The aggressiveness of urothelial carcinoma depends to a large extent on lymphovascular invasion – the prognostic contribution of related molecular markers

Aims:  Bladder cancer is the second most common malignancy of the urogenital region. The majority of bladder cancer deaths occur as a consequence of metastatic disease. Blood vessel density (BVD), a surrogate marker for angiogenesis, has been shown to be predictive of progression and poor prognosis, as well as lymphatic vessel density (LVD). The aim of this study was to evaluate, in human urothelial bladder cancer (UBC), the clinical and prognostic significance of angiogenesis, lymphangiogenesis and lymphovascular invasion, assessed with the use of specific immunohistochemical markers.

[1]  S. Sonnad,et al.  The presence of lymphovascular invasion in radical cystectomy specimens from patients with urothelial carcinoma portends a poor clinical prognosis , 2008, BJU international.

[2]  R. Muschel,et al.  Immunohistochemical Method Identifies Lymphovascular Invasion in a Majority of Oral Squamous Cell Carcinomas and Discriminates between Blood and Lymphatic Vessel Invasion , 2008, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[3]  K. Kihara,et al.  Lymphovascular invasion is independently associated with poor prognosis in patients with localized upper urinary tract urothelial carcinoma treated surgically. , 2008, The Journal of urology.

[4]  P. Alken,et al.  Prognostic implications of lymphangiogenesis in muscle-invasive transitional cell carcinoma of the bladder. , 2008, European urology.

[5]  C. Dinney,et al.  Growth factors and receptors as prognostic markers in urothelial carcinoma , 2008, Current urology reports.

[6]  F. Schmitt,et al.  How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis? , 2007, World journal of surgical oncology.

[7]  M. Neeman,et al.  Lymphatic vessel density and function in experimental bladder cancer , 2007, BMC Cancer.

[8]  L. Hertle,et al.  VEGF-C, VEGF-D and Flt-4 in transitional bladder cancer: relationships to clinicopathological parameters and long-term survival. , 2007, Anticancer research.

[9]  C. Dinney,et al.  Bladder cancer angiogenesis and metastasis—translation from murine model to clinical trial , 2007, Cancer and Metastasis Reviews.

[10]  G. Molenberghs,et al.  Occurrence of both bladder and prostate cancer in five cancer registries in Belgium, The Netherlands and the United Kingdom. , 2007, European journal of cancer.

[11]  T. Habuchi,et al.  Lymphatic invasion is a prognostic factor for bladder cancer treated with radical cystectomy , 2007, International Journal of Clinical Oncology.

[12]  S. Fox,et al.  First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours , 2006, British Journal of Cancer.

[13]  X. Zu,et al.  Vascular endothelial growth factor‐C expression in bladder transitional cell cancer and its relationship to lymph node metastasis , 2006, BJU international.

[14]  F. Algaba.  Lymphovascular invasion as a prognostic tool for advanced bladder cancer , 2006, Current opinion in urology.

[15]  I. Giannopoulou,et al.  Evaluation of the vascular endothelial growth factor (VEGF)-C role in urothelial carcinomas of the bladder. , 2006, Anticancer research.

[16]  N. Masumori,et al.  Removal of more lymph nodes may provide better outcome, as well as more accurate pathologic findings, in patients with bladder cancer--analysis of role of pelvic lymph node dissection. , 2006, Urology.

[17]  Y. Lotan,et al.  Lymphovascular invasion is independently associated with overall survival, cause-specific survival, and local and distant recurrence in patients with negative lymph nodes at radical cystectomy. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  K. Ohba,et al.  Lymphangiogenesis and Angiogenesis in Bladder Cancer: Prognostic Implications and Regulation by Vascular Endothelial Growth Factors-A, -C, and -D , 2006, Clinical Cancer Research.

[19]  M. Rizzo,et al.  Qualitative and quantitative analysis of angiogenetic factors in transitional cell bladder carcinoma: relationship with clinical course at 10 years follow-up. , 2005, Oncology reports.

[20]  K. Harada,et al.  Prognostic significance of vascular invasion in patients with bladder cancer who underwent radical cystectomy , 2005, International journal of urology.

[21]  Kazumi Suzuki,et al.  Vascular endothelial growth factor‐C (VEGF‐C) expression predicts lymph node metastasis of transitional cell carcinoma of the bladder , 2005, International journal of urology : official journal of the Japanese Urological Association.

[22]  K. O'Byrne,et al.  Microvessel density at presentation predicts subsequent muscle invasion in superficial bladder cancer. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[23]  L. Lacombe,et al.  Can biological markers predict recurrence and progression of superficial bladder cancer? , 2000, Current opinion in urology.

[24]  J. Folkman,et al.  Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. , 1991, The New England journal of medicine.

[25]  H. Miyake,et al.  Risk factors for intravesical recurrence after surgical management of transitional cell carcinoma of the upper urinary tract. , 2008, Urology.

[26]  R. Ji.  Lymphatic endothelial cells, tumor lymphangiogenesis and metastasis: New insights into intratumoral and peritumoral lymphatics , 2006, Cancer and Metastasis Reviews.

[27]  Ö. Tulunay,et al.  Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis , 2004, International Urology and Nephrology.

[28]  C. Compton,et al.  AJCC Cancer Staging Manual , 2002, Springer New York.