate divisions in academic departments. , 2011, Talanta.

[9]  R. Murray.  Innovation in analytical chemistry. , 2011, Analytical Chemistry.

[10]  M. V. Heiden,et al.  Targeting cancer metabolism: a therapeutic window opens , 2011, Nature Reviews Drug Discovery.

[11]  C. Gieger,et al.  Human metabolic individuality in biomedical and pharmaceutical research , 2011, Nature.

[12]  Lining Guo,et al.  Metabolomics Reveals Elevated Macromolecular Degradation in Periodontal Disease , 2011, Journal of dental research.

[13]  Mark Wirth,et al.  Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: investigation of nicotinic acid receptor agonists. , 2011, Toxicology and applied pharmacology.

[14]  P. Murray.  Diagnosis of kidney damage using novel acute kidney injury biomarkers: assessment of kidney function alone is insufficient , 2011, Critical care.

[15]  M. Latterich,et al.  Streamlining biomarker discovery , 2011, Nature Biotechnology.

[16]  E. Castillero,et al.  Fenofibrate, a PPAR{alpha} agonist, decreases atrogenes and myostatin expression and improves arthritis-induced skeletal muscle atrophy. , 2011, American journal of physiology. Endocrinology and metabolism.

[17]  Ruth M. Pfeiffer,et al.  The impact of sample storage time on estimates of association in biomarker discovery studies , 2011, Journal of Clinical Bioinformatics.

[18]  Donald G Robertson,et al.  Metabolomics in toxicology: preclinical and clinical applications. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[19]  B. McManus,et al.  The Human Serum Metabolome , 2011, PloS one.

[20]  Kazuki Saito,et al.  Metabolomic approaches toward understanding nitrogen metabolism in plants. , 2011, Journal of experimental botany.

[21]  Christin Christin,et al.  Data processing pipelines for comprehensive profiling of proteomics samples by label-free LC-MS for biomarker discovery. , 2011, Talanta.

[22]  Yang Xia,et al.  Detrimental effects of adenosine signaling in sickle cell disease , 2011, Nature Medicine.

[23]  Zhihong Xie,et al.  A quantitative real-time RT-PCR assay for mature C. albicans biofilms , 2011, BMC Microbiology.

[24]  Christian Gieger,et al.  Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting , 2010, PloS one.

[25]  Anne M. Evans,et al.  Organization of GC/MS and LC/MS metabolomics data into chemical libraries , 2010, J. Cheminformatics.

[26]  G. Hwang,et al.  Toxicometabolomics of Urinary Biomarkers for Human Gastric Cancer in a Mouse Model , 2010, Journal of toxicology and environmental health. Part A.

[27]  Jacob E. Wulff,et al.  Assessment of the effects of dentifrice on periodontal disease biomarkers in gingival crevicular fluid. , 2010, Journal of periodontology.

[28]  Lining Guo,et al.  Metabolomic Profiling Reveals Biochemical Pathways and Biomarkers Associated with Pathogenesis in Cystic Fibrosis Cells , 2010, The Journal of Biological Chemistry.

[29]  M. Hirai,et al.  Widely targeted metabolomics and coexpression analysis as tools to identify genes involved in the side-chain elongation steps of aliphatic glucosinolate biosynthesis , 2010, Amino Acids.

[30]  Osamu Okazaki,et al.  Ethylene Glycol Monomethyl Ether–Induced Toxicity Is Mediated through the Inhibition of Flavoprotein Dehydrogenase Enzyme Family , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[31]  I. Kapetanovic,et al.  Assessment of oral toxicity and safety of pentamethylchromanol (PMCol), a potential chemopreventative agent, in rats and dogs. , 2010, Toxicology.

[32]  Joseph V Bonventre,et al.  Next-generation biomarkers for detecting kidney toxicity , 2010, Nature Biotechnology.

