The vomeronasal organ – incidence in a Bulgarian population

Abstract Background: The vomeronasal organ is an accessory olfactory organ found in vertebrates that specialises in the chemoreception of pheromones. This study aimed to explore the existence and occurrence of the vomeronasal organ in adult humans. Methods: A total of 966 consecutive video recordings of out-patient nasopharyngolaryngoscopies performed at the St Marina University Hospital, Varna, Bulgaria, were retrospectively reviewed. Results: Data analysis showed that from the evaluable cases, the organ was evident on the left side of the nasal septum in 14.93 per cent, on the right side in 21.15 per cent and bilaterally in 2.35 per cent of cases. The vomeronasal organ was present in a total of 26.83 per cent of the investigated subjects. Conclusion: More research should be focused on revealing the incidence and functionality of the organ, and on its preservation in surgical manipulations that affect the nasal septum and other nearby structures.

[1]  P. Hoogland,et al.  Anatomical evidence for an endocrine activity of the vomeronasal organ in humans , 2014, Clinical anatomy.

[2]  A. Issa Nervi Terminalis, Vomeronasalis and Olfactorius of Uromastyx aegyptius (Squamata – Lacertilia - Agamidae) , 2012 .

[3]  R. W. Gilmer,et al.  The Terminal Nerve : A New Chemosensory System in Vertebrates ? , 2011 .

[4]  P. Lennon,et al.  Ectopic olfactory neuroblastoma: report of four cases and a review of the literature , 2011, European Archives of Oto-Rhino-Laryngology.

[5]  Nikolay Sapundzhiev,et al.  DIGITAL ONCOLOGY PATIENT RECORD - HETEROGENEOUS FILE BASED APPROACH , 2010 .

[6]  R. Foltán,et al.  Behavioral changes of patients after orthognathic surgery develop on the basis of the loss of vomeronasal organ: a hypothesis , 2009, Head & face medicine.

[7]  N. Sarycheva,et al.  Characteristics of exploratory behavior and the level of uneasiness of white nonpurebred rats after extirpation of the vomeronasal organ (VNO) , 2007, Doklady Biological Sciences.

[8]  M. Witt,et al.  Structure and function of the vomeronasal organ. , 2006, Advances in oto-rhino-laryngology.

[9]  C. Wysocki,et al.  Facts, fallacies, fears, and frustrations with human pheromones. , 2004, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

[10]  K. Hüttenbrink,et al.  Das vomeronasale Organ des Menschen , 2003, Der Nervenarzt.

[11]  K. P. Bhatnagar,et al.  The human vomeronasal organ. V. An interpretation of its discovery by Ruysch, Jacobson, or Kölliker, with an English translation of Kölliker (1877). , 2003, Anatomical record. Part B, New anatomist.

[12]  T. Hummel,et al.  [The human vomeronasal organ]. , 2003, Der Nervenarzt.

[13]  K. P. Bhatnagar,et al.  The Human Vomeronasal Organ: Part IV. Incidence, Topography, Endoscopy, and Ultrastructure of the Nasopalatine Recess, Nasopalatine Fossa, and Vomeronasal Organ , 2002, American journal of rhinology.

[14]  K. P. Bhatnagar,et al.  Histological definition of the vomeronasal organ in humans and chimpanzees, with a comparison to other primates , 2002, The Anatomical record.

[15]  K. P. Bhatnagar,et al.  Anatomical position of the vomeronasal organ in postnatal humans. , 2001, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[16]  M. Meredith,et al.  Human vomeronasal organ function: a critical review of best and worst cases. , 2001, Chemical senses.

[17]  T. Hummel,et al.  Imaging of the human vomeronasal duct. , 2001, Chemical senses.

[18]  K. P. Bhatnagar,et al.  The human vomeronasal organ. Part II: prenatal development , 2000, Journal of anatomy.

[19]  K. Døving,et al.  The vomeronasal cavity in adult humans. , 2000, Chemical senses.

[20]  R. Conran,et al.  The Vomeronasal Organ: An Objective Anatomic Analysis of its Prevalence , 2000, Ear, nose, & throat journal.

[21]  E. Keverne,et al.  The vomeronasal organ. , 1999, Science.

[22]  R. Axel,et al.  Expression of candidate pheromone receptor genes in vomeronasal neurons. , 1998, Chemical senses.

[23]  A. Burdi,et al.  Searching for the vomeronasal organ of adult humans: Preliminary findings on location, structure, and size , 1998, Microscopy research and technique.

[24]  H. Gaafar,et al.  The vomeronasal (Jacobson's) organ in adult humans: frequency of occurrence and enzymatic study. , 1998, Acta oto-laryngologica.

[25]  D. Berliner,et al.  The functionality of the human vomeronasal organ (VNO): Evidence for steroid receptors , 1996, The Journal of Steroid Biochemistry and Molecular Biology.

[26]  C. Wysocki,et al.  Behavioral responses of male guinea pigs to conspecific chemical signals following neonatal vomeronasal organ removal , 1987, Physiology & Behavior.

[27]  M. Lehman,et al.  Luteinizing Hormone‐Releasing Hormone in the Vomeronasal System and Terminal Nerve of the Hamster a , 1987, Annals of the New York Academy of Sciences.

[28]  M. Hawke,et al.  Clinical and histological evidence for the presence of the vomeronasal (Jacobson's) organ in adult humans. , 1985, The Journal of otolaryngology.

[29]  L. S. Demski The Evolution of Neuroanatomical Substrates of Reproductive Behavior: Sex Steroid and LHRH-Specific Pathways Including the Terminal Nerve , 1984 .

[30]  B. Jafek,et al.  The Vomeronasal Organ of Jacobson in the Human Embryo and Fetus , 1980, Otolaryngology and head and neck surgery.

[31]  R. Estes THE ROLE OF THE VOMERONASAL ORGAN IN MAMMALIAN REPRODUCTION , 1972 .

[32]  J. Kratzing The structure of the vomeronasal organ in the sheep. , 1971, Journal of anatomy.