Adult Consequences of Fetal Growth Restriction

Low birthweight in relation to the length of gestation, is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and type 2 diabetes. These associations extend across the whole range of birthweight, which implies that normal variations in nutrient delivery to the fetus have profound long-term effects. The associations are thought to reflect the body's plasticity during development, by which its structure and function can be permanently changed by the intra uterine and early post natal environment. Slow growth during infancy and rapid weight gain after the age of two years exacerbate the effect of slow fetal growth. Cardiovascular disease and type 2 diabetes arise through a series of interactions between environmental influences and the pathways of development that precede them.

[1]  C Osmond,et al.  Mother's weight in pregnancy and coronary heart disease in a cohort of finnish men: follow up study , 1997, BMJ.

[2]  P. Taylor,et al.  The Fetal Origins of Osteoporotic Fracture , 2002, Calcified Tissue International.

[3]  N. Hollenberg,et al.  Nephron number in patients with primary hypertension. , 2003, Current hypertension reports.

[4]  D. Lackland,et al.  Associations Between Birth Weight and Antihypertensive Medication in Black and White Medicaid Recipients , 2002, Hypertension.

[5]  J. Manson,et al.  Birth weight and adult hypertension and obesity in women. , 1996, Circulation.

[6]  P. Gluckman,et al.  Glucose tolerance in adults after prenatal exposure to famine , 2001, The Lancet.

[7]  M. West-Eberhard.  Phenotypic Plasticity and the Origins of Diversity , 1989 .

[8]  E. Widdowson,et al.  Cellular Development of Some Human Organs Before Birth , 1972, Archives of disease in childhood.

[9]  M Marmot,et al.  Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort , 1994, The Lancet.

[10]  J. Eriksson,et al.  Trajectories of growth among children who have coronary events as adults. , 2005, The New England journal of medicine.

[11]  D J Barker,et al.  Fetal origins of coronary heart disease , 1995, BMJ.

[12]  P. McKeigue,et al.  Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15 000 Swedish men and women born 1915-29 , 1998, BMJ.

[13]  C. A. Newsome,et al.  Is birth weight related to later glucose and insulin metabolism?—a systematic review , 2003, Diabetic medicine : a journal of the British Diabetic Association.

[14]  R. Mccance.  Food, growth, and time. , 1962, Lancet.

[15]  J. Eriksson,et al.  Self-Perpetuating Effects of Birth Size on Blood Pressure Levels in Elderly People , 2003, Hypertension.

[16]  M. Rutter,et al.  Design for a Life: How Behaviour Develops. By P. Bateson & P. Martin. Jonathan Cape, London. pp. 280. £16.99 (hb). , 2001 .

[17]  Bernard Rosner,et al.  Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976 , 1997, BMJ.

[18]  J. Eriksson,et al.  Fetal origins of adult disease: strength of effects and biological basis. , 2002, International journal of epidemiology.

[19]  R. Hanson,et al.  Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? , 1994, BMJ.

[20]  C Osmond,et al.  Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations. , 2000, Hypertension.

[21]  J. Meulen.  Glucose tolerance in adults after prenatal exposure to famine , 2001, The Lancet.

[22]  Clive Osmond,et al.  The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth. , 2002, Diabetes.

[23]  T P Fleming,et al.  Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. , 2000, Development.

[24]  H. Syddall,et al.  Birth weight and the risk of depressive disorder in late life , 2001, British Journal of Psychiatry.

[25]  D. Phillips,et al.  Insulin resistance as a programmed response to fetal undernutrition , 1996, Diabetologia.

[26]  R. Huxley,et al.  The role of size at birth and postnatal catch‐up growth in determining systolic blood pressure: a systematic review of the literature , 2000, Journal of hypertension.

[27]  M. Marmot,et al.  Psychosocial and material pathways in the relation between income and health: a response to Lynch et al , 2001, BMJ : British Medical Journal.

[28]  W. Dietz,et al.  Overweight in childhood and adolescence. , 2004, The New England journal of medicine.

[29]  J. Eriksson,et al.  Extreme hypertrophic cardiomyopathy , 2003, Heart.

[30]  R. Huxley,et al.  Unravelling the fetal origins hypothesis , 2002, The Lancet.

[31]  J. Ingelfinger,et al.  Is microanatomy destiny? , 2003, The New England journal of medicine.

[32]  C Osmond,et al.  Size at birth and resilience to effects of poor living conditions in adult life: longitudinal study , 2001, BMJ : British Medical Journal.

[33]  R. Mccance,et al.  The effect of finite periods of undernutrition at different ages on the composition and subsequent development of the rat , 1963, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[34]  D. Barker,et al.  WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE , 1989, The Lancet.

[35]  C Osmond,et al.  Early growth and death from cardiovascular disease in women. , 1993, BMJ.

[36]  C Osmond,et al.  Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study , 1999, BMJ.

[37]  C Osmond,et al.  Fetal growth and coronary heart disease in South India , 1996, The Lancet.

[38]  A. Harris,et al.  Carboplatin/cisplatin , 2012, Reactions Weekly.

[39]  P. Elwood,et al.  Birthweight, body-mass index in middle age, and incident coronary heart disease , 1996, The Lancet.

[40]  E. Mellanby.  Nutrition and child-bearing. , 1933 .

[41]  J. Harding,et al.  The nutritional basis of the fetal origins of adult disease. , 2001, International journal of epidemiology.

[42]  P. McKeigue,et al.  Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years , 1996, BMJ.

[43]  Clive Osmond,et al.  The Fetal and Childhood Growth of Persons Who Develop Type 2 Diabetes , 2000, Annals of Internal Medicine.

[44]  B. Brenner,et al.  Congenital oligonephropathy: an inborn cause of adult hypertension and progressive renal injury? , 1993, Current opinion in nephrology and hypertension.

[45]  D. Barker.  Fetal origins of coronary heart disease , 1995, BMJ.

[46]  Clive Osmond,et al.  Growth and living conditions in childhood and hypertension in adult life: a longitudinal study , 2002, Journal of hypertension.

[47]  H. Abdalla,et al.  Birth weight: nature or nurture? , 1995, Early human development.

[48]  J. Manson,et al.  Birthweight and the Risk for Type 2 Diabetes Mellitus in Adult Women , 1999, Annals of Internal Medicine.

[49]  T. Forsén,et al.  Unravelling the fetal origins hypothesis , 2002, The Lancet.

[50]  C Osmond,et al.  Fetal and infant growth and impaired glucose tolerance at age 64. , 1991, BMJ.

[51]  A. Lucas,et al.  Early origins of cardiovascular disease: is there a unifying hypothesis? , 2004, The Lancet.