[33]  D. J. Rose,et al.  Metabolomics for early detection of drug-induced kidney injury: review of the current status. , 2009, Bioanalysis.

[34]  I. Kapetanovic,et al.  In‐vitro and in‐vivo metabolic studies of the candidate chemopreventative pentamethylchromanol using liquid chromatography/tandem mass spectrometry , 2009 .

[35]  Stanley L Hazen,et al.  Targeted Metabolomic Evaluation of Arginine Methylation and Cardiovascular Risks: Potential Mechanisms Beyond Nitric Oxide Synthase Inhibition , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[36]  Corey D. DeHaven,et al.  Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. , 2009, Analytical chemistry.

[37]  Lining Guo,et al.  Untargeted Metabolomic Profiling as an Evaluative Tool of Fenofibrate-Induced Toxicology in Fischer 344 Male Rats , 2009, Toxicologic pathology.

[38]  Thomas Hankemeier,et al.  Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics , 2009, Metabolomics.

[39]  John T. Wei,et al.  Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression , 2009, Nature.

[40]  Suryanarayana V Vulimiri,et al.  Effects of mainstream cigarette smoke on the global metabolome of human lung epithelial cells. , 2009, Chemical research in toxicology.

[41]  J. German,et al.  Assessing individual metabolic responsiveness to a lipid challenge using a targeted metabolomic approach , 2008, Metabolomics.

[42]  C. Napoli,et al.  New insights into cardiovascular and lipid metabolomics , 2008, Journal of cellular biochemistry.

[43]  Nathan Blow,et al.  Metabolomics: Biochemistry's new look , 2008, Nature.

[44]  Xueying Zhao,et al.  PPAR-Alpha Agonist Fenofibrate Induces Renal CYP Enzymes and Reduces Blood Pressure and Glomerular Hypertrophy in Zucker Diabetic Fatty Rats , 2008, American Journal of Nephrology.

[45]  T. Ebbels,et al.  Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts , 2007, Nature Protocols.

[46]  Ying Zhang,et al.  HMDB: the Human Metabolome Database , 2007, Nucleic Acids Res..

[47]  Ram Sasisekharan,et al.  The sweet side of biomarker discovery , 2006, Nature Biotechnology.

[48]  L. Mueller,et al.  Metabolomic analysis using optimized NMR and statistical methods. , 2006, Analytical biochemistry.

[49]  Götz Schlotterbeck,et al.  Metabolite projection analysis for fast identification of metabolites in metabonomics. Application in an amiodarone study. , 2006, Analytical chemistry.

[50]  Elaine Holmes,et al.  The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements. , 2005, Pharmacogenomics.

[51]  S. Watkins,et al.  Focused metabolomic profiling in the drug development process: advances from lipid profiling. , 2005, Current opinion in chemical biology.

[52]  Yves Gibon,et al.  GMD@CSB.DB: the Golm Metabolome Database , 2005, Bioinform..

[53]  Henrik Antti,et al.  Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project. , 2003, Toxicology and applied pharmacology.

[54]  Elaine Holmes,et al.  Metabolomic analysis of the consequences of cadmium exposure in Silene cucubalus cell cultures via 1H NMR spectroscopy and chemometrics. , 2003, Phytochemistry.

[55]  Beatrice A Kallungal,et al.  Clinical considerations in study designs that use cotinine as a biomarker , 2003, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[56]  Gavin H. Thomas.  Metabolomics breaks the silence , 2001 .

[57]  J. Lindon,et al.  'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.

[58]  J. Shepherd.  The fibrates in clinical practice: focus on micronised fenofibrate. , 1994, Atherosclerosis.

[59]  D. Morgan,et al.  LABORATORY TEST FOR KIDNEY FUNCTION—UREA OR CREATININE , 1979, The Lancet.

[60]  O. Warburg.  ANNUAL REVIEW OF BIOCHEMISTRY. PREFATORY CHAPTER. , 1964, Annual review of biochemistry.