Activation of human macrophages. Comparison of other cytokines with interferon-gamma

Cytokines affecting mononuclear phagocytes were screened for activation of human macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon-gamma (rIFN gamma), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon- alpha (nIFN alpha), rIFN alpha A, rIFN alpha D, rIFN beta, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study.

[1]  Mark S. Anderson,et al.  Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance , 2014, The Journal of experimental medicine.

[2]  H. Winkler,et al.  Cloned mouse interferon-gamma inhibits the growth of Rickettsia prowazekii in cultured mouse fibroblasts , 1983, The Journal of experimental medicine.

[3]  H. Murray,et al.  Gamma-interferon is the factor in lymphokine that activates human macrophages to inhibit intracellular Chlamydia psittaci replication. , 1983, Journal of immunology.

[4]  H. Murray,et al.  Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine. , 1983, The Journal of clinical investigation.

[5]  L. Old,et al.  Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[6]  C. Nathan,et al.  Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity , 1983, The Journal of experimental medicine.

[7]  T. Taniguchi,et al.  Structure and expression of a cloned cDNA for human interleukin-2 , 1983, Nature.

[8]  D. Rosenstreich,et al.  Interferon-induced enhancement of macrophage Fc receptor expression: beta-interferon treatment of C3H/HeJ macrophages results in increased numbers and density of Fc receptors. , 1983, Journal of immunology.

[9]  S. Pestka,et al.  Specific molecular activities of recombinant and hybrid leukocyte interferons. , 1982, The Journal of biological chemistry.

[10]  A. Waheed,et al.  Effect of colony stimulating factor on murine macrophages. Induction of antitumor activity. , 1982, The Journal of clinical investigation.

[11]  P. Tynan,et al.  Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy , 1982, Cell.

[12]  L. Forman,et al.  Human colony-stimulating factor (CSF-1) radioimmunoassay: resolution of three subclasses of human colony-stimulating factors. , 1981, Blood.

[13]  P. McCarthy,et al.  Purification of guinea pig pH 3 migration inhibitory factor. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Jett,et al.  Augmentation of human monocyte-mediated cytolysis by interferon. , 1980, Cellular immunology.

[15]  D. Burke,et al.  A monoclonal antibody for large-scale purification of human leukocyte interferon , 1980, Nature.

[16]  A. Burgess,et al.  Stimulation of macrophage plasminogen activator activity by colony‐stimulating factors , 1980, Journal of cellular physiology.

[17]  P. Ralph,et al.  Induction of prostaglandin E synthesis in normal and neoplastic macrophages: role for colony-stimulating factor(s) distinct from effects on myeloid progenitor cell proliferation. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[18]  A. Burgess,et al.  Stimulation by granulocyte-macrophage colony-stimulating factor of Leishmania tropica killing by macrophages. , 1979, Journal of immunology.

[19]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[20]  C. Nathan,et al.  Mechanisms of macrophage antimicrobial activity. , 1983, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[21]  R. Schultz.  Synergistic activation of macrophages by lymphokine and lipopolysaccharide: evidence for lymphokine as the primer and interferon as the trigger. , 1982, Journal of interferon research.