Advances in supercritical carbon dioxide technologies

The high price of organic solvents, environmental factors and the requirements of, for instance, the medical and food industries for ultrapure products have increased the need to develop new processing techniques. Since the end of the 1970s, supercritical fluid extraction has been used to isolate natural products, but for a long time the applications concentrated on only few products. Now the development of processes and equipment that has lasted for over three decades is beginning to pay off and industries are getting more and more interested in supercritical techniques. This article summarizes some of the advances and the latest developments in the field of supercritical fluid technology focusing on using supercritical carbon dioxide in food, nutraceutical and pharmaceutical applications and takes a quick outlook for the future prospects.

[1]  J. Hannay,et al.  I. On the solubility of solids in gases , 1880, Proceedings of the Royal Society of London.

[2]  Michel Perrut,et al.  Supercritical Fluid Applications: Industrial Developments and Economic Issues , 2000 .

[3]  K. Bartle,et al.  Preparative-scale supercritical fluid chromatography , 1995 .

[4]  T. L. Chester,et al.  Supercritical fluid chromatography and extraction. , 1992, Analytical chemistry.

[5]  B. Subramaniam,et al.  Pharmaceutical processing with supercritical carbon dioxide. , 1997, Journal of pharmaceutical sciences.

[6]  P. Jessop,et al.  Homogeneous catalysis in supercritical fluids. , 1999, Science.

[7]  Miguel Valcárcel,et al.  Analytical Supercritical Fluid Extraction , 1994 .

[8]  Jean W. Tom,et al.  Preparation of Microparticulates Using Supercritical Fluids , 1996 .

[9]  Tony Clifford,et al.  Fundamentals of Supercritical Fluids , 1999 .

[10]  B. Müller,et al.  Aerosol solvent extraction system : a new microparticle production technique , 1993 .

[11]  A. Berthod,et al.  SEPARATION OF STEROIDS BY COUNTERCURRENT CHROMATOGRAPHY USING SUPERCRITICAL FLUID CARBON DIOXIDE , 1999 .

[12]  E. Reverchon SUPERCRITICAL ANTISOLVENT PRECIPITATION OF MICRO- AND NANO-PARTICLES , 1999 .

[13]  I. Sanchez,et al.  Semicrystalline microfibrils and hollow fibres by precipitation with a compressed-fluid antisolvent , 1995 .

[14]  P. Debenedetti,et al.  Supercritical antisolvent process for substituted para-linked aromatic polyamides: phase equilibrium and morphology study , 1993 .

[15]  A. Randolph,et al.  Separation of β‐Carotene Mixtures Precipitated from Liquid Solvents with High‐Pressure CO2 , 1991 .

[16]  G. Brunner,et al.  Fractionation of fatty acid ethyl esters by supercritical CO2: high separation efficiency using an automated countercurrent column , 1998 .

[17]  M. Türk Formation of small organic particles by RESS: experimental and theoretical investigations , 1999 .