I 2013, after the release of our first impact factor (IF) in June, the manuscript submission rate to ACS Catalysis doubled, remaining at the elevated rate for the remainder of the year and climbing even higher in 2014. With this increase in submissions came a concomitant increase in the standards for acceptance, both with regard to scientific and technical quality, as well as potential for impact in the field of catalysis. Thus, while manuscript submission numbers continue to rise, acceptance rates are falling, with many papers returned immediately after an initial assessment by the editor(s), and many others declined after external peer review. Anticipating another increase in submissions this summer after the release of our second IF (7.572), we expect acceptance rates to drop even further. To this end, we summarize here some recommendations that can increase the probability of having a manuscript selected for external review and, eventually, recommended for publication in ACS Catalysis. Several measures of a successful paper are that it is widely read, inspires others, and then serves as the basis for follow-up work, where it is often cited. Consequently, there are a number of factors that are important to publication in ACS Catalysis that simultaneously will help the published work become more broadly appreciated in the catalysis community. Several of these are described below. The first key question is how reliable or reproducible are the results? As Jillian Buriak, Editor-in-Chief of our sister journal, Chemistry of Materials, pointed out in a recent editorial, “irreproducible results lead to frustration, wasted resources (time, funds, materials) and questions from your peers regarding the quality of your work.” Many researchers will assess whether the results described in a paper they are reading are reliable on the basis of the way the work is presented, deciding quickly whether the work is sound enough to merit follow-up work. In this regard, there are several factors that often serve as the basis for such judgments and are important to both the trustworthiness of the results and their interpretation, as well as to successful publication in ACS Catalysis.