Phaeohyphomycosis due to Exophiala infections in solid organ transplant recipients: Case report and literature review

This case report and literature review underscores the cutaneous presentations of phaeohyphomycosis in the solid organ transplant population. Increased cognizance with prompt identification is critical. The therapy and clinical outcomes of phaeohyphomycosis, caused by the Exophiala genus, in the solid organ transplant population, is analyzed to examine optimal care. This review highlights the inherent difficulties in providing the appropriate duration of antifungal therapy to avoid relapsing infections in immunosuppressed patients.

[1]  K. Bi,et al.  Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice , 2017, Xenobiotica; the fate of foreign compounds in biological systems.

[2]  S. H. Alves,et al.  Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates , 2016, The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.

[3]  J. Tomimori,et al.  Spectral Manifestation of Melanized Fungal Infections in Kidney Transplant Recipients: Report of Six Cases , 2016, Mycopathologia.

[4]  K. Mukherjee,et al.  Brain abscess due to Cladophialophora bantiana: a review of 124 cases. , 2016, Medical mycology.

[5]  Baojian Wu,et al.  Metabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1 , 2016, Xenobiotica; the fate of foreign compounds in biological systems.

[6]  I. Xess,et al.  “A fine needle aspiration cytology in time saves nine” — cutaneous phaeohyphomycosis caused by Exophiala jeanselmei in a renal transplant patient: Diagnosis by fine needle aspiration cytology , 2016, Journal of cytology.

[7]  C. Festa Neto,et al.  Phaeohyphomycosis in renal transplantation: report of two cases* , 2016, Anais brasileiros de dermatologia.

[8]  A. Mandal,et al.  Phaeohyphomycosis Due to Exophiala jeanselmei: An Emerging Pathogen in India—Case Report and Review , 2016, Mycopathologia.

[9]  R. Aarnoutse,et al.  Drug-interactions of azole antifungals with selected immunosuppressants in transplant patients: strategies for optimal management in clinical practice. , 2015, Current opinion in pharmacology.

[10]  S. Nair,et al.  Phaeohyphomycosis presenting as a solitary nodulocystic lesion in a renal transplant patient , 2015, Indian dermatology online journal.

[11]  M. Binitha,et al.  Disseminated cutaneous phaeohyphomycosis due to Cladophialophora bantiana. , 2015, Indian journal of dermatology, venereology and leprology.

[12]  P. Le Pape,et al.  Multifocal phaeohyphomycosis caused by Exophiala xenobiotica in a kidney transplant recipient , 2015, Transplant infectious disease : an official journal of the Transplantation Society.

[13]  H. Yokoyama,et al.  Case of cutaneous phaeohyphomycosis caused by Phaeoacremonium sp. in a renal transplant recipient , 2015, Journal of dermatology (Print).

[14]  Chia-Chi Hsu,et al.  Cutaneous alternariosis in a renal transplant recipient: a case report and literature review. , 2015, Asian journal of surgery.

[15]  D. Sutton,et al.  A case of Exophiala oligosperma successfully treated with voriconazole , 2013, Medical mycology case reports.

[16]  H. Tanabe,et al.  Case of phaeohyphomycosis producing sporotrichoid lesions , 2013, Journal of dermatology (Print).

[17]  K. Makimura,et al.  A case of phaeohyphomycosis caused by Exophiala oligosperma successfully treated with local hyperthermia. , 2013, Medical mycology journal.

[18]  A. Chakrabarti,et al.  Exophiala dermatitidis endocarditis on native aortic valve in a postrenal transplant patient and review of literature on E. dermatitidis infections , 2013, Mycoses.

[19]  E. Bottone,et al.  Exophiala jeanselmei infection in solid organ transplant recipients: report of two cases and review of the literature , 2011, Transplant infectious disease : an official journal of the Transplantation Society.

[20]  R. Galimberti,et al.  Lymphocutaneous nocardiosis and cutaneous pheohyphomycosis in a liver transplant recipient , 2008, International journal of dermatology.

[21]  J. Val-Bernal,et al.  Subcutaneous phaeohyphomycosis caused by Exophiala oligosperma in a renal transplant recipient , 2007, The British journal of dermatology.

[22]  Ana Arribi-Vilela,et al.  [Subcutaneous lesion in a renal transplant recipient]. , 2006, Enfermedades infecciosas y microbiologia clinica.

[23]  Maria R R Silva,et al.  Subcutaneoous phaeohyphomycosis by Exophiala jeanselmei in a cardiac transplant recipient. , 2005, Revista do Instituto de Medicina Tropical de Sao Paulo.

[24]  D. Andes,et al.  Exophiala jeanselmei infection in a heart transplant recipient successfully treated with oral terbinafine. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[25]  K. Chung,et al.  Nephrogenic fibrosing dermopathy: response to high‐dose intravenous immunoglobulin , 2004, The British journal of dermatology.

[26]  S. Euvrard,et al.  Two cases of subcutaneous phaeohyphomycosis due to Exophiala jeanselmei, in cardiac transplant and renal transplant patients , 2004, The British journal of dermatology.

[27]  P. Hsueh,et al.  Phaeohyphomycosis caused by Exophiala species in immunocompromised hosts. , 2002, Journal of the Formosan Medical Association = Taiwan yi zhi.

[28]  G. Procop,et al.  Relapsing Exophiala jeanselmei phaeohyphomycosis in a lung‐transplant patient , 2001, Transplant infectious disease : an official journal of the Transplantation Society.

[29]  H. Palevsky,et al.  Subcutaneous Phaeohyphomycotic Cysts Caused by Exophiala jeanselmei in a Lung Transplant Patient , 2001, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[30]  J. Henao,et al.  Phaeohyphomycosis in kidney transplant patients , 1999, Clinical transplantation.

[31]  E. E. Sahn,et al.  Subcutaneous phaeohyphomycosis and nocardiosis in a kidney transplant patient. , 1997, Journal of the American Academy of Dermatology.

[32]  W. Gold,et al.  Successful treatment of systemic and local infections due to Exophiala species. , 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[33]  W. Farrar,et al.  Phaeohyphomycosis due to Exophiala species: clinical spectrum of disease in humans. , 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[34]  M. Mcginnis,et al.  Human infection caused by Exophiala pisciphila: case report and review. , 1991, Reviews of infectious diseases.

[35]  Y. Sasai,et al.  Cutaneous Phaeohyphomycosis Caused by Exophiala jeanselmei After Renal Transplantation , 1990, International journal of dermatology.

[36]  R. Hudson,et al.  Exophiala jeanselmei infection in a postrenal transplant patient. , 1985, Journal of the American Academy of Dermatology.

[37]  R. D. de Zeeuw,et al.  Intra- and inter-species comparisons of biliary metabolic profiles of butoprozine by high performance liquid chromatography. , 1985, Xenobiotica; the fate of foreign compounds in biological systems.