Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis

[1]  B. Illek,et al.  Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[2]  K. Chai,et al.  Regulation of prostasin expression and function in the prostate , 2004, The Prostate.

[3]  James P. Quigley,et al.  Membrane anchored serine proteases: A rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer , 2003, Cancer and Metastasis Reviews.

[4]  P. Wolters,et al.  Structure and Activity of Human Pancreasin, a Novel Tryptic Serine Peptidase Expressed Primarily by the Pancreas* , 2003, The Journal of Biological Chemistry.

[5]  E. Maher,et al.  Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumours , 2003, Oncogene.

[6]  D. Berney,et al.  Testis conserving chemotherapy in germ cell cancer: its potential to increase understanding of the biology and treatment of carcinoma‐in‐situ , 2003, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[7]  R. Lothe,et al.  The testicular germ cell tumour genome , 2003, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[8]  R. Lothe,et al.  Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer , 2002, Oncogene.

[9]  Z. Gatalica,et al.  Loss of Fhit Expression in Testicular Germ Cell Tumors and Intratubular Germ Cell Neoplasia , 2002, Modern Pathology.

[10]  M. Esteller CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future , 2002, Oncogene.

[11]  J. Christman,et al.  5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy , 2002, Oncogene.

[12]  T. Baba,et al.  A Mouse Serine Protease TESP5 Is Selectively Included into Lipid Rafts of Sperm Membrane Presumably as a Glycosylphosphatidylinositol-anchored Protein* , 2002, The Journal of Biological Chemistry.

[13]  K. Chai,et al.  Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation , 2002, International journal of cancer.

[14]  M. Toyota,et al.  Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer , 2002, International journal of cancer.

[15]  S. Sukumar,et al.  CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression. , 2001, Cancer research.

[16]  T. Tsuji,et al.  The E‐cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas , 2001, International journal of cancer.

[17]  D. Nicol,et al.  An orthotopic xenograft model of human nonseminomatous germ cell tumour , 2001, British Journal of Cancer.

[18]  N. Greenberg,et al.  Down‐regulation of prostasin serine protease: A potential invasion suppressor in prostate cancer , 2001, The Prostate.

[19]  K. Jung,et al.  Expression of the normal epithelial cell-specific 1 (NES1; KLK10) candidate tumour suppressor gene in normal and malignant testicular tissue , 2001, British Journal of Cancer.

[20]  A. Renshaw,et al.  Transition from In Situ to Invasive Testicular Germ Cell Neoplasia is Associated with the Loss of p21 and Gain of mdm-2 Expression , 2001, Modern Pathology.

[21]  K. Shigemasa,et al.  Overexpression of Testisin, a Serine Protease Expressed by Testicular Germ Cells, in Expithelial Ovarian Tumor Cells , 2000, The Journal of the Society for Gynecologic Investigation: JSGI.

[22]  R. Hoffman,et al.  2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia. , 2000, Blood.

[23]  S. Wen,et al.  Clues to the aetiological heterogeneity of testicular seminomas and non-seminomas: time trends and age-period-cohort effects. , 2000, International journal of epidemiology.

[24]  J. Bartek,et al.  Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis , 2000, Oncogene.

[25]  D. Kastner,et al.  Localization, expression and genomic structure of the gene encoding the human serine protease testisin. , 2000, Biochimica et biophysica acta.

[26]  S. Clark,et al.  Hypermethylation of E-cadherin in leukemia. , 2000, Blood.

[27]  N. Farman,et al.  Activation of the amiloride-sensitive epithelial sodium channel by the serine protease mCAP1 expressed in a mouse cortical collecting duct cell line. , 2000, Journal of the American Society of Nephrology : JASN.

[28]  M. Isobe,et al.  Structural analysis of esp-1 gene (PRSS 21). , 1999, Biochemical and biophysical research communications.

[29]  Thierry Boon,et al.  DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter , 1999, Molecular and Cellular Biology.

[30]  J. Herman,et al.  Hypermethylation of tumor suppressor genes in cancer. , 1999, Seminars in cancer biology.

[31]  S. Lutzker,et al.  Testicular germ cell tumors: molecular understanding and clinical implications. , 1998, Molecular medicine today.

