, Sheila Population-Based Prospective Study European Prospective Investigation Into Cancer and Nutrition in Norfolk Cohort : A Body Fat Distribution and Risk of Coronary Heart Disease in Men and Women in the

Dexter Canoy, S. Matthijs Boekholdt, Nicholas Wareham, Robert Luben, Ailsa Welch, Sheila Population-Based Prospective Study European Prospective Investigation Into Cancer and Nutrition in Norfolk Cohort : A Body Fat Distribution and Risk of Coronary Heart Disease in Men and Women in the Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2007 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.106.673756 2007;116:2933-2943; originally published online December 10, 2007; Circulation. http://circ.ahajournals.org/content/116/25/2933 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://circ.ahajournals.org/content/suppl/2008/01/10/CIRCULATIONAHA.106.673756.DC1.html Data Supplement (unedited) at:

[1]  N. Day,et al.  Serum lipid concentration in relation to anthropometric indices of central and peripheral fat distribution in 20,021 British men and women: results from the EPIC-Norfolk population-based cohort study. , 2006, Atherosclerosis.

[2]  Walter C Willett,et al.  Obesity as Compared With Physical Activity in Predicting Risk of Coronary Heart Disease in Women , 2006, Circulation.

[3]  Mark Woodward,et al.  Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies , 2005, BMJ : British Medical Journal.

[4]  S. Yusuf,et al.  Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case-control study , 2005, The Lancet.

[5]  P. Soubrié,et al.  The CB1 receptor antagonist rimonabant reverses the diet‐induced obesity phenotype through the regulation of lipolysis and energy balance , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  N. Day,et al.  Cigarette smoking and fat distribution in 21,828 British men and women: a population-based study. , 2005, Obesity research.

[7]  N. Day,et al.  Fat distribution, body mass index and blood pressure in 22 090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study , 2004, Journal of hypertension.

[8]  P. J. Larsen,et al.  Novel Associations Between Bioavailable Estradiol and Adipokines in Elderly Women With Different Phenotypes of Obesity: Implications for Atherogenesis , 2004, Circulation.

[9]  R. Peters,et al.  Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study. , 2004, The American journal of medicine.

[10]  Andrew R Coggan,et al.  Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. , 2004, The New England journal of medicine.

[11]  William E Kraus,et al.  Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE--a randomized controlled study. , 2004, Archives of internal medicine.

[12]  Lauren Lissner,et al.  Hip circumference and cardiovascular morbidity and mortality in men and women. , 2004, Obesity research.

[13]  T. Welborn,et al.  Waist–hip ratio is the dominant risk factor predicting cardiovascular death in Australia , 2003, The Medical journal of Australia.

[14]  P. J. Larsen,et al.  Central and peripheral fat mass have contrasting effect on the progression of aortic calcification in postmenopausal women. , 2003, European heart journal.

[15]  Giel Nijpels,et al.  Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study. , 2003, The American journal of clinical nutrition.

[16]  Claus Christiansen,et al.  Peripheral Adiposity Exhibits an Independent Dominant Antiatherogenic Effect in Elderly Women , 2003, Circulation.

[17]  M. Visser,et al.  Larger thigh and hip circumferences are associated with better glucose tolerance: the Hoorn study. , 2003, Obesity research.

[18]  K. Frayn,et al.  Adipose tissue as a buffer for daily lipid flux , 2002, Diabetologia.

[19]  T. Lakka,et al.  Abdominal obesity is associated with increased risk of acute coronary events in men. , 2002, European heart journal.

[20]  F. Lönnqvist,et al.  A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding , 2002, International Journal of Obesity.

[21]  N. Day,et al.  Validity and repeatability of the EPIC-Norfolk Physical Activity Questionnaire. , 2002, International journal of epidemiology.

[22]  C. Björkelund,et al.  Larger hip circumference independently predicts health and longevity in a Swedish female cohort. , 2001, Obesity research.

[23]  L. Pérusse,et al.  Waist and hip circumferences have independent and opposite effects on cardiovascular disease risk factors: the Quebec Family Study. , 2001, The American journal of clinical nutrition.

[24]  J. Buring,et al.  Abdominal and total adiposity and risk of coronary heart disease in men , 2001, International Journal of Obesity.

[25]  A. Astrup,et al.  Obesity : Preventing and managing the global epidemic , 2000 .

[26]  B. Nicklas,et al.  Dietary restriction and walking reduce fat deposition in the midthigh in obese older women. , 2000, The American journal of clinical nutrition.

[27]  T. Sellers,et al.  Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study. , 2000, Archives of internal medicine.

[28]  A. Hamsten,et al.  Regional Variation in Plasminogen Activator Inhibitor-1 Expression in Adipose Tissue from Obese Individuals , 2000, Thrombosis and Haemostasis.

[29]  G. Shulman,et al.  Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. , 2000, The Journal of clinical investigation.

[30]  P. Wahl,et al.  Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study. , 1999, Diabetes care.

[31]  Judith D. Goldberg,et al.  Applied Survival Analysis , 1999, Technometrics.

[32]  N. Day,et al.  EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. , 1999, British journal of cancer.

[33]  A. Folsom,et al.  Body Mass Index, Waist/Hip Ratio, and Coronary Heart Disease Incidence in African Americans and Whites , 1998 .

[34]  G A Colditz,et al.  Abdominal adiposity and coronary heart disease in women. , 1998, JAMA.

[35]  J V Hajnal,et al.  Magnetic resonance imaging of total body fat. , 1998, Journal of applied physiology.

[36]  D. Hosmer,et al.  A Simplified Method of Calculating an Overall Goodness-of-Fit Test for the Cox Proportional Hazards Model , 1998, Lifetime data analysis.

[37]  E. Feskens,et al.  Narrow hips and broad waist circumferences independently contribute to increased risk of non‐insulin‐dependent diabetes mellitus , 1997, Journal of internal medicine.

[38]  H. Kahn,et al.  Contrasting factors associated with abdominal and peripheral weight gain among adult women , 1997, International Journal of Obesity.

[39]  P. B. Jensen,et al.  Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans. , 1996, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[40]  P. Björntorp.  The regulation of adipose tissue distribution in humans. , 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[41]  J. Seidell,et al.  Waist circumference action levels in the identification of cardiovascular risk factors: prevalence study in a random sample , 1995, BMJ.

[42]  D Spiegelman,et al.  Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men. , 1995, American journal of epidemiology.

[43]  D. Jacobs,et al.  Changes in measurements of body fat distribution accompanying weight change. , 1994, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[44]  C. Bouchard,et al.  Genetic and nongenetic determinants of regional fat distribution. , 1993, Endocrine reviews.

[45]  P. Rust,et al.  Body mass index and body girths as predictors of mortality in black and white men. , 1992, American journal of epidemiology.

[46]  W. Haskell,et al.  Waist/hip ratio, body mass index and premature cardiovascular disease mortality in US Army veterans during a twenty-three year follow-up study. , 1992, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[47]  A Tremblay,et al.  Estimation of deep abdominal adipose-tissue accumulation from simple anthropometric measurements in men. , 1991, The American journal of clinical nutrition.

[48]  G. Miller,et al.  Alcohol consumption: protection against coronary heart disease and risks to health. , 1990, International journal of epidemiology.

[49]  P. Björntorp.  "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. , 1990, Arteriosclerosis.

[50]  W. Kannel,et al.  Hazards of obesity--the Framingham experience. , 2009, Acta medica Scandinavica. Supplementum.

[51]  K. Pennert,et al.  Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. , 1984, British medical journal.

[52]  P. Björntorp,et al.  Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. , 1984, British medical journal.