Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.
暂无分享,去创建一个
Zoe Cournia | William L Jorgensen | Lin Leng | W. L. Jorgensen | L. Leng | R. Bucala | Z. Cournia | Richard Bucala | Sunilkumar Gandavadi | Xin Du | Xin Du | Sunilkumar Gandavadi
[1] William L Jorgensen,et al. Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. , 2006, Bioorganic & medicinal chemistry letters.
[2] J. Bernhagen,et al. Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[3] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .
[4] J. Bernhagen,et al. Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF). , 1994, Biochemistry.
[5] S. Yamamoto,et al. Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. , 2001, Journal of medicinal chemistry.
[6] E. Morand,et al. Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor. , 2004, The Journal of rheumatology.
[7] M. Orita,et al. Macrophage migration inhibitory factor and the discovery of tautomerase inhibitors. , 2002, Current pharmaceutical design.
[8] Peter Björk,et al. The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase , 1997, FEBS letters.
[9] S. Todo,et al. An antibody for macrophage migration inhibitory factor suppresses tumour growth and inhibits tumour-associated angiogenesis. , 2000, Cytokine.
[10] Tina Peng,et al. Sustained Mitogen-activated Protein Kinase (MAPK) and Cytoplasmic Phospholipase A2 Activation by Macrophage Migration Inhibitory Factor (MIF) , 1999, The Journal of Biological Chemistry.
[11] A. Chait,et al. Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages. , 1997, Arteriosclerosis, thrombosis, and vascular biology.
[12] M. González-Gay,et al. Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus , 2006, Genes and Immunity.
[13] J. Bernhagen,et al. MIF as a glucocorticoid-induced modulator of cytokine production , 1995, Nature.
[14] K. Iczkowski,et al. Inhibition of Macrophage Migration Inhibitory Factor or Its Receptor (CD74) Attenuates Growth and Invasion of DU-145 Prostate Cancer Cells1 , 2006, The Journal of Immunology.
[15] R. Bucala,et al. Macrophage migration inhibitory factor , 2003, Critical care medicine.
[16] T. Hagemann,et al. Ovarian cancer cell–derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis , 2007, Molecular Cancer Therapeutics.
[17] Y. Al-Abed,et al. Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity. , 2006, Bioorganic & medicinal chemistry letters.
[18] E Lolis,et al. Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity. , 1999, Biochemistry.
[19] Matthew P. Repasky,et al. Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. , 2006, Journal of medicinal chemistry.
[20] J. Bernhagen,et al. MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis , 2006, Nature Reviews Drug Discovery.
[21] Elias Lolis,et al. The Tautomerase Active Site of Macrophage Migration Inhibitory Factor Is a Potential Target for Discovery of Novel Anti-inflammatory Agents* , 2002, The Journal of Biological Chemistry.
[22] C. P. Whitman,et al. Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants. , 2000, Biochemistry.
[23] John David,et al. Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[24] R. Bucala,et al. An Essential Role for Macrophage Migration Inhibitory Factor (MIF) in Angiogenesis and the Growth of a Murine Lymphoma , 1999, Molecular medicine.
[25] R. Bucala,et al. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity by dopachrome analogs. , 1999, Bioorganic & medicinal chemistry letters.
[26] L. Leng,et al. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. , 2006, Immunity.
[27] L. Leng,et al. MIF Signal Transduction Initiated by Binding to CD74 , 2003, The Journal of experimental medicine.
[28] R. Bucala,et al. Biochemical and mutational investigations of the enzymatic activity of macrophage migration inhibitory factor. , 1997, Biochemistry.
[29] R. Bucala,et al. The Immunoregulatory Mediator Macrophage Migration Inhibitory Factor (MIF) Catalyzes a Tautomerization Reaction , 1996, Molecular medicine.
[30] M. Swope,et al. Macrophage migration inhibitory factor: cytokine, hormone, or enzyme? , 1999, Reviews of physiology, biochemistry and pharmacology.
[31] Annette Lee,et al. Macrophage migration inhibitory factor (MIF) gene polymorphisms are associated with increased prostate cancer incidence , 2007, Genes and Immunity.
[32] W. L. Jorgensen,et al. Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids , 1996 .
[33] R. Bucala,et al. Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity. , 2002, Journal of medicinal chemistry.
[34] Matthew P. Repasky,et al. Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. , 2004, Journal of medicinal chemistry.
[35] Michael Bacher,et al. ISO-1 Binding to the Tautomerase Active Site of MIF Inhibits Its Pro-inflammatory Activity and Increases Survival in Severe Sepsis* , 2005, Journal of Biological Chemistry.
[36] J. Proudfoot,et al. The evolution of synthetic oral drug properties. , 2005, Bioorganic & medicinal chemistry letters.
[37] M. Fitzgerald,et al. Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor. , 1998, Biochemistry.
[38] W. Johnson,et al. Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition. , 1999, Biochemistry.
[39] Peter D. Senter,et al. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[40] Brian K. Shoichet,et al. ZINC - A Free Database of Commercially Available Compounds for Virtual Screening , 2005, J. Chem. Inf. Model..
[41] R. Bucala,et al. Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant-induced arthritis. , 2000, Arthritis and rheumatism.
[42] R. Bucala,et al. Macrophage migration inhibitory factor: a critical component of autoimmune inflammatory diseases. , 2005, Drug news & perspectives.