[32]  J. Dickinson,et al.  Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors. , 1999, Cancer research.

[33]  L. Looijenga,et al.  Pathogenesis of testicular germ cell tumours. , 1999, Reviews of reproduction.

[34]  M. Kurosawa,et al.  Cloning and tissue distribution of a novel serine protease esp-1 from human eosinophils. , 1998, Biochemical and biophysical research communications.

[35]  D. Wazer,et al.  The role for NES1 serine protease as a novel tumor suppressor. , 1998, Cancer research.

[36]  L. E. McDonald,et al.  Distinct Methylation of the Interferon γ (IFN-γ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-γ Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells , 1998, The Journal of experimental medicine.

[37]  J. Moul,et al.  MOLECULAR ANALYSIS OF P16Ink4/CDKN2 AND P15Ink4B/MTS2 GENES IN PRIMARY HUMAN TESTICULAR GERM CELL TUMORS , 1998 .

[38]  S. Clark,et al.  Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA. , 1997, Nucleic acids research.

[39]  J. Flint,et al.  The relationship between chromosome structure and function at a human telomeric region , 1997, Nature Genetics.

[40]  L. E. McDonald,et al.  Methylation analysis using bisulfite genomic sequencing: application to small numbers of intact cells. , 1997, BioTechniques.

[41]  A. Olek,et al.  A modified and improved method for bisulphite based cytosine methylation analysis. , 1996, Nucleic acids research.

[42]  A. Sandberg,et al.  Reviews of chromosome studies in urological tumors. III. Cytogenetics and genes in testicular tumors. , 1996, The Journal of urology.

[43]  P. Boyle,et al.  Continuing increase in incidence of germ‐cell testis cancer in young adults: Experience from Connecticut, USA, 1935–1992 , 1996, International journal of cancer.

[44]  D. Ward,et al.  Structure and chromosomal localization of the human prostasin (PRSS8) gene. , 1996, Genomics.

[45]  Lee Chao,et al.  Molecular Cloning, Tissue-specific Expression, and Cellular Localization of Human Prostasin mRNA (*) , 1995, The Journal of Biological Chemistry.

[46]  S. Clark,et al.  High sensitivity mapping of methylated cytosines. , 1994, Nucleic acids research.

[47]  L. Chao,et al.  Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland. , 1994, The Journal of biological chemistry.

[48]  A. Bird,et al.  Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl‐CpG binding protein. , 1992, The EMBO journal.

[49]  S. Hauser,et al.  A simple method for DNA purification from peripheral blood. , 1988, Analytical biochemistry.

[50]  M. Frommer,et al.  CpG islands in vertebrate genomes. , 1987, Journal of molecular biology.

[51]  P. Stern,et al.  Cloned human teratoma cells differentiate into neuron-like cells and other cell types in retinoic acid. , 1984, Journal of cell science.

[52]  R. Harris,et al.  Genetics of Human Cancer , 1977, British Journal of Cancer.

[53]  J. Fogh,et al.  Absence of HeLa cell contamination in 169 cell lines derived from human tumors. , 1977, Journal of the National Cancer Institute.

[54]  T. Chen,et al.  In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. , 1977, Experimental cell research.

[55]  K. Pienta,et al.  Testicular Cancer , 2009, Nature Reviews Disease Primers.

[56]  P. Vasey,et al.  New directions in testicular cancer; molecular determinants of oncogenesis and treatment success. , 2003, European journal of cancer.

[57]  Ahmedin Jemal,et al.  Cancer Statistics, 2002 , 2002, CA: a cancer journal for clinicians.

[58]  J. Herman,et al.  Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer , 1999, Nature Genetics.

[59]  J. Moul,et al.  Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. , 1998, The Journal of urology.

[60]  J. Herman,et al.  Alterations in DNA methylation: a fundamental aspect of neoplasia. , 1998, Advances in cancer research.

[61]  A. Bird,et al.  Effects of DNA methylation on DNA-binding proteins and gene expression. , 1993, Current opinion in genetics & development.

[62]  S. Baylin,et al.  Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression. , 1991, Cancer cells.