Aging of the human crystalline lens and anterior segment

Changes in the unaccommodated human crystalline lens were characterized as a function of subject age for 100 normal emmetropes over the age range 18-70 yr by Scheimpflug slit-lamp photography. With increasing age, the lens becomes thicker sagittally, but since the distance from the cornea to the posterior lens surface remains unchanged, this indicates that the center of lens mass moves anteriorly and the anterior chamber becomes shallower. Sagittal nuclear thickness is independent of age, but both anterior and posterior cortical thicknesses increase with age, shifting the location of the nucleus and the central sulcus in the anterior direction. The amount of light scattered by the lens at high angles, as represented by normalized and integrated lens densities from the digitized images, increases with increasing age in an exponential fashion. Similar relationships to age are observed for the major anterior zone of discontinuity (maximum density) and the central sulcus (minimum density). The relationships of these results to accommodation and presbyopia are discussed.

[1]  A. Bron,et al.  Changes in light scatter and width measurements from the human lens cortex with age , 1992, Eye.

[2]  G. Shun-Shin,et al.  Light scatter from the central human cornea , 1990, Eye.

[3]  Johannes W. Rohen,et al.  Age-related changes of the human ciliary muscle. A quantitative morphometric study , 1992, Mechanisms of Ageing and Development.

[4]  Jane F. Koretz,et al.  Acquisition of the curves of the human crystalline lens from slit lamp images: an application of the Hough transform. , 1991, Applied optics.

[5]  Jane F. Koretz,et al.  Accommodation and presbyopia in the human eye—aging of the anterior segment , 1989, Vision Research.

[6]  P. Farnsworth,et al.  Anterior zonular shifts with age. , 1979, Experimental Eye Research.

[7]  N. Brown,et al.  The change in lens curvature with age. , 1974, Experimental eye research.

[8]  G. Bresnick,et al.  Lenses of diabetic patients "yellow" at an accelerated rate similar to older normals. , 1991, Investigative ophthalmology & visual science.

[9]  N. Brown,et al.  The change in shape and internal form of the lens of the eye on accommodation. , 1973, Experimental eye research.

[10]  Jane F. Koretz,et al.  Analysis of human crystalline lens curvature as a function of accommodative state and age , 1984, Vision Research.

[11]  R. Fisher.  The elastic constants of the human lens , 1971, The Journal of physiology.

[12]  J. Greve,et al.  Raman microspectroscopy of fixed rabbit and human lenses and lens slices: new potentialities. , 1989, Experimental eye research.

[13]  G F Vrensen,et al.  Age-related changes in local water and protein content of human eye lenses measured by Raman microspectroscopy. , 1991, Experimental eye research.

[14]  N. Brown.  An advanced slit-image camera. , 1972, The British journal of ophthalmology.

[15]  A Duane,et al.  Studies in Monocular and Binocular Accommodation, with Their Clinical Application. , 1922, Transactions of the American Ophthalmological Society.

[16]  R. Fisher.  Elastic constants of the human lens capsule , 1969, The Journal of physiology.

[17]  J F Koretz,et al.  How the human eye focuses. , 1988, Scientific American.

[18]  J. Koretz,et al.  Accommodation and presbyopia in the human eye. 1: Evaluation of in vivo measurement techniques. , 1989, Applied optics.

[19]  J. Greve,et al.  Local variation in absolute water content of human and rabbit eye lenses measured by Raman microspectroscopy. , 1989, Experimental eye research.

[20]  M. Lou,et al.  Protein-thiol mixed disulfides in human lens. , 1992, Experimental eye research.