Mouse "reduced in osteosclerosis" transporter (Roct) functions as an organic anion transporter 3 (mOAT3) and is localized at abluminal membrane of blood-brain barrier

Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences (S.O., T.K., S.M., S.H., H.T. and T.T.), and New Industry Creation Hatchery Center (S.O., S.H., H.T. and T.T.), Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. SORST of Japan Science and Technology Agency (JST), Japan (S.O., S.H., H.T. and T.T.). Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan (M.O.) JPET Fast Forward. Published on February 4, 2004 as DOI:10.1124/jpet.103.063370

[1]  P. A. Friedman,et al.  Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport. , 2003, American journal of physiology. Renal physiology.

[2]  T. Takano,et al.  Signaling at the Gliovascular Interface , 2003, The Journal of Neuroscience.

[3]  J. Kim,et al.  Identification of a Novel Voltage-driven Organic Anion Transporter Present at Apical Membrane of Renal Proximal Tubule* , 2003, Journal of Biological Chemistry.

[4]  Yuichi Sugiyama,et al.  Contribution of Organic Anion Transporters to the Renal Uptake of Anionic Compounds and Nucleoside Derivatives in Rat , 2003, Journal of Pharmacology and Experimental Therapeutics.

[5]  A. Enomoto,et al.  Interactions of human organic anion as well as cation transporters with indoxyl sulfate. , 2003, European journal of pharmacology.

[6]  H. Takanaga,et al.  Rat Organic Anion Transporter 3 (rOAT3) is Responsible for Brain-to-Blood Efflux of Homovanillic Acid at the Abluminal Membrane of Brain Capillary Endothelial Cells , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  Xiao‐ping Yang,et al.  Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. , 2003, American journal of physiology. Renal physiology.

[8]  H. Fukushima,et al.  Calcitonin inhibits proton extrusion in resorbing rat osteoclasts via protein kinase A , 2003, Pflügers Archiv.

[9]  H. Takanaga,et al.  Role of blood–brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain , 2002, Journal of neurochemistry.

[10]  D. Beier,et al.  Impaired Organic Anion Transport in Kidney and Choroid Plexus of Organic Anion Transporter 3 (Oat3 (Slc22a8)) Knockout Mice* , 2002, The Journal of Biological Chemistry.

[11]  H. Kusuhara,et al.  Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. , 2002, Molecular pharmacology.

[12]  N. Takahashi,et al.  Regulatory mechanisms of osteoblast and osteoclast differentiation. , 2002, Oral diseases.

[13]  R. Takayanagi,et al.  Dehydroepiandrosterone (DHEA) as a possible source for estrogen formation in bone cells: correlation between bone mineral density and serum DHEA-sulfate concentration in postmenopausal women, and the presence of aromatase to be enhanced by 1,25-dihydroxyvitamin D3 in human osteoblasts , 2002, Mechanisms of Ageing and Development.

[14]  H. Kusuhara,et al.  Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. , 2002, The Journal of pharmacology and experimental therapeutics.

[15]  Steve D. M. Brown,et al.  A radiation hybrid map of mouse genes , 2001, Nature Genetics.

[16]  A. Villa,et al.  The mutational spectrum of human malignant autosomal recessive osteopetrosis. , 2001, Human molecular genetics.

[17]  T. Abe,et al.  Characterization of the Efflux Transport of 17β-Estradiol-d-17β-glucuronide from the Brain across the Blood-Brain Barrier , 2001 .

[18]  Y. Kanai,et al.  Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. , 2001, Molecular pharmacology.

[19]  O. Jaillon,et al.  The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants. , 2000, Bone.

[20]  J. Kim,et al.  Molecular Cloning and Characterization of Multispecific Organic Anion Transporter 4 Expressed in the Placenta* , 2000, The Journal of Biological Chemistry.

[21]  H. Kusuhara,et al.  Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain* , 1999, The Journal of Biological Chemistry.

[22]  K. P. Brady,et al.  A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. , 1999, Genomics.

[23]  V. Sheffield,et al.  Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation. , 1998, Human molecular genetics.

[24]  J. Tytgat,et al.  Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs , 1992, Neuron.

[25]  A. L. Goldin.  Maintenance of Xenopus laevis and oocyte injection. , 1992, Methods in enzymology.

[26]  T Nakagawa,et al.  A pharmacokinetic analysis program (multi) for microcomputer. , 1981, Journal of pharmacobio-dynamics.