Speeding Disease Gene Discovery with SUSPECTS

SUSPECTS is a web based tool designed to help researchers prioritize genes in a region of interest. It is based on the assumption that the genes underlying a particular complex disease tend to share the same or similar biological pathways. The Gene Ontology annotation, Interpro domains, expression profiles and sequence features of each gene in the region are compared with a training set of genes already implicated in the disease. Genes are automatically assigned a score on the basis of the number of different lines of evidence where a match was found and the significance of those matches; this score reflects the relative probability of the gene's involvement in the disease under study.