Structure and chromosome mapping of the human SIX4 and murine Six4 genes

Six4, a member of the homeobox gene subfamily (Six), is expressed in a developmentally regulated fashion, and supposed to be involved in embryogenesis. We cloned the human SIX4 and murine Six4 genomic DNAs and determined their structures. The structure, including the 5′ upstream region of both genes, was well conserved suggesting the conserved function and regulation of these genes. Human SIX4 was mapped to chromosome 14q23.

[1]  P. Bovolenta,et al.  Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies. , 1999, Genomics.

[2]  J. Concordet,et al.  Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[3]  J. Toy,et al.  The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[4]  T. Saito,et al.  Tissue and developmental distribution of Six family gene products. , 1998, The International journal of developmental biology.

[5]  N. Shimizu,et al.  Isolation and characterization of the plasma hyaluronan-binding protein (PHBP) gene (HABP2). , 1997, Journal of biochemistry.

[6]  N. Shimizu,et al.  Human BAC library: construction and rapid screening. , 1997, Gene.

[7]  T. Takizawa,et al.  Identification and expression of six family genes in mouse retina , 1996, FEBS letters.

[8]  M. Siciliano,et al.  Cloning of the human SIX1 gene and its assignment to chromosome 14. , 1996, Genomics.

[9]  N. Copeland,et al.  Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. , 1995, Development.

[10]  M. Siciliano,et al.  A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat. , 1995, Human molecular genetics.

[11]  V. Hartenstein,et al.  Homeobox genes and connective tissue patterning. , 1995, Development.

[12]  G Thiene,et al.  The gene for arrhythmogenic right ventricular cardiomyopathy maps to chromosome 14q23-q24. , 1994, Human molecular genetics.

[13]  V. Hartenstein,et al.  The drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system , 1994, Neuron.

[14]  E. Maltby,et al.  A case of deletion 14(q22.1-->q22.3) associated with anophthalmia and pituitary abnormalities. , 1993, Journal of medical genetics.

[15]  D. Betts,et al.  Deletion 14q (q22q23) associated with anophthalmia, absent pituitary, and other abnormalities. , 1991, Journal of Medical Genetics.

[16]  P. Bovolenta,et al.  Genomic cloning, structure, expression pattern, and chromosomal location of the human SIX3 gene. , 1999, Genomics.

[17]  Keiko Ikeda,et al.  Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. , 1996, Nucleic acids research.