Impact of new water systems on healthcare-associated colonization or infection with Pseudomonas aeruginosa

Aim: We aimed to study the impact of new water systems, which were less contaminated with P. aeruginosa, on the incidence of healthcare-associated P. aeruginosa cases (colonizations or infections) in care units that moved to a different building between 2005 and 2014. Methods: Generalized Estimated Equations were used to compare the incidence of P. aeruginosa healthcare-associated cases according to the building. Results: Twenty-nine units moved during the study period and 2,759 cases occurred in these units. No difference was observed when the new building was compared with older buildings overall. Conclusion: Our results did not support our hypothesis of a positive association between water system contamination and the incidence of healthcare-associated P. aeruginosa cases. These results must be confirmed by linking results of water samples and patients’ data.

[1]  T. Palmore,et al.  Waterborne Pathogen Detection More than Just “Location, Location, Location…” , 2014, Infection Control & Hospital Epidemiology.

[2]  A. Kramer,et al.  GMS Hygiene and Infection Control , 2013, GMS hygiene and infection control.

[3]  H. Stryhn,et al.  A simulation study to assess statistical methods for binary repeated measures data. , 2010, Preventive veterinary medicine.

[4]  B. Cournoyer,et al.  Spatio‐temporal analysis of infra‐specific genetic variations among a Pseudomonas aeruginosa water network hospital population: invasion and selection of clonal complexes , 2008, Journal of applied microbiology.

[5]  J. Cui.  QIC: Stata module to compute model selection criterion in GEE analyses , 2008 .

[6]  Michael C. Wendl,et al.  Argonaute—a database for gene regulation by mammalian microRNAs , 2005, BMC Bioinformatics.

[7]  M. Haller,et al.  Ecology of Pseudomonas aeruginosa in the intensive care unit and the evolving role of water outlets as a reservoir of the organism. , 2005, American journal of infection control.

[8]  S. Engelhart,et al.  Prevention and control of health care-associated waterborne infections in health care facilities. , 2005, American journal of infection control.

[9]  J. Newbold,et al.  Effects of Current Velocity on the Nascent Architecture of Stream Microbial Biofilms , 2003, Applied and Environmental Microbiology.

[10]  Lynne Sehulster,et al.  Guidelines for environmental infection control in health-care facilities. Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC). , 2003, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[11]  S. Saby,et al.  Biofilms in Drinking Water Distribution Systems , 2003 .

[12]  E. Anaissie,et al.  The hospital water supply as a source of nosocomial infections: a plea for action. , 2002, Archives of internal medicine.

[13]  C. F. von Reyn,et al.  Nosocomial infections due to nontuberculous mycobacteria. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[14]  F B Hu,et al.  Comparison of population-averaged and subject-specific approaches for analyzing repeated binary outcomes. , 1998, American journal of epidemiology.

[15]  K. Kerr,et al.  Association between healthcare water systems and Pseudomonas aeruginosa infections: a rapid systematic review. , 2014, The Journal of hospital infection.