Title : Genetic and phenotypic diversity in breast tumor metastases

Authors’ Affiliations: Departments of Medical Oncology and Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA; Department of Medical Oncology, Hospital Clinic, Institut d’Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain; Department of Pathology, MizMedi Hospital, Seoul, South Korea, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Departments of Physics and Biology and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, Netherlands; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.

[1]  M. Gönen,et al.  Evolutionary pathways in BRCA1-associated breast tumors. , 2012, Cancer discovery.

[2]  S. Calderwood,et al.  Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers , 2012, Breast Cancer Research.

[3]  K. Pantel,et al.  Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ , 2011, International journal of cancer.

[4]  A. Oudenaarden,et al.  Single-molecule transcript counting of stem-cell markers in the mouse intestine , 2011, Nature Cell Biology.

[5]  Robert B. Jenkins,et al.  MYC Gene Amplification is Often Acquired in Lethal Distant Breast Cancer Metastases of Unamplified Primary Tumors , 2011, Modern Pathology.

[6]  M. Nowak,et al.  Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer , 2010, Nature.

[7]  Xiaohong Li,et al.  A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma , 2010, Cancer Prevention Research.

[8]  Anthony Rhodes,et al.  American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. , 2010, Archives of pathology & laboratory medicine.

[9]  A. Ashworth,et al.  Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas , 2010, The Journal of pathology.

[10]  M. Gönen,et al.  Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. , 2010, The Journal of clinical investigation.

[11]  Kornelia Polyak,et al.  Heterogeneity for Stem Cell–Related Markers According to Tumor Subtype and Histologic Stage in Breast Cancer , 2010, Clinical Cancer Research.

[12]  Ryan D. Morin,et al.  Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution , 2009, Nature.

[13]  Jun Luo,et al.  Copy Number Analysis Indicates Monoclonal Origin of Lethal Metastatic Prostate Cancer , 2009, Nature Medicine.

[14]  R. Weinberg,et al.  Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits , 2009, Nature Reviews Cancer.

[15]  C. Klein,et al.  Parallel progression of primary tumours and metastases , 2009, Nature Reviews Cancer.

[16]  Jun Yao,et al.  Epigenetic patterns of embryonic and adult stem cells , 2009, Cell cycle.

[17]  Å. Borg,et al.  Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer , 2008, Breast Cancer Research.

[18]  Angel Porgador,et al.  Cell type-specific DNA methylation patterns in the human breast , 2008, Proceedings of the National Academy of Sciences.

[19]  M. Ringnér,et al.  The CD44+/CD24- phenotype is enriched in basal-like breast tumors , 2008, Breast Cancer Research.

[20]  Susan G Hilsenbeck,et al.  Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. , 2008, Journal of the National Cancer Institute.

[21]  J. Andersen,et al.  Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases , 2007, Breast Cancer Research and Treatment.

[22]  R. Beroukhim,et al.  Molecular definition of breast tumor heterogeneity. , 2007, Cancer cell.

[23]  G. Sherlock,et al.  The prognostic role of a gene signature from tumorigenic breast-cancer cells. , 2007, The New England journal of medicine.

[24]  Larry Norton,et al.  Is cancer a disease of self-seeding? , 2006, Nature Medicine.

[25]  M. Fehr,et al.  Frequency and distribution pattern of distant metastases in breast cancer patients at the time of primary presentation , 2003, Archives of Gynecology and Obstetrics.

[26]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[27]  R. Tibshirani,et al.  Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[28]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[29]  A. Hirschman.  National Power and the Structure of Foreign Trade , 2024 .

[30]  M. Kenward,et al.  An Introduction to the Bootstrap , 2007 .

[31]  A. Solow,et al.  Measuring biological diversity , 2006, Environmental and Ecological Statistics.

[32]  Sang Joon Kim,et al.  A Mathematical Theory of Communication , 2006 .

[33]  W. Bossert,et al.  The Measurement of Diversity , 2001 .